Commentary
Journal of Investigative Dermatology (2007) 127, 744–745. doi:10.1038/sj.jid.5700693
Soluble Fas Ligand: Is It a Critical Mediator of Toxic Epidermal Necrolysis and Stevens–Johnson Syndrome?
Junko Murata1 and Riichiro Abe1
1Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Correspondence: Dr. Riichiro Abe, Department of Dermatology, Hokkaido University Graduate School of Medicine, N 15 W 7, Kita-ku, Sapporo 060-8638, Japan. E-mail: aberi@med.hokudai.ac.jp
Abstract
Although soluble Fas ligand (sFasL) is an important candidate in toxic epidermal necrolysis (TEN) and Stevens–Johnson syndrome (SJS), Stur and colleagues report that elevated sFasL has been detected in maculopapular rashes. In addition to sFasL, other factors, including predisposing genetic factors, should also be investigated to determine their precise pathogenesis in TEN and SJS.
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