TABLE OF CONTENTS

Volume 127, Issue 3 (March 2007)

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Editorials

The Nature of Clinical Evidence: Floating Currencies Rather than Gold Standards FREE

Associate Editor Jonathan Rees

J Invest Dermatol 127: 499-500; doi:10.1038/sj.jid.5700730

Research Snippets FREE

J Invest Dermatol 127: 502; doi:10.1038/sj.jid.5700780

Editors' Picks FREE

J Invest Dermatol 127: 503; doi:10.1038/sj.jid.5700762

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Commentaries

Fleshing Out Filaggrin Phenotypes FREE

Alan D Irvine

J Invest Dermatol 127: 504-507; doi:10.1038/sj.jid.5700695

See also: Original Article by Barker et al. See also: Letter to the Editor by Stemmler et al. See also: Letter to the Editor by Weidinger et al.

Pseudoxanthoma Elasticum-Like Phenotypes: More Diseases than One FREE

Jouni Uitto and Qiujie Jiang

J Invest Dermatol 127: 507-510; doi:10.1038/sj.jid.5700635

See also: Original Article by Vanakker et al.

Expanding the Roles of Antimicrobial Peptides in Skin: Alarming and Arming Keratinocytes FREE

Jürgen Schauber and Richard L Gallo

J Invest Dermatol 127: 510-512; doi:10.1038/sj.jid.5700761

See also: Original Article by Niyonsaba et al.

Complicated Hyaluronan Patterns in Skin: Enlightenment by UVB? FREE

Robert Stern

J Invest Dermatol 127: 512-513; doi:10.1038/sj.jid.5700605

See also: Original Article by Averbeck et al.
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Perspectives

Wound Healing

Inflammation in Wound Repair: Molecular and Cellular Mechanisms FREE

Sabine A Eming, Thomas Krieg and Jeffrey M Davidson

J Invest Dermatol 127: 514-525; doi:10.1038/sj.jid.5700701

Formation and Function of the Myofibroblast during Tissue Repair FREE

Boris Hinz

J Invest Dermatol 127: 526-537; doi:10.1038/sj.jid.5700613

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Original Articles

Wound Healing

Regulation of NF-kappaB Activity and Keratinocyte Differentiation by the RIP4 Protein: Implications for Cutaneous Wound Repair FREE

Stephanie Adams, Sandra Pankow, Sabine Werner and Barbara Munz

J Invest Dermatol 127: 538-544; advance online publication, October 12, 2006; doi:10.1038/sj.jid.5700588

Cell Biology

Lack of Nidogen-1 and -2 Prevents Basement Membrane Assembly in Skin-Organotypic Coculture FREE

Roswitha Nischt, Cathrine Schmidt, Nicolae Mirancea, Anke Baranowsky, Sharada Mokkapati, Neil Smyth, Eva C Woenne, Hans-Jürgen Stark, Petra Boukamp and Dirk Breitkreutz

J Invest Dermatol 127: 545-554; advance online publication, September 28, 2006; doi:10.1038/sj.jid.5700562

Colocalization of Glial Fibrillary Acidic Protein, Metallothionein, and MHC II in Human, Rat, NOD/SCID, and Nude Mouse Skin Keratinocytes and Fibroblasts FREE

Lusine Danielyan, Genrich Tolstonog, Peter Traub, Juergen Salvetter, Christoph H Gleiter, Dieter Reisig, Rolf Gebhardt and Gayane H Buniatian

J Invest Dermatol 127: 555-563; advance online publication, September 28, 2006; doi:10.1038/sj.jid.5700575

Genetics

Null Mutations in the Filaggrin Gene (FLG) Determine Major Susceptibility to Early-Onset Atopic Dermatitis that Persists into Adulthood FREE

Jonathan N W N Barker, Colin N A Palmer, Yiwei Zhao, Haihui Liao, Peter R Hull, Simon P Lee, Michael H Allen, Simon J Meggitt, Nicholas J Reynolds, Richard C Trembath and W H Irwin McLean

J Invest Dermatol 127: 564-567; advance online publication, September 21, 2006; doi:10.1038/sj.jid.5700587

See also: Commentary by Irvine
DNA-Based Prenatal Diagnosis of Harlequin Ichthyosis and Characterization of ABCA12 Mutation Consequences FREE

Masashi Akiyama, Matthias Titeux, Kaori Sakai, James R McMillan, Laure Tonasso, Patrick Calvas, Frederique Jossic, Alain Hovnanian and Hiroshi Shimizu

J Invest Dermatol 127: 568-573; advance online publication, November 2, 2006; doi:10.1038/sj.jid.5700617

Epidermolysis Bullosa Simplex in Scotland Caused by a Spectrum of Keratin Mutations FREE

Elizabeth L Rugg, Helen M Horn, Frances J Smith, Neil J Wilson, Alison J M Hill, Gareth J Magee, Carrie S Shemanko, David U Baty, Michael J Tidman and E Birgitte Lane

J Invest Dermatol 127: 574-580; advance online publication, October 12, 2006; doi:10.1038/sj.jid.5700571

Pseudoxanthoma Elasticum-Like Phenotype with Cutis Laxa and Multiple Coagulation Factor Deficiency Represents a Separate Genetic Entity FREE

Olivier M Vanakker, Ludovic Martin, Dealba Gheduzzi, Bart P Leroy, Bart L Loeys, Veronica I Guerci, Dirk Matthys, Sharon F Terry, Paul J Coucke, Ivonne Pasquali-Ronchetti and Anne De Paepe

J Invest Dermatol 127: 581-587; advance online publication, November 16, 2006; doi:10.1038/sj.jid.5700610

See also: Commentary by Uitto & Jiang
Novel Mutations in the BHD Gene and Absence of Loss of Heterozygosity in Fibrofolliculomas of Birt-Hogg-Dubé Patients FREE

Maurice A M van Steensel, Valerie L R M Verstraeten, Jorge Frank, Nicole W J Kelleners-Smeets, Pamela Poblete-Gutiérrez, Dominique Marcus-Soekarman, Reno S Bladergroen, Peter M Steijlen and Michel van Geel

J Invest Dermatol 127: 588-593; advance online publication, November 23, 2006; doi:10.1038/sj.jid.5700592

Immunology/Infection

Antimicrobial Peptides Human beta-Defensins Stimulate Epidermal Keratinocyte Migration, Proliferation and Production of Proinflammatory Cytokines and Chemokines FREE

François Niyonsaba, Hiroko Ushio, Nobuhiro Nakano, William Ng, Koji Sayama, Koji Hashimoto, Isao Nagaoka, Ko Okumura and Hideoki Ogawa

J Invest Dermatol 127: 594-604; advance online publication, October 19, 2006; doi:10.1038/sj.jid.5700599

See also: Commentary by Schauber & Gallo
Intermedin: A Skin Peptide that Is Downregulated in Atopic Dermatitis FREE

Friederike Kindt, Silke Wiegand, Christoph Löser, Martin Nilles, Volker Niemeier, Sheau Yu Teddy Hsu, Martin Steinhoff, Wolfgang Kummer, Uwe Gieler and Rainer Viktor Haberberger

J Invest Dermatol 127: 605-613; advance online publication, September 28, 2006; doi:10.1038/sj.jid.5700576

Cyclooxygenase-2 Inhibition Promotes Enhancement of Antitumor Responses by Transcutaneous Vaccination with Cytosine-Phosphate-Guanosine-Oligodeoxynucleotides and Model Tumor Antigen FREE

Joe Inoue and Yukihiko Aramaki

J Invest Dermatol 127: 614-621; advance online publication, December 7, 2006; doi:10.1038/sj.jid.5700656

Tissue Homing and Persistence of Defined Antigen-Specific CD8+ Tumor-Reactive T-Cell Clones in Long-Term Melanoma Survivors FREE

Frédérique-Anne Le Gal, Valérie M Widmer, Valérie Dutoit, Verena Rubio-Godoy, Jacques Schrenzel, Paul R Walker, Pedro J Romero, Danila Valmori, Daniel E Speiser and Pierre-Yves Dietrich

J Invest Dermatol 127: 622-629; advance online publication, October 12, 2006; doi:10.1038/sj.jid.5700580

Investigation of Mechanisms Underlying the T-Cell Response to the Hapten 2,4-Dinitrochlorobenzene FREE

Chris Pickard, Andrew M Smith, Hywel Cooper, Ian Strickland, John Jackson, Eugene Healy and Peter S Friedmann

J Invest Dermatol 127: 630-637; advance online publication, September 28, 2006; doi:10.1038/sj.jid.5700581

Local Activation of the Innate Immune System in Buruli Ulcer Lesions FREE

Elisabetta Peduzzi, Célia Groeper, Daniela Schütte, Paul Zajac, Simona Rondini, Ernestina Mensah-Quainoo, Giulio Cesare Spagnoli, Gerd Pluschke and Claudia Andrea Daubenberger

J Invest Dermatol 127: 638-645; advance online publication, October 19, 2006; doi:10.1038/sj.jid.5700593

Keratinocytes/Epidermis

Electrophilic Chemicals but not UV Irradiation or Reactive Oxygen Species Activate Nrf2 in Keratinocytes In Vitro and In Vivo  FREE

Moritz Durchdewald, Tobias A Beyer, Delinda A Johnson, Jeffrey A Johnson, Sabine Werner and Ulrich auf dem Keller

J Invest Dermatol 127: 646-653; advance online publication, September 28, 2006; doi:10.1038/sj.jid.5700585

Effects of Skin Surface Temperature on Epidermal Permeability Barrier Homeostasis FREE

Mitsuhiro Denda, Takaaki Sokabe, Tomoko Fukumi-Tominaga and Makoto Tominaga

J Invest Dermatol 127: 654-659; advance online publication, October 19, 2006; doi:10.1038/sj.jid.5700590

Stimulation of Purinergic Receptors Modulates Chemokine Expression in Human Keratinocytes FREE

Saveria Pastore, Francesca Mascia, Sara Gulinelli, Sylvia Forchap, Cristina Dattilo, Elena Adinolfi, Giampiero Girolomoni, Francesco Di Virgilio and Davide Ferrari

J Invest Dermatol 127: 660-667; advance online publication, October 12, 2006; doi:10.1038/sj.jid.5700591

Melanocytes/Melanoma

Lysophosphatidylcholine Mediates Melanocyte Dendricity through PKCzeta Activation FREE

Glynis A Scott, Manubu Arioka and Stacey E Jacobs

J Invest Dermatol 127: 668-675; advance online publication, October 5, 2006; doi:10.1038/sj.jid.5700567

Piebald Trait: Implication of kit Mutation on In Vitro Melanocyte Survival and on the Clinical Application of Cultured Epidermal Autografts FREE

Sergio Bondanza, Melissa Bellini, Gaia Roversi, Desanka Raskovic, Riccardo Maurelli, Emanuel Paionni, Patrizia Paterna, Elena Dellambra, Lidia Larizza and Liliana Guerra

J Invest Dermatol 127: 676-686; advance online publication, November 23, 2006; doi:10.1038/sj.jid.5700639

Photobiology

Differential Regulation of Hyaluronan Metabolism in the Epidermal and Dermal Compartments of Human Skin by UVB Irradiation FREE

Marco Averbeck, Carl A Gebhardt, Susanne Voigt, Simone Beilharz, Ulf Anderegg, Christian C Termeer, Jonathan P Sleeman and Jan C Simon

J Invest Dermatol 127: 687-697; advance online publication, November 2, 2006; doi:10.1038/sj.jid.5700614

See also: Commentary by Stern
Regulation of UVB-Induced IL-8 and MCP-1 Production in Skin Keratinocytes by Increasing Vitamin C Uptake via the Redistribution of SVCT-1 from the Cytosol to the Membrane FREE

Jae Seung Kang, Ha Na Kim, Da Jung Jung, Jee Eun Kim, Ga Hee Mun, Yeong Seok Kim, Daeho Cho, Dong Hoon Shin, Young-Il Hwang and Wang Jae Lee

J Invest Dermatol 127: 698-706; advance online publication, September 28, 2006; doi:10.1038/sj.jid.5700572

Photoprotection by 1,25 Dihydroxyvitamin D3 Is Associated with an Increase in p53 and a Decrease in Nitric Oxide Products FREE

Ritu Gupta, Katie M Dixon, Shivashni S Deo, Carolyn J Holliday, Michael Slater, Gary M Halliday, Vivienne E Reeve and Rebecca S Mason

J Invest Dermatol 127: 707-715; advance online publication, December 14, 2006; doi:10.1038/sj.jid.5700597

Vascular Biology

Galanin-Like Peptides Exert Potent Vasoactive Functions In Vivo  FREE

Sabine M Schmidhuber, Radmila Santic, Christina W Tam, Johann W Bauer, Barbara Kofler and Susan D Brain

J Invest Dermatol 127: 716-721; advance online publication, October 5, 2006; doi:10.1038/sj.jid.5700569

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Letters to the Editor

Two Common Loss-of-Function Mutations within the Filaggrin Gene Predispose for Early Onset of Atopic Dermatitis FREE

Susanne Stemmler, Qumar Parwez, Elisabeth Petrasch-Parwez, Joerg T Epplen and Sabine Hoffjan

J Invest Dermatol 127: 722-724; advance online publication, September 28, 2006; doi:10.1038/sj.jid.5700579

See also: Commentary by Irvine

Filaggrin Mutations Strongly Predispose to Early-Onset and Extrinsic Atopic Dermatitis FREE

Stephan Weidinger, Elke Rodríguez, Caroline Stahl, Stefan Wagenpfeil, Norman Klopp, Thomas Illig and Natalija Novak

J Invest Dermatol 127: 724-726; advance online publication, November 9, 2006; doi:10.1038/sj.jid.5700630

See also: Commentary by Irvine

Differences in Imiquimod Treatment Outcome in Two Patients with Bowenoid Papulosis Containing Either Episomal or Integrated Human Papillomavirus 16 FREE

Georges P H Lucker, Ernst-Jan M Speel, David H K Creytens, Adrienne J van Geest, Jolanda H M Peeters, Sandra M H Claessen, Anton H M Vermeulen, Patrick Pauwels and Els V Meulemans

J Invest Dermatol 127: 727-729; advance online publication, September 28, 2006; doi:10.1038/sj.jid.5700578

CRH Mediates Inflammation Induced by Lipopolysaccharide in Human Adult Epidermal Keratinocytes FREE

Blazej Zbytek and Andrzej T Slominski

J Invest Dermatol 127: 730-732; advance online publication, October 19, 2006; doi:10.1038/sj.jid.5700607

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Erratum

Effects of Skin Surface Temperature on Epidermal Permeability Barrier Homeostasis FREE

J Invest Dermatol 127: 733; advance online publication, January 11, 2007; doi:10.1038/sj.jid.5700678

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