TABLE 2
FROM:
Filaggrin Mutations Strongly Predispose to Early-Onset and Extrinsic Atopic Dermatitis
Stephan Weidinger, Elke Rodríguez, Caroline Stahl, Stefan Wagenpfeil, Norman Klopp, Thomas Illig and Natalija Novak
BACK TO ARTICLETable 2. Results of the logistic regression models adjusted for age and sex using backward variable selection
| R501X | 2282del4 | Combined genotype Aa | |||||||
|---|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | P-value | OR | 95% CI | P-value | OR | 95% CI | P-value | |
| AD | 3.51 | (1.39; 8.84) | 0.0079 | 4.98 | (2.37; 10.48) | 2.3  10-5
| 3.53 | (1.92; 6.48) | 4.9 10-5
|
| Extrinsic AD | 4.02 | (1.58; 10.26) | 0.0035 | 5.00 | (2.34; 10.69) | 3.3 10-6
| 3.66 | (1.96; 6.83) | 4.6 10-5
|
| AD+asthma | 5.07 | (1.73; 14.81) | 0.0030 | 7.49 | (3.18; 17.63) | 4.0 10-6
| 5.69 | (2.76; 11.73) | 2.5 10-6
|
| AD+rhinitis | 4.10 | (1.55; 10.87) | 0.0045 | 5.83 | (2.68; 12.68) | 8.9 10-6
| 4.04 | (2.11; 7.72) | 2.4 10-5
|
| Total IgE | NS | 3.29 | (1.56; 6.97) | 0.0018 | 2.14 | (1.14; 4.00) | 0.0178 | ||
| Early-onset AD | 5.66 | (2.05; 15.62) | 0.0008 | 7.18 | (3.17; 16.25) | 2.3 10-6
| 5.21 | (2.61; 10.40) | 2.8 10-6
|
| SCORAD (objective components, median >31) | NS | 3.16 | (1.49; 6.72) | 0.0027 | 2.65 | (1.36; 5.17) | 0.0043 | ||
Abbreviations: AD, atopic dermatitis; CI, confidence interval; NS, nonsignificant; OR, odds ratio.