Journal of Investigative Dermatology - Figure 1 for article: Oxidative Stress Via Hydrogen Peroxide Affects Proopiomelanocortin Peptides Directly in the Epidermis of Patients with Vitiligo

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Oxidative Stress Via Hydrogen Peroxide Affects Proopiomelanocortin Peptides Directly in the Epidermis of Patients with Vitiligo

Jennifer D Spencer, Nicholas C J Gibbons, Hartmut Rokos, Eva M J Peters, John M Wood and Karin U Schallreuter

Figure 1.

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In situ expression of POMC peptides in healthy controls and in patients with vitiligo. Epidermal expression of the POMC peptides (a–d) -MSH and (e–h) -endorphin, (i–l) -MSH, and (m–p) ACTH, is decreased in active patients with vitiligo compared to healthy controls. After reduction/removal of epidermal H₂O₂ by a narrowband UVB-activated pseudocatalase PC-KUS, the peptides recover (a, e, i, m) healthy control, (b, f, j, n) untreated skin, (c, g, k, o) treated repigmenting skin, (d, h, l, p) antibody neutralization with blocking peptide, and (q–t) image analysis of staining intensities. Bar=100 M. Note the strong expression of -endorphin in basal melanocytes (e, g).

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FIGURE 1

Oxidative Stress Via Hydrogen Peroxide Affects Proopiomelanocortin Peptides Directly in the Epidermis of Patients with Vitiligo

Figure 1.