TABLE 4
FROM:
Induction of Inflammatory Cytokines by a Keratin Mutation and their Repression by a Small Molecule in a Mouse Model for EBS
Hong Lu, Jian Chen, Laura Planko, Paola Zigrino, Ludger Klein-Hitpass and Thomas M Magin
BACK TO ARTICLETable 4. Differentially expressed genes in the microarray profiling in K5-/- epidermis following doxycycline treatment
| Fold | |
|---|---|
| Genes downregulated | |
| Bcl2-like 10 | 0.40 |
| MMP-13 | 0.37 |
| IFN-activated gene 202B | 0.37 |
Phosphatidylinositol-4-phosphate 5-kinase, type 1
| 0.36 |
| Regulator of G-protein signaling 7 | 0.34 |
IL-1
| 0.28 |
| IFN-activated gene 202B | 0.24 |
| Insulin receptor | 0.23 |
| Distal-less homeobox 6 | 0.22 |
| Chemokine (C–C motif) ligand 1 | 0.21 |
| Paired box gene 6 | 0.20 |
| S100 calcium binding protein A (calgranulin A) | 0.13 |
| Protease, serine 12 neurontrypsin (motopsin) | 0.11 |
| Genes upregulated | |
| Procollagen type III 1 | 39.95 |
| Insulin-like growth factor binding protein 1 | 32.9 |
| Procollagen type I 1 | 18.38 |
| Procollagen type VI 3 | 15.03 |
| Fibrinogen gammapolypeptide | 11.79 |
| Leptin receptor | 11.31 |
| Serine (or cysteine) proteinase inhibitor, clade F, member 1 | 6.41 |
| Procollagen type I 2 | 5.74 |
| Twist gene homolog 1 (Drosophila) | 4.50 |
| Procollagen type V 2 | 3.29 |
| Delta-like 1 homolog (Drosophila) | 2.93 |
| Procollagen type I 1 | 2.60 |
