Commentary
Journal of Investigative Dermatology (2007) 127, 8–10. doi:10.1038/sj.jid.5700609
Breach Delivery: Increased Solute Uptake Points to a Defective Skin Barrier in Atopic Dermatitis
W H Irwin McLean1 and Peter R Hull1
1Epithelial Genetics Group, Human Genetics Unit, Division of Pathology and Neuroscience, University of Dundee, Ninewells Hospital and Medical School, Dundee, United Kingdom
Correspondence: Prof. W.H. Irwin McLean, Human Genetics Unit, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom. E-mail w.h.i.mclean@dundee.ac.uk
Abstract
Evidence is now emerging for enhanced penetration of chemical solutes into uninvolved skin of atopic dermatitis patients. Along with the recent discovery of prevalent null mutations in the gene encoding filaggrin, a protein essential for stratum corneum formation, these data point to an innate epidermal-barrier defect in atopy.
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