Commentary
Journal of Investigative Dermatology (2006) 126, 1931–1932. doi:10.1038/sj.jid.5700457
Non-pathogenic Anti-Desmoglein 3 IgG Autoantibodies in Fogo Selvagem
Masayuki Amagai1
1Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
Correspondence: Dr. Masayuki Amagai, Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. E-mail: amagai@sc.itc.keio.ac.jp
Abstract
The endemic form of pemphigus foliaceus, fogo selvagem, is caused by IgG autoantibodies directed against desmoglein 1 (Dsg1). Hilario-Vargas and his colleagues describe a high prevalence of IgG autoantibodies against Dsg3, the target antigen of pemphigus vulgaris, in a Brazilian population where fogo selvagem is endemic, although those patients do not develop any apparent clinical phenotype of pemphigus vulgaris.
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
