Commentary
Journal of Investigative Dermatology (2006) 126, 1444–1447. doi:10.1038/sj.jid.5700281
HLA-Independent Antibacterial Host Response toward Th1 Immunity Mediated by IL-12: a New Concept for the Pathogenesis of Adamantiades–Behçet's Disease
Christos C Zouboulis1
- 1Departments of Dermatology and Immunology, Dessau Medical Center, Dessau, Germany;
- 2Laboratory of Biogerontology, Dermato-Pharmacology and Dermato-Endocrinology, Institute of Clinical Pharmacology and Toxicology, Charité Universitaetsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
Correspondence: Dr. Christos C. Zouboulis, Departments of Dermatology and Immunology, Dessau Medical Center, Auenweg 38, 06847 Dessau, Germany. E-mail: christos.zouboulis@klinikum-dessau.de
Abstract
Yanagihori et al. found an HLA-independent higher frequency of IL-12B promoter polymorphism in Adamantiades–Behçet's disease (ABD) patients than in controls. Stimulation with streptococcal antigens specifically increased expression of patients' peripheral blood mononuclear cells IL-12 p40/p70. The authors provide evidence for an antibacterial host response toward T-helper type 1 immunity mediated by IL-12 in patients with ABD, which is HLA independent.
