Commentary
Journal of Investigative Dermatology (2006) 126, 951–953. doi:10.1038/sj.jid.5700282
Lipid Rafts: Membrane Triage Centers
Xiao-qi Wang1 and Amy S Paller1
1Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
Correspondence: Dr. Amy S. Paller, Department of Dermatology, 645 N. Michigan Avenue, Suite 520, Chicago, Illinois 60611, USA. E-mail: apaller@northwestern.edu
Abstract
Both biochemical and live cell imaging studies suggest the existence of lipid rafts, specialized membrane microdomains that promote interaction among signaling molecules. Although their composition is still poorly understood, these highly dynamic domains are enriched in cholesterol, sphingolipids, and particular groups of proteins. The mechanism(s) by which trafficking into or out of lipid rafts affects signaling remains unclear.
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