TABLE 1
FROM:
Value of MLH1 and MSH2 Mutations in the Appearance of Muir–Torre Syndrome Phenotype in HNPCC Patients Presenting Sebaceous Gland Tumors or Keratoacanthomas
Giovanni Ponti, Lorena Losi, Monica Pedroni, Emanuela Lucci-Cordisco, Carmela Di Gregorio, Giovanni Pellacani and Stefania Seidenari
BACK TO ARTICLETable 1. Clinical features of MTS patients identified among HNPCC families
| Case | Sex | Skin lesion histology | Age at first skin lesion | Site | Visceral tumor in the proband (age) | Tumors in the family (age) |
|---|---|---|---|---|---|---|
| 1 | F | Sebaceous carcinoma | 46 | Back | — | Uterus 40 (sister) |
| Ovary 40 (sister) | ||||||
| Ovary 34 (daughter) | ||||||
| Rectum 29 (nephew) | ||||||
| 2 | M | Sebaceous epithelioma | 49 | Back | Colon 49 | Rectum 59 (father) |
| Colon 38 (mother) | ||||||
| 3 | M | Sebaceous carcinoma | 54 | Eyelid | Colon 48 | Colon 45 (brother) |
| Colon 38 (brother) | ||||||
| Uterus 40 (sister) | ||||||
| Bone 16 (nephew) | ||||||
| 4 | F | Sebaceous adenoma | 46 | Eyelid | Breast 38 | Colon 33 (mother) |
| Uterus 40 | Colon 39 (sister) | |||||
| Colon 45 | Colon 32 (brother) | |||||
| Stomach 42 (uncle) | ||||||
| Colon 37 (uncle) | ||||||
| Uterus 50; colon 48 (ant) | ||||||
| Uterus 33 (grandmother) | ||||||
| 5 | F | Keratoacanthoma | 63 | Nose | Colon 62 | Pancreas 60 (brother) |
| Pancreas 50 (brothers) | ||||||
| Breast (aunt) | ||||||
| Colonic adenomas (daughter) |
F, female; HNPCC, hereditary non-polyposis colorectal cancer; M, male; MTS, Muir–Torre syndrome.
