1. ¹Department of Preventive Medicine, Creighton University School of Medicine, Omaha, Nebraska, USA
2. ²Division of Dermatology, Creighton University Medical Center, Omaha, Nebraska, USA
3. ³Department of Dermatology, University of Nebraska Medical Center, Omaha, Nebraska, USA
4. ⁴Department of Gastrointestinal Medicine and Nutrition, University of Texas MD Anderson Cancer Center, Houston, Texas, USA

Correspondence: Dr. Henry T. Lynch, Department of Preventive Medicine, Creighton University School of Medicine, 2500 California Plaza, Omaha, Nebraska 68178, USA. E-mail: htlynch@creighton.edu

Abstract

Cutaneous lesions consonant with Muir–Torre syndrome strongly suggest hereditary non-polyposis colorectal cancer (HNPCC). Ponti et al. discuss the importance of combining molecular genetic features of the sebaceous neoplasms, including microsatellite instability and immunohistochemistry, with family history, to determine the likelihood of HNPCC. Proof of diagnosis is identification of one of the mismatch repair germline mutations.