Letter to the Editor
Journal of Investigative Dermatology (2006) 126, 2338–2342. doi:10.1038/sj.jid.5700379; published online 15 June 2006
Elevated Human Tissue Kallikrein Levels in the Stratum Corneum and Serum of Peeling Skin Syndrome-Type B Patients Suggests an Over-desquamation of Corneocytes
Nahoko Komatsu1,2,3,4, Yasushi Suga5, Kiyofumi Saijoh3, Amber C Liu1, Saba Khan1, Yuki Mizuno5, Shigaku Ikeda5, Hua-Kang Wu6, Arumugam Jayakumar6, Gary L Clayman6,7, Fumiaki Shirasaki4, Kazuhiko Takehara4 and Eleftherios P Diamandis1,2
- 1Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
- 2Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
- 3Department of Hygiene, Graduate School of Medical Science, School of Medicine, Kanazawa University, Kanazawa, Japan
- 4Department of Dermatology, Graduate School of Medical Science, School of Medicine, Kanazawa University, Kanazawa, Japan
- 5Department of Dermatology, Juntendo University School of Medicine, Tokyo, Japan
- 6Department of Head and Neck Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
- 7Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Correspondence: Eleftherios P. Diamandis, E-mail: ediamandis@mtsinai.on.ca
Abbreviations:
AMC, 7-amino-4-methyl-commarin; hK, kallikrein protein; NS, Netherton syndrome; pNA, para-nitroanilide; PSS, peeling skin syndrome; SC, stratum corneum; SPINK5, serine protease inhibitor Kazal-type 5
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