TABLE OF CONTENTS
Volume 122, Issue 3 (March 2004)
Editorials
Clinical Snippets FREE
Lowell A Goldsmith
J Invest Dermatol 122: vi-vi; doi:10.1111/j.1523-1747.2004.22347.x
See also: Original Article by Gallucci et al.In This Issue FREE
Paul R Bergstresser MD
J Invest Dermatol 122: vii-vii; doi:10.1111/j.0022-202X.2004.22348.x
See also: Original Article by Letsch et al.In That Issue: The Burden of Skin Disease FREE
Mary-Margaret Chren and Martin A Weinstock
J Invest Dermatol 122: viii-viii; doi:10.1111/j.0022-202X.2004.22349.x
Pseudoxanthoma Elasticum—A Connective Tissue Disease or a Metabolic Disorder at the Genome/Environment Interface? FREE
Jouni Uitto
J Invest Dermatol 122: ix-x; doi:10.1111/j.0022-202X.2004.22350.x
See also: Original Article by Chassaing et al.Close Shave for a Keratin Disorder—K6hf Polymorphism Linked to Pseudofolliculitis Barbae FREE
W H Irwin McLean
J Invest Dermatol 122: xi-xiii; doi:10.1111/j.0022-202X.2004.22351.x
Chemokine Receptors in Melanoma: CCR9 Has a Potential Role in Metastasis to the Small Bowel FREE
Sam T Hwang MD, PhD
J Invest Dermatol 122: xiv-xv; doi:10.1111/j.0022-202X.2004.22346.x
Original Articles
Appendages
Androgen Regulation of the Human Hair Follicle: The Type I Hair Keratin hHa7 Is a Direct Target Gene in Trichocytes FREE
Luis F Jave-suarez, Lutz Langbein, Hermelita Winter, Silke Praetzel, Michael A Rogers and Juergen Schweizer
J Invest Dermatol 122: 555-564; advance online publication, March 23, 2004; doi:10.1111/j.0022-202X.2004.22336.x
The RAIG Family Member, GPRC5D, Is Associated with Hard-Keratinized Structures FREE
Shinichi Inoue, Tadahiro Nambu and Toshiyasu Shimomura
J Invest Dermatol 122: 565-573; advance online publication, March 23, 2004; doi:10.1046/j.0022-202X.2004.12628.x
Clinical Research
Cellular Coincidence of Clonal T Cell Receptor Rearrangements and Complex Clonal Chromosomal Aberrations—A Hallmark of Malignancy in Cutaneous T Cell Lymphoma FREE
J Marcus Muche, Leena Karenko, Sylke Gellrich, Ritva Karhu, Soili Kytölä, Marketta Kähkönen, Ansgar Lukowsky, Wolfram Sterry and Annamari Ranki
J Invest Dermatol 122: 574-578; advance online publication, March 23, 2004; doi:10.1111/j.0022-202X.2004.22303.x
Genomic Aberrations and Survival in Cutaneous T Cell Lymphomas FREE
Tanja C Fischer, Sylke Gellrich, J Marcus Muche, Tumenjargal Sherev, Heike Audring, Heidemarie Neitzel, Peter Walden, Wolfram Sterry and Holger Tönnies
J Invest Dermatol 122: 579-586; advance online publication, March 23, 2004; doi:10.1111/j.0022-202X.2004.22301.x
The Prostaglandin E1 Analog Misoprostol Reduces Symptoms and Microvascular Arteriovenous Shunting in Erythromelalgia—A Double-Blind, Crossover, Placebo-Compared Study FREE
Cato Mørk, E Göran Salerud, Claes L Asker and Knut Kvernebo
J Invest Dermatol 122: 587-593; advance online publication, March 23, 2004; doi:10.1111/j.0022-202X.2004.22339.x
Novel Autoantibody to Cu/Zn Superoxide Dismutase in Patients with Localized Scleroderma FREE
Masaki Nagai, Minoru Hasegawa, Kazuhiko Takehara and Shinichi Sato
J Invest Dermatol 122: 594-601; advance online publication, March 23, 2004; doi:10.1111/j.0022-202X.2004.22333.x
Measures of Clinical Severity, Quality of Life, and Psychological Distress in Patients with Psoriasis: A Cluster Analysis FREE
Francesca Sampogna, Francesco Sera and Damiano Abeni
J Invest Dermatol 122: 602-607; doi:10.1046/j.0022-202X.2003.09101.x
Connective Tissue
Novel ABCC6 Mutations in Pseudoxanthoma Elasticum FREE
Nicolas Chassaing, Ludovic Martin, Juliette Mazereeuw, Laurence Barrié, Sonia Nizard, Jean-Louis Bonafé, Patrick Calvas and Alain Hovnanian
J Invest Dermatol 122: 608-613; advance online publication, March 23, 2004; doi:10.1111/j.0022-202X.2004.22312.x
See also: Editorial by UittoLocalization of the Laminin 
4 Chain in the Skin and Identification of a Heparin-Dependent Cell Adhesion Site Within the Laminin 4 Chain C-Terminal LG4 Module FREE
Hiroshi Matsuura, Yutaka Momota, Kaoru Murata, Hironori Matsushima, Nobuharu Suzuki, Motoyoshi Nomizu, Hiroshi Shinkai and Atsushi Utani
J Invest Dermatol 122: 614-620; advance online publication, March 23, 2004; doi:10.1111/j.0022-202X.2004.22325.x
Lysyl Oxidase-Like and Lysyl Oxidase Are Present in the Dermis and Epidermis of a Skin Equivalent and in Human Skin and Are Associated to Elastic Fibers FREE
Emmanuelle Noblesse, Valérie Cenizo, Charbel Bouez, Agnès Borel, Claudine Gleyzal, Simone Peyrol, Marie-Paule Jacob, Pascal Sommer and Odile Damour
J Invest Dermatol 122: 621-630; advance online publication, March 23, 2004; doi:10.1111/j.0022-202X.2004.22330.x
Differential Regulation by IL-1
and EGF of Expression of Three Different Hyaluronan Synthases in Oral Mucosal Epithelial Cells and Fibroblasts and Dermal Fibroblasts: Quantitative Analysis Using Real-Time RT-PCR FREE
Yoichi Yamada, Naoki Itano, Ken-ichiro Hata, Minoru Ueda and Koji Kimata
J Invest Dermatol 122: 631-639; advance online publication, March 23, 2004; doi:10.1111/j.0022-202X.2004.22332.x
Genetics
Variation at the IRF2 Gene and Susceptibility to Psoriasis in Chromosome 4q-Linked Families FREE
James Parkinson, Celine Charon, Barbara S Baker, Anne V Powles, Sarah Rogers, Ann Caird, Damian Smedley, Stephanie Halford, Lionel Fry and Mark I McCarthy
J Invest Dermatol 122: 640-643; doi:10.1046/j.0022-202X.2004.22135.x
Missed Calculations and New Conclusions: Re-Calculation of Genotype Distribution Data Published in Journal of Investigative Dermatology, 1998–2003 FREE
Balázs Györffy, István Kocsis and Barna Vásárhelyi
J Invest Dermatol 122: 644-646; advance online publication, March 23, 2004; doi:10.1111/j.0022-202X.2004.22334.x
Homozygous Splice Site Mutations in PKP1 Result in Loss of Epidermal Plakophilin 1 Expression and Underlie Ectodermal Dysplasia/Skin Fragility Syndrome in Two Consanguineous Families FREE
Eli Sprecher, Vered Molho-Pessach, Arieh Ingber, Efraim Sagi, Margarita Indelman and Reuven Bergman
J Invest Dermatol 122: 647-651; advance online publication, March 23, 2004; doi:10.1111/j.0022-202X.2004.22335.x
An Unusual Ala12Thr Polymorphism in the 1A -Helical Segment of the Companion Layer-Specific Keratin K6hf: Evidence for a Risk Factor in the Etiology of the Common Hair Disorder Pseudofolliculitis Barbae FREE
Hermelita Winter, Daniel Schissel, David A D Parry, Thomasin A Smith, Mirjana Liovic, E Birgitte Lane, Lutz Edler, Lutz Langbein, Luis F Jave-Suarez, Michael A Rogers, Joseph Wilde, Gerald Peters and Jürgen Schweizer
J Invest Dermatol 122: 652-657; doi:10.1111/j.0022-202X.2004.22309.x
Identification of the Cylindromatosis Tumor-Suppressor Gene Responsible for Multiple Familial Trichoepithelioma FREE
Xue-Jun Zhang, Yan-Hua Liang, Ping-Ping He, Sen Yang, Hong-Yan Wang, Jian-Jun Chen, Wen-Tao Yuan, Shi-Jie Xu, Yong Cui and Wei Huang
J Invest Dermatol 122: 658-664; advance online publication, March 23, 2004; doi:10.1111/j.0022-202X.2004.22321.x
Immunology/Infection
Psoriasis-Like Cutaneous Inflammation in Mice Lacking Interleukin-1 Receptor Antagonist FREE
Joanna Shepherd, Matthew C Little and Martin J H Nicklin
J Invest Dermatol 122: 665-669; advance online publication, March 23, 2004; doi:10.1111/j.0022-202X.2004.22305.x
Ontogeny of Langerin/CD207 Expression in the Epidermis of Mice FREE
Christoph H Tripp, Souyet Chang-Rodriguez, Patrizia Stoitzner, Sandra Holzmann, Hella Stössel, Patrice Douillard, Sem Saeland, Franz Koch, Adelheid Elbe-Bürger and Nikolaus Romani
J Invest Dermatol 122: 670-672; advance online publication, March 23, 2004; doi:10.1111/j.0022-202X.2004.22337.x
Corticosteroids But Not Pimecrolimus Affect Viability, Maturation and Immune Function of Murine Epidermal Langerhans Cells FREE
Wolfram Hoetzenecker, Josef G Meingassner, Rupert Ecker, Georg Stingl, Anton Stuetz and Adelheid Elbe-Bürger
J Invest Dermatol 122: 673-684; advance online publication, March 23, 2004; doi:10.1111/j.0022-202X.2004.22324.x
Functional CCR9 Expression Is Associated with Small Intestinal Metastasis FREE
Anne Letsch, Ulrich Keilholz, Dirk Schadendorf, Geraldine Assfalg, Anne Marie Asemissen, Eckhard Thiel and Carmen Scheibenbogen
J Invest Dermatol 122: 685-690; advance online publication, March 23, 2004; doi:10.1111/j.0022-202X.2004.22315.x
See also: Editorial by BergstresserUpregulation of 8-Lipoxygenase in the Dermatitis of I
B--Deficient Mice FREE
Claus Schneider, W David Strayhorn, Dana M Brantley, Lillian B Nanney, Fiona E Yull and Alan R Brash
J Invest Dermatol 122: 691-698; advance online publication, March 23, 2004; doi:10.1111/j.0022-202X.2004.22329.x
Characterizing the Protective Component of the T Cell Response to Transplantable Squamous Cell Carcinoma FREE
Michael Girardi, David Oppenheim, Earl J Glusac, Renata Filler, Allan Balmain, Robert E Tigelaar and Adrian C Hayday
J Invest Dermatol 122: 699-706; doi:10.1111/j.0022-202X.2004.22342.x
Human Single-Chain Antibodies Reactive with Native Chondroitin Sulfate Detect Chondroitin Sulfate Alterations in Melanoma and Psoriasis FREE
Toon F C M Smetsers, Els M A van de Westerlo, Gerdy B ten Dam, Ingrid M Overes, Joost Schalkwijk, Goos N P van Muijen and Toin H van Kuppevelt
J Invest Dermatol 122: 707-716; advance online publication, March 23, 2004; doi:10.1111/j.0022-202X.2004.22316.x
Keratinocytes/Epidermis
Interferon -Inducible Protein 27 (IFI27) is Upregulated in Psoriatic Skin and Certain Epithelial Cancers FREE
Sari Suomela, Li Cao, Anne Bowcock and Ulpu Saarialho-Kere
J Invest Dermatol 122: 717-721; doi:10.1111/j.0022-202X.2004.22322.x
Biosynthesis of Acylceramide in Murine Epidermis: Characterization by Inhibition of Glucosylation and Deglucosylation, and by Substrate Specificity FREE
Yutaka Takagi, Hidemi Nakagawa, Noboru Matsuo, Tomoko Nomura, Minoru Takizawa and Genji Imokawa
J Invest Dermatol 122: 722-729; doi:10.1111/j.0022-202X.2004.22307.x
A 4.2 kb Upstream Region of the Human Corneodesmosin Gene Directs Site-Specific Expression in Hair Follicles and Hyperkeratotic Epidermis of Transgenic Mice FREE
Hélène Gallinaro, Nathalie Jonca, Lutz Langbein, Christian Vincent, Michel Simon, Guy Serre and Marina Guerrin
J Invest Dermatol 122: 730-738; advance online publication, March 23, 2004; doi:10.1111/j.0022-202X.2004.22306.x
Effects of Relative Humidity and Ambient Temperature on the Ballistic Delivery of Micro-Particles to Excised Porcine Skin FREE
Mark Kendall, Stephen Rishworth, Fiona Carter and Thomas Mitchell
J Invest Dermatol 122: 739-746; advance online publication, March 23, 2004; doi:10.1111/j.0022-202X.2004.22320.x
Homo-Oligomerization of Human Corneodesmosin Is Mediated by Its N-Terminal Glycine Loop Domain FREE
Cécile Caubet, Nathalie Jonca, Frédéric Lopez, Jean-Pierre Estève, Michel Simon and Guy Serre
J Invest Dermatol 122: 747-754; advance online publication, March 23, 2004; doi:10.1111/j.0022-202X.2004.22331.x
Relationship Between NMF (Lactate and Potassium) Content and the Physical Properties of the Stratum Corneum in Healthy Subjects FREE
Noriaki Nakagawa, Shingo Sakai, Masayuki Matsumoto, Kenichi Yamada, Masahiro Nagano, Takuo Yuki, Yasushi Sumida and Hideyo Uchiwa
J Invest Dermatol 122: 755-763; advance online publication, March 23, 2004; doi:10.1111/j.0022-202X.2004.22317.x
Interleukin 6 Indirectly Induces Keratinocyte Migration FREE
Randle M Gallucci, Dusti K Sloan, Julie M Heck, Anne R Murray and Sijy J O'Dell
J Invest Dermatol 122: 764-772; advance online publication, March 23, 2004; doi:10.1111/j.0022-202X.2004.22323.x
See also: Editorial by GoldsmithKeratinocytes Rapidly Readjust Ceramide–Sphingomyelin Homeostasis and Contain a Phosphatidylcholine–Sphingomyelin Transacylase FREE
Reinhard Wanner, Matthias Peiser and Burghardt Wittig
J Invest Dermatol 122: 773-782; doi:10.1111/j.0022-202X.2004.22340.x
Mechanical Stretching In Vitro Regulates Signal Transduction Pathways and Cellular Proliferation in Human Epidermal Keratinocytes FREE
Shoichiro Yano, Mayumi Komine, Manabu Fujimoto, Hitoshi Okochi and Kunihiko Tamaki
J Invest Dermatol 122: 783-790; advance online publication, March 23, 2004; doi:10.1111/j.0022-202X.2004.22328.x
Regulation of MAPK Activation, AP-1 Transcription Factor Expression and Keratinocyte Differentiation in Wounded Fetal Skin FREE
Samantha Gangnuss, Allison J Cowin, Ilse S Daehn, Nick Hatzirodos, Joseph A Rothnagel, Antiopi Varelias and Timothy E Rayner
J Invest Dermatol 122: 791-804; advance online publication, March 23, 2004; doi:10.1111/j.0022-202X.2004.22319.x
Melanocytes/Melanoma
Aberrant Expression of the Maspin Gene Associated with Epigenetic Modification in Melanoma Cells FREE
Kei Wada, Chihaya Maesawa, Toshihide Akasaka and Tomoyuki Masuda
J Invest Dermatol 122: 805-811; advance online publication, March 23, 2004; doi:10.1111/j.0022-202X.2004.22308.x
Neurobiology
K252a, a High-Affinity Nerve Growth Factor Receptor Blocker, Improves Psoriasis: An In Vivo Study Using the Severe Combined Immunodeficient Mouse–Human Skin Model FREE
Siba P Raychaudhuri, Mrinmoy Sanyal, Helena Weltman and Smriti Kundu-Raychaudhuri
J Invest Dermatol 122: 812-819; advance online publication, March 23, 2004; doi:10.1111/j.0022-202X.2003.12602.x
Tumor Biology
CD158k/KIR3DL2 Is a New Phenotypic Marker of Sezary Cells: Relevance for the Diagnosis and Follow-Up of Sezary Syndrome FREE
Ewa Poszepczynska-Guigné, Valérie Schiavon, Michel D'Incan, Hamid Echchakir, Philippe Musette, Nicolas Ortonne, Laurence Boumsell, Alessandro Moretta, Armand Bensussan and Martine Bagot
J Invest Dermatol 122: 820-823; advance online publication, March 23, 2004; doi:10.1111/j.0022-202X.2004.22326.x
Vascular Biology
Circadian and Ultradian (12 h) Variations of Skin Blood Flow and Barrier Function in Non-Irritated and Irritated Skin—Effect of Topical Corticosteroids FREE
Gil Yosipovitch, Linda Sackett-Lundeen, Anthony Goon, Chan Yiong Huak, Chee Leok Goh and Erhard Haus
J Invest Dermatol 122: 824-829; advance online publication, March 23, 2004; doi:10.1111/j.0022-202X.2004.22313.x
Activated, Not Resting, Platelets Increase Leukocyte Rolling in Murine Skin Utilizing a Distinct Set of Adhesion Molecules FREE
Ralf J Ludwig, Jeanette E Schultz, Wolf-Henning Boehncke, Maurizio Podda, Christa Tandi, Fritz Krombach, Holger Baatz, Roland Kaufmann, Ulrich H von Andrian and Thomas M Zollner
J Invest Dermatol 122: 830-836; advance online publication, March 23, 2004; doi:10.1111/j.0022-202X.2004.22318.x
Letters to the Editor
A Novel Recessive Connexin 31 (GJB3) Mutation in a Case of Erythrokeratodermia Variabilis FREE
Alessandro Terrinoni, Aida Leta, Cristina Pedicelli, Eleonora Candi, Marco Ranalli, Pietro Puddu, Mauro Paradisi, Corrado Angelo, Giacinto Baggetta and Gerry Melino
J Invest Dermatol 122: 837-839; advance online publication, March 23, 2004; doi:10.1111/j.0022-202X.2004.22311.x
Estrogens and Human Scalp Hair Growth—Still More Questions than Answers FREE
Franziska Conrad, Ulrich Ohnemus, Enikö Bodo, Albrecht Bettermann and Ralf Paus
J Invest Dermatol 122: 840-842; advance online publication, March 23, 2004; doi:10.1111/j.0022-202X.2004.22344.x
Polymorphisms in the Promoter of the Interleukin-4 Receptor 
Chain Gene Are Associated with Atopic Dermatitis in Japan FREE
Naoko Hosomi, Kazuyoshi Fukai, Naoki Oiso, Atsushi Kato, Masamitsu Ishii, Hiroyuki Kunimoto and Koichi Nakajima
J Invest Dermatol 122: 843-845; advance online publication, March 23, 2004; doi:10.1111/j.0022-202X.2004.22338.x
Langerhans Cells in CD44-Deficient Mice Emigrate from the Epidermis But Fail to Reach the Lymph Nodes After Hapten Application FREE
Diana I Mummert, Akira Takashima and Mark E Mummert
J Invest Dermatol 122: 846-847; doi:10.1046/j.0022-202X.2004.22127.x
A Soy-Derived Immunostimulating Peptide Inhibits Etoposide-Induced Alopecia in Neonatal Rats FREE
Takahiro Tsuruki, Kyoya Takahata and Masaaki Yoshikawa
J Invest Dermatol 122: 848-850; advance online publication, March 23, 2004; doi:10.1111/j.0022-202X.2004.22310.x
Presence of a Sporadic Case of Systemic Granulomatosis Syndrome with a CARD15 Mutation FREE
Nobuo Kanazawa, Satoko Matsushima, Naotomo Kambe, Takao Tachibana, Sonoko Nagai and Yoshiki Miyachi
J Invest Dermatol 122: 851-852; advance online publication, March 23, 2004; doi:10.1111/j.0022-202X.2004.22341.x
Population Attributable Fraction Estimates of Familial Risk in Cutaneous Melanoma FREE
Annette Pfahlberg, Wolfgang Uter and Olaf Gefeller
J Invest Dermatol 122: 853-854; advance online publication, March 23, 2004; doi:10.1111/j.0022-202X.2004.22314.x
Researcher Opinions on Human Embryonic Stem Cell Issues FREE
Amanda L Drake, Lauren F Heilig, Katarzyna Z Kozak, Eric J Hester and Robert P Dellavalle
J Invest Dermatol 122: 855-856; advance online publication, March 23, 2004; doi:10.1111/j.0022-202X.2004.22343.x
Insuring Rapid and Robust Safety Assessment FREE
Robert S Stern and Tamar Njisten
J Invest Dermatol 122: 857-858; doi:10.1111/j.0022-202X.2004.22345.x
The Cell Infiltrate in Lymphomatoid Papulosis Comprises a Mixture of Polyclonal Large Atypical Cells (CD30-Positive) and Smaller Monoclonal T cells (CD30-Negative) FREE
Sylke Gellrich, Martin Wernicke, Anke Wilks, Ansgar Lukowsky, J Marcus Muche, Kim Christian Jasch, Heike Audring, David Mason and Wolfram Sterry
J Invest Dermatol 122: 859-861; advance online publication, March 23, 2004; doi:10.1111/j.0022-202X.2004.22304.x
