Original Article
Subject Categories: Tumor Biology
Journal of Investigative Dermatology (2004) 122, 820–823; doi:10.1111/j.0022-202X.2004.22326.x
CD158k/KIR3DL2 Is a New Phenotypic Marker of Sezary Cells: Relevance for the Diagnosis and Follow-Up of Sezary Syndrome
Ewa Poszepczynska-Guigné*,†, Valérie Schiavon*, Michel D'Incan‡, Hamid Echchakir*, Philippe Musette§, Nicolas Ortonne*, Laurence Boumsell*, Alessandro Moretta¶, Armand Bensussan*,1 and Martine Bagot*,†,1
- *INSERM U448, Hôpital Henri Mondor, Créteil, France
- †Department of Dermatology, Hôpital Henri Mondor, Créteil, France
- ‡Department of Dermatology, Clermont-Ferrand, France
- §Department of Dermatology, Rouen, France
- ¶Dipartimento di Medicina Sperimentale, Università di Genova, Genova, Italy. French Cutaneous Lymphoma Study Group
Correspondence: Dr Ewa Poszepczynska-Guigné, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil Cedex, France. Email: ewa.guigne@libertysurf.fr
1Contributed equally as senior authors.
Received 1 July 2003; Revised 9 October 2003; Accepted 22 October 2003; Published online 23 March 2004.
Abstract
CD158k molecules belong to the family of killer cell immunoglobulin-like receptors (KIR) that are expressed on a minor population of circulating NK and CD8+ T lymphocytes. Here, we report a strong positive correlation between the percentage of CD158k+ blood lymphocytes analyzed by flow cytometry and the percentage of atypical circulating cells (Sezary cells) determined by cytomorphology in a large group of patients with Sezary syndrome. Moreover, we show that circulating CD4+CD158k+ lymphocytes correspond to the malignant clonal cell population. Our findings suggest that the CD158k marker could be a useful tool for the evaluation of the circulating tumoral burden and the follow-up of patients with Sezary syndrome.
Keywords:
cutaneous lymphoma, Sezary syndrome, Sezary cells, CD158k, KIR3DL2, tumor marker
Abbreviations:
KIR, killer cell immunoglobulin-like receptors; mAb, monoclonal antibodies; PBMC, peripheral blood mononuclear cells; SS, Sezary syndrome
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