TABLE OF CONTENTS

Volume 122, Issue 2 (February 2004)

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Remembering Thomas B. Fitzpatrick

Remembering Thomas Fitzpatrick FREE

Brian J Nickoloff

J Invest Dermatol 122: xxv-xxv; doi:10.1046/j.1523-1747.2003.22257.x

Dr Fitzpatrick's Influence in Japanese Dermatology FREE

Atsushi Kukita

J Invest Dermatol 122: xvi-xvii; doi:10.1046/j.1523-1747.2003.22250.x

Melanocyte Biology: Before, During, and After the Fitzpatrick Era FREE

Mina Yaar and Barbara A Gilchrest

J Invest Dermatol 122: xxvii-xxix; doi:10.1046/j.1523-1747.2003.22256.x

Melanoma Before and After Thomas B. Fitzpatrick FREE

Martin C Mihm Jr., and Arthur J Sober

J Invest Dermatol 122: xxxii-xxxiii; doi:10.1046/j.1523-1747.2003.22252.x

Chai – Eighteen Quotations for TBF FREE

Lowell A Goldsmith

J Invest Dermatol 122: vii-viii; doi:10.1111/j.1523-1747.2003.22245.x

The Thomas B. Fitzpatrick Professorship at Harvard Medical School FREE

Thomas Kupper

J Invest Dermatol 122: xv-xv; doi:10.1111/j.0022-202X.2004.22249.x

Thomas B Fitzpatrick MD: 1948–51: The Residency Years and Preparation for Doctoral Thesis: Mayo Clinic FREE

Mark D P Davis, Clark C Otley, Mark R Pittelkow, Marian T McEvoy and Randall K Roenigk

J Invest Dermatol 122: xxii-xxiv; doi:10.1046/j.1523-1747.2003.22255.x

We Came Over on the Boat Together FREE

Aaron B Lerner

J Invest Dermatol 122: xi-xiv; doi:10.1046/j.0022-202X.2004.22232.x

In Memory of Thomas Bernhard Fitzpatrick FREE

Madhu A Pathak

J Invest Dermatol 122: xx-xxi; doi:10.1046/j.1523-1747.2003.22248.x

The Epidermal Permeability Barrier: From the Early Days at Harvard to Emerging Concepts FREE

Peter M Elias

J Invest Dermatol 122: xxxvi-xxxix; doi:10.1046/j.0022-202X.2004.22233.x

Fitzpatrick's Impact on Photobiology and Photomedicine FREE

John A Parrish

J Invest Dermatol 122: ix-x; doi:10.1046/j.1523-1747.2003.22254.x

PUVA and the International Nature of Dr Fitzpatrick's Influence FREE

Klaus Wolff

J Invest Dermatol 122: xviii-xix; doi:10.1111/j.1523-1747.2004.22259.x

Clinical Snippets FREE

Lowell A Goldsmith

J Invest Dermatol 122: xliii-xliii; doi:10.1111/j.1523-1747.2004.22246.x

Skin Phototypes 2003 FREE

Susanne Astner and R Rox Anderson

J Invest Dermatol 122: xxx-xxxi; doi:10.1046/j.1523-1747.2003.22251.x

Piebaldism and Neurofibromatosis Type 1: Horses of Very Different Colors FREE

Richard A Spritz, Peter H Itin and David H Gutmann

J Invest Dermatol 122: xxxiv-xxxv; doi:10.1046/j.0022-202X.2004.22235.x

The Honorary Doctor Fitzpatrick FREE

Lowell A Goldsmith

J Invest Dermatol 122: xl-xli; doi:10.1111/j.1523-1747.2004.22234.x

TBF and DIGM FREE

Irwin M Freedberg

J Invest Dermatol 122: xxvi-xxvi; doi:10.1046/j.1523-1747.2003.22253.x

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Original Articles

Appendages

Wnt Signaling through the beta-Catenin Pathway Is Sufficient to Maintain, but Not Restore, Anagen-Phase Characteristics of Dermal Papilla Cells FREE

Hidenao Shimizu and Bruce A Morgan

J Invest Dermatol 122: 239-245; advance online publication, February 12, 2004; doi:10.1046/j.0022-202X.2004.22224.x

Clinical Research

Geographic and Patient Variation in Receipt of Surveillance Procedures After Local Excision of Cutaneous Melanoma  FREE

David A Barzilai, Kevin D Cooper, Duncan Neuhauser, Alfred A Rimm and Gregory S Cooper

J Invest Dermatol 122: 246-255; advance online publication, February 12, 2004; doi:10.1046/j.0022-202X.2004.22238.x

Connective Tissue

Elastin-Derived Peptides Upregulate Matrix Metalloproteinase-2-ediated Melanoma Cell Invasion Through Elastin-Binding Protein FREE

Carole Ntayi, Anne-Laure Labrousse, Romain Debret, Philipe Birembaut, Georges Bellon, Frank Antonicelli, William Hornebeck and Philipe Bernard

J Invest Dermatol 122: 256-265; advance online publication, February 12, 2004; doi:10.1046/j.0022-202X.2004.22228.x

Fibroblast Invasive Migration into Fibronectin/Fibrin Gels Requires a Previously Uncharacterized Dermatan Sulfate-CD44 Proteoglycan FREE

Richard A F Clark, Fubao Lin, Doris Greiling, Jianqang An and John R Couchman

J Invest Dermatol 122: 266-277; advance online publication, February 12, 2004; doi:10.1046/j.0022-202X.2004.22205.x

Matrix Metalloproteinase 9 Expression is Coordinately Modulated by the KRE-M9 and 12-O-Tetradecanoyl-Phorbol-13-Acetate Responsive Elements FREE

Takashi Kobayashi, Jiro Kishimoto, Shunji Hattori, Hiroshi Wachi, Hiroshi Shinkai and Robert E Burgeson

J Invest Dermatol 122: 278-285; advance online publication, February 12, 2004; doi:10.1046/j.0022-202X.2004.22210.x

Genetics

A Gene for Freckles Maps to Chromosome 4q32–q34 FREE

Xue-Jun Zhang, Ping-Ping He, Yan-Hua Liang, Sen Yang, Wen-Tao Yuan, Shi-Jie Xu and Wei Huang

J Invest Dermatol 122: 286-290; doi:10.1046/j.0022-202X.2004.22244.x

Immunology/Infection

Ultraviolet Radiation Causes Less Immunosuppression in Patients with Polymorphic Light Eruption Than in Controls FREE

Roy A Palmer and Peter S Friedmann

J Invest Dermatol 122: 291-294; advance online publication, February 12, 2004; doi:10.1046/j.0022-202X.2004.22213.x

Ultraviolet-Radiation-Induced Erythema and Suppression of Contact Hypersensitivity Responses in Patients with Polymorphic Light Eruption FREE

Chantalle B Van de Pas, Deirdre A Kelly, Paul T Seed, Antony R Young, John L M Hawk and Susan L Walker

J Invest Dermatol 122: 295-299; advance online publication, February 12, 2004; doi:10.1046/j.0022-202X.2004.22201.x

Ultraviolet B Radiation Suppresses Endocytosis, Subsequent Maturation, and Migration Activity of Langerhans Cell-Like Dendritic Cells FREE

Kana Mizuno, Hiroyuki Okamoto and Takeshi Horio

J Invest Dermatol 122: 300-306; advance online publication, February 12, 2004; doi:10.1046/j.0022-202X.2004.22206.x

Perturbed 6-Tetrahydrobiopterin Recycling via Decreased Dihydropteridine Reductase in Vitiligo: More Evidence for H2O2 Stress FREE

Sybille Hasse, Nicholas C J Gibbons, Hartmut Rokos, Lee K Marles and Karin U Schallreuter

J Invest Dermatol 122: 307-313; advance online publication, February 12, 2004; doi:10.1046/j.0022-202X.2004.22230.x

Keratinocytes/Epidermis

Basis For Abnormal Desquamation And Permeability Barrier Dysfunction in RXLI FREE

Peter M Elias, Debra Crumrine, Ulrich Rassner, Jean-Pierre Hachem, Gopinathan K Menon, Wenyan Man, Monica Hoi Wun Choy, Laura Leypoldt, Kenneth R Feingold and Mary L Williams

J Invest Dermatol 122: 314-319; doi:10.1046/j.1523-1747.2003.22258.x

Stratum Corneum Acidification in Neonatal Skin: Secretory Phospholipase A2 and the Sodium/Hydrogen Antiporter-1 Acidify Neonatal Rat Stratum Corneum FREE

Joachim W Fluhr, Martin J Behne, Barbara E Brown, David G Moskowitz, Clare Selden, Man Mao-Qiang, Theodora M Mauro, Peter M Elias and Kenneth R Feingold

J Invest Dermatol 122: 320-329; advance online publication, February 12, 2004; doi:10.1046/j.0022-202X.2003.00204.x

Imiquimod-Induced Interleukin-1alpha Stimulation Improves Barrier Homeostasis in Aged Murine Epidermis FREE

Chantel O Barland, Elizabeth Zettersten, Barbara S Brown, Jianqin Ye, Peter M Elias and Ruby Ghadially

J Invest Dermatol 122: 330-336; advance online publication, February 12, 2004; doi:10.1046/j.0022-202X.2004.22203.x

Melanocytes/Melanoma

Genetic Interaction Between NRAS and BRAF Mutations and PTEN/MMAC1 Inactivation in Melanoma FREE

Hensin Tsao, Vikas Goel, Heng Wu, Guang Yang and Frank G Haluska

J Invest Dermatol 122: 337-341; advance online publication, February 12, 2004; doi:10.1046/j.0022-202X.2004.22243.x

BRAF Mutations Are Common Somatic Events in Melanocytic Nevi  FREE

Rajiv Kumar, Sabrina Angelini, Erna Snellman and Kari Hemminki

J Invest Dermatol 122: 342-348; advance online publication, February 12, 2004; doi:10.1046/j.0022-202X.2004.22225.x

Terpinen-4-ol, The Main Component of Melaleuca Alternifolia (Tea Tree) Oil Inhibits the In Vitro Growth of Human Melanoma Cells FREE

Annarica Calcabrini, Annarita Stringaro, Laura Toccacieli, Stefania Meschini, Manuela Marra, Marisa Colone, Giuseppe Salvatore, Francesca Mondello, Giuseppe Arancia and Agnese Molinari

J Invest Dermatol 122: 349-360; advance online publication, February 12, 2004; doi:10.1046/j.0022-202X.2004.22236.x

Discrimination of Melanocytic Tumors by cDNA Array Hybridization of Tissues Prepared by Laser Pressure Catapulting FREE

Bernd Becker, Alexander Roesch, Christian Hafner, Wilhelm Stolz, Martin Dugas, Michael Landthaler and Thomas Vogt

J Invest Dermatol 122: 361-368; advance online publication, February 12, 2004; doi:10.1046/j.0022-202X.2004.22240.x

Downregulation of BRCA1 in A375 Melanoma Cell Line Increases Radio-Sensitivity and Modifies Metastatic and Angiogenic Gene Expression FREE

Cédric Hesling, Michel D'Incan, Chantal D'Incan, Pierre Souteyrand, Jean-Claude Monboisse, Sylvie Pasco, Jean-Claude Madelmont and Yves Jean Bignon

J Invest Dermatol 122: 369-380; doi:10.1046/j.0022-202X.2004.22212.x

In-Situ Imaging Mass Spectrometry Analysis of Melanin Granules in the Human Hair Shaft FREE

Philippe Hallégot, Ralph Peteranderl and Claude Lechene

J Invest Dermatol 122: 381-386; advance online publication, February 12, 2004; doi:10.1046/j.0022-202X.2004.22217.x

CpG Oligonucleotides Elicit Antitumor Responses in a Human Melanoma NOD/SCID Xenotransplantation Model FREE

Clemens Krepler, Volker Wacheck, Sabine Strommer, Gunther Hartmann, Peter Polterauer, Klaus Wolff, Hubert Pehamberger and Burkhard Jansen

J Invest Dermatol 122: 387-391; advance online publication, February 12, 2004; doi:10.1046/j.0022-202X.2004.22202.x

The Melanoma Inhibitor of Apoptosis Protein: A Target for Spontaneous Cytotoxic T Cell Responses FREE

Mads Hald Andersen, Sine Reker, Jürgen C Becker and Per thor Straten

J Invest Dermatol 122: 392-399; advance online publication, February 12, 2004; doi:10.1046/j.0022-202X.2004.22242.x

Imatinib Mesylate Inhibits Platelet-Derived Growth Factor Receptor Phosphorylation of Melanoma Cells But Does Not Affect Tumorigenicity In Vivo  FREE

Eric C Mcgary, Amir Onn, Lisa Mills, Amy Heimberger, Omar Eton, Gary W Thomas, Mikhail Shtivelband and Menashe Bar-Eli

J Invest Dermatol 122: 400-405; advance online publication, February 12, 2004; doi:10.1046/j.0022-202X.2004.22231.x

RPE65 of Retinal Pigment Epithelium, A Putative Receptor Molecule for Plasma Retinol-Binding Protein, is Expressed in Human Keratinocytes FREE

Gabriele Hinterhuber, Karla Cauza, Karin Brugger, Ruth Dingelmaier-hovorka, Reinhard Horvat, Klaus Wolff and Dagmar Foedinger

J Invest Dermatol 122: 406-413; advance online publication, February 12, 2004; doi:10.1046/j.0022-202X.2004.22216.x

Interferon-bold gamma-Mediated Growth Regulation of Melanoma Cells: Involvement of STAT1-Dependent and STAT1-Independent Signals FREE

Marcin Kortylewski, Waraporn Komyod, Maria-Elisabeth Kauffmann, Anja Bosserhoff, Peter C Heinrich and Iris Behrmann

J Invest Dermatol 122: 414-422; doi:10.1046/j.0022-202X.2004.22237.x

Quantitative Measures of the Effect of the Melanocortin 1 Receptor on Human Pigmentary Status  FREE

Lisa Naysmith, Karen Waterston, Tom Ha, Niamh Flanagan, Yvonne Bisset, Amanda Ray, Kazumasa Wakamatsu, Shosuke Ito and Jonathan L Rees

J Invest Dermatol 122: 423-428; advance online publication, February 12, 2004; doi:10.1046/j.0022-202X.2004.22221.x

An Assessment of a Variant of the DNA Repair Gene XRCC3 as a Possible Nevus or Melanoma Susceptibility Genotype FREE

Chandra Gooptu Bertram, Rupert M Gaut, Jennifer H Barrett, Juliette Randerson-Moor, Linda Whitaker, Faye Turner, Veronique Bataille, Isabel dos Santos Silva, Anthony J Swerdlow, D Timothy Bishop and Julia A Newton bishop

J Invest Dermatol 122: 429-432; advance online publication, February 12, 2004; doi:10.1046/j.0022-202X.2003.12541.x

Epidermal and Hair Follicle Progenitor Cells Express Melanoma-Associated Chondroitin Sulfate Proteoglycan Core Protein FREE

Lucy Ghali, Soon-Tee Wong, Nick Tidman, Anthony Quinn, Michael P Philpott and Irene M Leigh

J Invest Dermatol 122: 433-442; advance online publication, February 12, 2004; doi:10.1046/j.0022-202X.2004.22207.x

Melanoma Diagnosis by Raman Spectroscopy and Neural Networks: Structure Alterations in Proteins and Lipids in Intact Cancer Tissue FREE

Monika Gniadecka, Peter Alshede Philipsen, Sigurdur Sigurdsson, Sonja Wessel, Ole Faurskov Nielsen, Daniel Højgaard Christensen, Jana Hercogova, Kristian Rossen, Henrik Klem Thomsen, Robert Gniadecki, Lars Kai Hansen and Hans Christian Wulf

J Invest Dermatol 122: 443-449; advance online publication, February 12, 2004; doi:10.1046/j.0022-202X.2004.22208.x

CDKN2A: The IVS2-105A/G Intronic Mutation Found in an Italian Patient Affected by Eight Primary Melanomas FREE

Silvia Majore, Caterina Catricalà, Francesco Binni, Paola De Simone, Laura Eibenschutz and Paola Grammatico

J Invest Dermatol 122: 450-451; advance online publication, February 12, 2004; doi:10.1046/j.0022-202X.2004.22222.x

Characterization of Melanosomes in Murine Hermansky–Pudlak Syndrome: Mechanisms of Hypopigmentation FREE

Thuyen Nguyen and Maria L Wei

J Invest Dermatol 122: 452-460; doi:10.1046/j.0022-202X.2004.22117.x

Regulation of Human Melanoma Growth and Metastasis by AGE–AGE Receptor Interactions FREE

Riichiro Abe, Tadamichi Shimizu, Hiroshi Sugawara, Hirokazu Watanabe, Hideki Nakamura, Hiroshi Choei, Nobuyuki Sasaki, Sho-ichi Yamagishi, Masayoshi Takeuchi and Hiroshi Shimizu

J Invest Dermatol 122: 461-467; advance online publication, February 12, 2004; doi:10.1046/j.0022-202X.2004.22218.x

Photobiology

Solar-Simulated Ultraviolet Radiation-Induced Upregulation of the Melanocortin-1 Receptor, Proopiomelanocortin, and alpha-Melanocyte-Stimulating Hormone in Human Epidermis In Vivo  FREE

Meinhard Schiller, Thomas Brzoska, Markus Böhm, Dieter Metze, Thomas E Scholzen, André Rougier and Thomas A Luger

J Invest Dermatol 122: 468-476; doi:10.1046/j.0022-202X.2004.22239.x

Different Susceptibility of Malignant versus Nonmalignant Human T Cells Toward Ultraviolet A-1 Radiation-Induced Apoptosis FREE

Ritsuko Yamauchi, Akimichi Morita, Yoko Yasuda, Susanne Grether-Beck, Lars-Oliver Klotz, Takuo Tsuji and Jean Krutmann

J Invest Dermatol 122: 477-483; advance online publication, February 12, 2004; doi:10.1046/j.0022-202X.2003.22106.x

A Synthetic Superoxide Dismutase/Catalase Mimetic (EUK-134) Inhibits Membrane-Damage-Induced Activation of Mitogen-Activated Protein Kinase Pathways and Reduces p53 Accumulation in Ultraviolet B-Exposed Primary Human Keratinocytes FREE

David Decraene, Katrien Smaers, David Gan, Tom Mammone, Mary Matsui, Daniel Maes, Lieve Declercq and Marjan Garmyn

J Invest Dermatol 122: 484-491; advance online publication, February 12, 2004; doi:10.1046/j.0022-202X.2004.22215.x

Spectral Responses of Melanin to Ultraviolet A Irradiation FREE

Hao Ou-Yang, Georgios Stamatas and Nikiforos Kollias

J Invest Dermatol 122: 492-496; advance online publication, February 12, 2004; doi:10.1046/j.0022-202X.2004.22247.x

p38 Mitogen-Activated Protein Kinase Inhibitor Protects the Epidermis Against the Acute Damaging Effects of Ultraviolet Irradiation by Blocking Apoptosis and Inflammatory Responses FREE

Jeffrey Hildesheim, Rania T Awwad and Albert J Fornace Jr.,

J Invest Dermatol 122: 497-502; advance online publication, February 12, 2004; doi:10.1111/j.1523-1747.2004.22229.x

Involvement of Photooxidation of Melanogenic Precursors in Prolonged Pigmentation Induced by Ultraviolet A FREE

Kazuhisa Maeda and Masato Hatao

J Invest Dermatol 122: 503-509; advance online publication, February 12, 2004; doi:10.1046/j.0022-202X.2004.22223.x

Dietary Lutein Reduces Ultraviolet Radiation-Induced Inflammation and Immunosuppression FREE

Erica H Lee, Dorothea Faulhaber, Kerry M Hanson, Wanhong Ding, Sara Peters, Sreedevi Kodali and Richard D Granstein

J Invest Dermatol 122: 510-517; advance online publication, February 12, 2004; doi:10.1046/j.0022-202X.2004.22227.x

Mechanisms of Microvascular Response to Laser Pulses FREE

Kittisak Suthamjariya, William A Farinelli, Wooseok Koh and R Rox Anderson

J Invest Dermatol 122: 518-525; advance online publication, February 12, 2004; doi:10.1046/j.0022-202X.2004.22241.x

Trichothiodystrophy Fibroblasts Are Deficient in the Repair of Ultraviolet-Induced Cyclobutane Pyrimidine Dimers and (6–4)Photoproducts FREE

Yoko Nishiwaki, Nobuhiko Kobayashi, Kyoko Imoto, Taka-aki Iwamoto, Aya Yamamoto, Sachiko Katsumi, Toshihiko Shirai, Shigeki Sugiura, Yu Nakamura, Alain Sarasin, Sachiko Miyagawa and Toshio Mori

J Invest Dermatol 122: 526-532; advance online publication, February 12, 2004; doi:10.1046/j.0022-202X.2004.22226.x

Expression Profiling of Human Keratinocyte Response to Ultraviolet A: Implications in Apoptosis FREE

Yu-Ying He, Jian-Li Huang, Robert H Sik, Jie Liu, Michael P Waalkes and Colin F Chignell

J Invest Dermatol 122: 533-543; advance online publication, February 12, 2004; doi:10.1046/j.0022-202X.2003.22123.x

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Letters to the Editor

Validity Issues with the In Vivo Measurement of Skin Carotenoids Using Raman Spectroscopy FREE

Billy R Hammond Jr., and Billy R Wooten

J Invest Dermatol 122: 544-546; advance online publication, February 12, 2004; doi:10.1046/j.0022-202X.2004.22219.x

See also: Letter to the Editor by Gellermann et al.

Author response FREE

Werner Gellermann, Igor V Ermakov and Paul Bernstein

J Invest Dermatol 122: 546-548; advance online publication, February 12, 2004; doi:10.1046/j.0022-202X.2004.22220.x

See also: Letter to the Editor by Hammond & Wooten

High-Efficiency Stable Gene Transduction in Primary Human Melanocytes Using a Lentiviral Expression System FREE

Shariff Dunlap, Xiaobing Yu, Linzhao Cheng, Curt I Civin and Rhoda M Alani

J Invest Dermatol 122: 549-551; advance online publication, February 12, 2004; doi:10.1046/j.0022-202X.2004.22214.x

Langerhans Cells Integrated into Human Reconstructed Epidermis Respond to Known Sensitizers and Ultraviolet Exposure FREE

Valérie Facy, Virginie Flouret, Marcelle Régnier and Rainer Schmidt

J Invest Dermatol 122: 552-553; advance online publication, February 12, 2004; doi:10.1046/j.0022-202X.2004.22209.x

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