Journal of Investigative Dermatology

FIGURE 2

FROM:

Animal Model of Sclerotic Skin. I: Local Injections of Bleomycin Induce Sclerotic Skin Mimicking Scleroderma

Toshiyuki Yamamoto, Shinsuke Takagawa, Ichiro Katayama, Kenshi Yamazaki, Yoichiro Hamazaki, Hiroshi Shinkai and Kiyoshi Nishioka

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Figure 2.

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Dermal thickness in BALB/C mice treated with bleomycin. Mice were injected with 1 mg BLM per ml (dose per day, n = 6) (U25CF;) or PBS alone (n = 5) (circle). Dermal thickness gradually increased as the sclerosis developed, whereas PBS-treated mice did not exhibit an increase of dermal thickness. Significant differences were noted after 3 wk. * p < 0.05.

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