Original Article

Journal of Investigative Dermatology (1996) 107, 373–376; doi:10.1111/1523-1747.ep12363352

HLA-DR5 and DQB1*03 Class II Alleles Are Associated With Cutaneous T-Cell Lymphoma

Clotilde M Jackow1, Joan Breuer Mc Ham1, Allison Friss1, Joel Alvear1, John R Reveille2 and Madeleine Duvic1,2,3

  1. 1Department of Dermatology, University of Texas Medical School, Houston, Texas, U.S.A.
  2. 2Department of internal Medicine, University of Texas Medical School, Houston, Texas, U.S.A.
  3. 3Section of Dermatology, Division of Medicine, M.D. Anderson Cancer Center, Houston, Texas, U.S.A.

Received 13 December 1995; Revised 17 April 1996; Accepted 14 May 1996.

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Abstract

Cutaneous T-cell lymphoma (CTCL) may present with eczematous lesions, mycosis fungoides (MF), or as exfoliative erythroderma with circulating atypical cells, Sezary syndrome (SS). The "malignant" T cells are epidermotropic and clonal, but whether they respond to antigen stimulation is unknown. Because CD4+ lymphocytes recognize antigen presented by histocompatibility locus antigen (HLA) class II molecules, and HLA associations have been found in autoimmune skin diseases, we determined by allele-specific oligonucleotide typing whether HLA-DR or DQ alleles were associated with CTCL and its two variants MF (n = 47) and SS (n = 23). Phenotypic frequencies were compared by chi-square and Fisher exact test, and p values were corrected independently for either 12 DR or 15 DQ alleles. HLA-DR5, previously associated with MF, was significantly increased in all 70 CTCL patients (31.5%) versus controls (11%) (uncorrected p value [pnc] = 0.000038, odds ratio [OR] = 3.9, 1.9<OR<8.1), in MF patients (34%) (pnc] = 0.000047, OR = 3.62, 1.9<OR<10), and in SS patients (26%) (pnc] = 0.03, OR = 3, 0.9<OR<9.3). HLA-DQB1*03 alleles (0301, 0302, and 0303) were increased in 72% of all CTCL patients versus 49% of controls (corrected p value [pc] = 0.014, OR = 2.7, 1.4<OR<5.1), in SS (82%) (pc] = 0.05, OR = 4.7, 1.4<OR<5), and in MF (67%) (pnc] = 0.024, OR = 2.15, 1<OR<4.5). DQB1*0502 was strongly increased in SS patients (pc] = 0.045, OR 7.75, 1.25<OR<48). Although HLA-DQB1*0603 and HLA-DR6 (1301, 1302, and 1402) were decreased in all groups, the decreases were not statistically significant. These data suggest that certain HLA-DRB and DQB1 alleles, also associated with other T-cell-mediated skin diseases, may participate in the pathogenesis of or susceptibility to CTCL.

Keywords:

cancer, HLA disease association, mycosis fungoides, Sezary syndrome

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