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Developmental origins of health and disease: experimental and human evidence of fetal programming for metabolic syndrome

Journal of Human Hypertension volume 26, pages 405–419 (2012)Cite this article

Abstract

The concept of developmental origins of health and disease has been defined as the process through which the environment encountered before birth, or in infancy, shapes the long-term control of tissue physiology and homeostasis. The evidence for programming derives from a large number of experimental and epidemiological observations. Several nutritional interventions during diverse phases of pregnancy and lactation in rodents are associated with fetal and neonatal programming for metabolic syndrome. In this paper, recent experimental models and human epidemiological studies providing evidence for the fetal programming associated with the development of metabolic syndrome and related diseases are revisited.

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  1. Department of Anatomy, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, Brazil

    M L de Gusmão Correia, A M Volpato, M B Águila & C A Mandarim-de-Lacerda

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  1. M L de Gusmão Correia
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de Gusmão Correia, M., Volpato, A., Águila, M. et al. Developmental origins of health and disease: experimental and human evidence of fetal programming for metabolic syndrome. J Hum Hypertens 26, 405–419 (2012). https://doi.org/10.1038/jhh.2011.61

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