Original Article

Journal of Human Hypertension (2010) 24, 617–622; doi:10.1038/jhh.2009.104; published online 24 December 2009

Neuropeptide Y gene functional polymorphism influences susceptibility to hypertension in Indian population

L V K S Bhaskar1,4, K Thangaraj1, A L Non2, K Praveen Kumar1, G Pardhasaradhi1, L Singh1 and V R Rao3

  1. 1Centre for Cellular and Molecular Biology, Hyderabad, India
  2. 2Department of Anthropology, University of Florida, Gainesville, FL, USA
  3. 3Anthropological Survey of India, Kolkata, India
  4. 4Department of Biomedical Sciences, Sri Ramachandra University, Chennai, India

Correspondence: Dr VR Rao, Anthropological Survey of India, 27-Jawaharlal Nehru Road, Kolkata 700 016, India. E-mail: drraovr@yahoo.com

Received 7 September 2009; Revised 27 October 2009; Accepted 14 November 2009; Published online 24 December 2009.

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Abstract

Hypertension is an independent determinant of cardiovascular risk, a phenotype that usually has a strong genetic component. Neuropeptide Y (NPY) plays an important role in BP homeostasis. The aim of this study was to investigate the possible influence of NPY polymorphisms on hypertension in a South Indian population. A total of 252 subjects (132 controls and 120 hypertensives) were analysed for T1128C, G1258A and A7735G polymorphisms in the NPY gene. Body mass index (BMI), pulse, SBP and DBP were assessed. Direct sequencing of PCR products was adopted for genotyping. All three polymorphisms were found to be in Hardy–Weinberg equilibrium. Additive, dominant and recessive models were tested using multivariate regression analysis. The results of our study reveal a significant association between T1128C and hypertension even after adjusting for age, sex and BMI. The adjusted OR (95% confidence interval) for the recessive model was 0.56 (0.33–0.95). The other two polymorphic sites (G1258A and A7735G) are not associated with hypertension. The Pro7 allele of the T1128C polymorphic site-containing haplotype (CGA) is associated with hypertension (P=0.049), but the combined haplotypes did not show any evidence of haplotype–phenotype association (global P=0.129). These data support the hypothesis that hypertension is influenced by the NPY T1128C polymorphism.

Keywords:

neuropeptide Y; SNP; India

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