Abstract
People living in large informal settlements in South Africa showed a significant increase in cardio/cerebrovascular disease. This study was undertaken to compare the cardiovascular and endocrine parameters of urbanized and rural black female and males. The hormone levels such as prolactin, cortisol and testosterone may also change with urbanization and could make a contribution to the high rate of hypertension. For this study, 1202 black subjects were selected from 37 randomly selected rural and urbanized settlements. Resting blood pressure was recorded with a Finapres apparatus. Cardiac output, stroke volume, heart rate, total peripheral vascular resistance and compliance had been obtained with the Fast Modelflow software program. An acute laboratory stressor (hand dynamometer exercise) was applied to challenge the cardiovascular system and the measurements were repeated. Blood sampling was done and hormone levels were determined by biochemical analyses. For females, significant lower levels of cortisol were found in the urban strata in comparison with the rural strata. The testosterone levels were significantly lower and the prolactin levels significantly higher for females in the informal settlements compared with the rural strata. It is noticeable that most cardiovascular parameters showed the highest changes with the application of the stressor in the informal settlement strata and the lowest in people living on farms for both male and female. The prolactin levels in males are significantly higher in the informal settlement stratum. Subjects living in informal settlements showed a noticeable endocrine pattern of ongoing stress that can be associated with changes in the cardiovascular parameters with urbanization. This can partly explain the reported high rate of cardio/cerbrovascular disease in black South Africans living in informal settlements.
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References
Seedat YK . Hypertension in black South Africans J Hum Hypertens 1999 13: 97–103
Mollentze WF et al. Coronary heart disease risk factors in a rural and urban Orange Free State black population SA Med J 1995 85: 90–96
Giles WH et al. Prevalence of hypertension in rural West Africa Am J Med Sci 1994 308: 271–275
van Rooyen JM et al. An epidemiological study of hypertension and its determinants in a population in transition: the THUSA study J Hum Hypertens 2000 14: 779–787
Malan NT et al. A comparison of cardiovascular reactivity of rural blacks, urban blacks and whites Stress Med 1992 8: 241–246
Waldstein SR, Bachen AE, Manuck SB . Active coping and cardiovascular reactivity: a multiplicity of influences Psychosom Med 1997 59: 620–625
Anderson NB, McNeilly M, Myers H . Autonomic reactivity and hypertension in blacks: a review and proposed model Ethn Dis 1991 1: 154–170
Anderson NB et al. Assessment of cardiovascular reactivity: a methodological overview Ethn Dis 1993 3: (Suppl) S29–S37
Malan NT et al. A comparison of endocrine reactions to different types of acute stressors in rural and urban black populations Stress Med 1992 8: 213–218
Herd JA . Cardiovascular response to stress Physiol Rev 1991 17: 305–330
Obrist PA, Light KC, James SA, Strogatz DS . Cardiovascular responses to stress: 1. Measures of myocardial response and relationship to high resting systolic pressure and parental hypertension Psychophysiology 1987 24: 65–78
Light KC et al. Effects of race and marginally elevated blood pressure on response to stress Hypertension 1987 10: 555–563
Le Blanc J, Cote J, Jobin M, Labrie A . Plasma catecholamines and cardiovascular responses to cold and mental activity J Appl Physiol 1979 47: 1207–1211
Pretorius PJ et al. Gender and menstrual phase effects on cardiovascular reactivity during experimental stressors Arch Comp Environ Stud 1994 6: 37–49
Henry JP, Stephens PM, Ely DL . Psychosocial hypertension and the defence and defeat reactions J Hypertens 1986 4: 687–697
Brod J, Fencl V, Heji Z, Jirka J . Circulatory changes underlying blood pressure elevation during acute emotional stress (mental arithmetic) in normotensive and hypertensive subjects Clin Sci 1959 8: 269–279
Hilton SM . The defence-arousal system and its relevance for circulatory and respiratory control J Exp Biol 1982 100: 159–174
van Rooyen JM et al. Cardiovascular reactivity in black South African males of different age groups: the influence of urbanizaton Ethn Dis 2002 12: 69–75
Burton RF, Hinton JW, Nielson E, Beastall G . Concentrations of sodium, potassium and cortisol in saliva, and self-reported chronic work stress factors Biol Physiol 1996 42: 425–438
Gerra G et al. Neurotransmitter-hormonal responses to psychological stress in peripubertal subjects: relationship to aggressive behaviour Life Sci 1998 162: 617–625
Koszycki D et al. Behavioral, cardiovascular, and neuroendocrine profiles following ck-4 challenge in healthy volunteers: a comparison of panickers and nonpanickers Depression Anxiety 1998 8: 1–7
Heim C, Ehlert UM, Hellhammer DH . The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders Psychoneuroendocrinology 2000 25: 1–35
Kocijan-Hercigonja D et al. Psychological condition hormone levels in war trauma J Psychiatr Res 1996 30: 391–399
Gerra G et al. Neuroendocrine responses to psychological stress in adolescents with anxiety disorder Neuropsychobiology 2000 42: 82–92
Hellhammer DH, Wade S . Endocrine correlates of stress vulnerability Psychother Psychosom 1993 60: 8–17
McEwen BS . Protective and damaging effects of stress mediators N Engl J Med 1998 338: 171–179
Whitworth JA, Brown MA, Kelly JJ, Williamson PM . Mechanisms of cortisol-induced hypertension in humans Steroids 1995 60: 76–80
Kelly JJ et al. The nitric oxide system and cortisol-induced hypertension in humans Clin Exp Pharmacol 1998 25: 945–946
Kelly JJ, Williamson P, Martin A, Whitworth JA . Effects of oral L-arginine on plasma nitrate in blood pressure in cortisol-treated humans J Hypertens 2001 19: 263–268
Fraser R et al. Cortisol effects on body mass blood pressure, and cholesterol in the general population Hypertension 1999 33: 1364–1368
Arnetz BB, wiholm C . Technological stress: psychophysiological symptoms in modern offices J Psychosom Res 1997 43: 35–42
Westerlund H, Thoerell T, Bergström A . Psychophysiological effects of temporary alternative employment Soc Sci Med 2001 52: 405–415
Dickson RA, Glazer WM . Neuroleptic-induced hyperprolactinemia Schizophr Res 1999 35: S75–S86
Shaaraway M et al. Circulating nitric oxide levels in galactorrheic, hyperprolactinemic, amenorrheic women Fertil Steril 1997 68: 454–459
Elman I et al. Inverse relationship between plasma epinephrine and testosterone levels during acute glucoprivation in healthy men Life Sci 2001 68: 1889–1898
Gooren LJG . Endocrine aspects of ageing in the male Mol Cell Endocrinol 1998 145: 153–159
McCredie RJ et al. Vascular reactivity is impaired in genetic females taking high-dose androgens J Am Coll Cardiol 1998 32: 1331–1335
Mantzoros C et al. Relative androgenicity, blood pressure levels, and cardiovascular risk factors in young healthy women Am J Hypertens 1995 8: 606–614
Webb CM et al. Effects of testosterone on coronary vasomotor regulation in men with coronary heart disease Circulation 1999 100: 1690–1696
Rosano GMC et al. Acute anti-ischemic effect of testosterone in men with coronary artery disease Circulation 1999 99: 1666–1670
World Health Organization. International society of hypertension guidelines for the management of hypertension J Hypertens 1999 17: 151–183
Yach D, Mathews C, Buch E . Urbanization and health: methodological difficulties in undertaking epidemiological research in developing countries Soc Sci Med 1990 31: 507–514
Wesseling KH, Settels JJ, de Wit B . The measurement of continuous finger arterial pressure non-invasively in stationary subjects. In: Schmidt TH, Dembroski TM, Blümchen G (eds) Biological Factors in Cardiovascular Disease Springer: Berlin 1986 pp 355–375
Harms MPM et al. Continuous stroke volume monitoring by modelling flow from non-invasively measurement of arterial pressure in humans under orthostatic stress Clin Sci 1999 97: 291–301
Wesseling KH, Jansen JRC, Settels JJ, Schreuder JJ . Computation of aortic flow from pressure in humans using a non-linear, three-element model J Appl Physiol 1993 74: 2566–2573
Idahosa PE . Hypertension: an ongoing health hazard in Nigerian workers Am J Epidemiol 1987 125: 85–91
Bunker CH et al. Factors associated with hypertension in Nigerian civil servants Prev Med 1992 21: 710–722
Kaufman JS et al. Determinants of hypertension in West Africa: contribution of anthropometic and deitary factors to urban–rural and socio-economic gradients Am J Epidemiol 1996 143: 1203–1218
SarrafZadegan N, AminiNik S . Blood pressure pattern in urban and rural areas in Isfahan, Iran J Hum Hypertens 1997 11: 425–428
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Huisman, H., van Rooyen, J., Malan, N. et al. Prolactin, testosterone and cortisol as possible markers of changes in cardiovascular function associated with urbanization. J Hum Hypertens 16, 829–835 (2002). https://doi.org/10.1038/sj.jhh.1001493
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DOI: https://doi.org/10.1038/sj.jhh.1001493
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