Brief Report - Polymorphism Report

Journal of Human Genetics (1999) 44, 416–418; doi:10.1007/s100380050191

Novel polymorphisms in the upstream region of the human dopamine D4 receptor (DRD4) gene

Hiroshi Mitsuyasu, Hidetoshi Ozawa, Yasuhiko Takeda and Yasuyuki Fukumaki

Division of Disease Genes , Institute of Genetic Information, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan

Correspondence: Yasuyuki Fukumaki, Division of Disease Genes , Institute of Genetic Information, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Fax: +81-92-632-2375. E-mail: yfukumak@gen.kyushu-u.ac.jp

Received 11 June 1999; Accepted 23 June 1999.

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Abstract

We found nine novel polymorphisms in the upstream region of the human dopamine D4 receptor (DRD4) gene of Japanese by direct sequencing. These polymorphisms are -809G > A, -768G > A, -616C > G, -603T > del, -602G > del, -600G > C, -376C > T, -291C > T, and -128G > T. One known polymorphism, -521C > T, was also recognized. Six of these sites were identified as restriction fragment length polymorphisms (RFLPs).

Keywords:

Dopamine D4 receptor gene, Promoter, Polymorphisms, RFLP