Short Communication
Journal of Human Genetics (1998) 43, 132–134; doi:10.1007/s100380050054
Genomic organization and mapping of the human activin receptor type IIB (hActR-IIB) gene
Shinji Ishikawa1,2, Mikio Kai1, Yasushi Murata1, Mayumi Tamari1, Yataro Daigo1, Takeshi Murano1, Michio Ogawa2 and Yusuke Nakamura1,3
- 1Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
- 2Department of Surgery II, Kumamoto University Medical School, Kumamoto, Japan
- 3Department of Genome Analysis, Cancer Institute, Tokyo, Japan
Correspondence: Yusuke Nakamura, Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. Fax: +81-3-5449-5433. E-mail: yusuke@ims.u-tokyo.ac.jp
Received 11 August 1997; Accepted 22 October 1997.
Abstract
Activins, members of a family of proteins that includes transforming growth factor-beta (TGF-beta), are gonadal polypeptide hormones that stimulate secretion of follicle-stimulating hormone (FSH). During large-scale sequencing analysis of a 1.2-Mb fragment of human genomic DNA on 3p22–p21.3, we found the gene encoding activin receptor type IIB (hActR-IIB). Comparison of its reported cDNA sequence with this genomic sequence showed that the hActR-IIB gene consists of 11 exons and spans about 30 kb of genomic DNA.
Keywords:
Genomic structure, Activin receptor, Large-scale DNA sequencing
