Abstract
The association between O3 exposure and preterm birth (PTB) remains unclear. We evaluated associations for three categories of PTB and O3 in Harris County, Texas, during narrow periods of gestation. We computed two sets of exposure metrics during every 4 weeks of pregnancy for 152,214 mothers who delivered singleton, live-born infants in 2005–2007, accounting first for temporal variability and then for temporal and spatial sources of variability in ambient O3 levels. Associations were assessed using multiple logistic regression. We also examined the potential for a fixed cohort bias. In the bias-corrected cohort where associations were somewhat stronger, elevated odds ratios (ORs) per 10 parts per billion increase in O3 exposure (county-level metric) were detected for the fifth (OR=1.08, 95% confidence interval (CI): 1.04–1.12), sixth (OR=1.05, 95% CI=1.01–1.09), and seventh (OR=1.07, 95% CI=1.03–1.10) 4-week periods of pregnancy for late PTB (33–36 completed weeks gestation), the fifth (OR=1.13, 95% CI=1.02–1.25) and seventh (OR=1.15, 95% CI=1.04–1.27) 4-week periods of pregnancy for moderate PTB (29–32 completed weeks gestation), and the fifth (OR=1.21, 95% CI=1.08–1.36) 4-week period of pregnancy for severe PTB (20–28 completed weeks gestation). Conversely, decreased odds were found in the first 4-week period of pregnancy for severe PTB (OR=0.83, 95% CI=0.74–0.94). Associations were slightly attenuated using the spatially interpolated (kriged) metrics, and for women who did not work outside of the home. Our analyses confirm reports in other parts of the United States and elsewhere with findings that suggest that maternal exposure to ambient levels of O3 is associated with PTB.
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References
Texas Commission on Environmental Quality (TCEQ). Agency Activities: Air Quality (FY2011-2012). 2013; http://www.tceq.texas.gov/publications/sfr/057_12/air. Accessed on 6 September 2013.
Texas Commission on Environmental Quality (TCEQ). Ozone: The Facts. 2013; http://www.tceq.state.tx.us/airquality/monops/ozonefacts.html. Accessed 6 September 2013.
U.S. Department of Transportation, Bureau of Transportation Statistics. Texas Transportation Profile. 2002; http://www.rita.dot.gov/bts/sites/rita.dot.gov.bts/files/publications/state_transportation_statistics/texas/pdf/entire.pdf. Accessed on 17 April 2011.
City of Houston. Houston Facts and Figures. 2013; http://www.houstontx.gov/abouthouston/houstonfacgts.html. Accessed on 6 September 2013.
Greater Houston Partnership. Houston: Energy Powerhouse. 2013; http://www.houston.org/assets/pdf/opportunity/Energy-Data-Sheet.pdf. Accessed on 6 September 2013.
Shah PS, Balkhair T . Air pollution and birth outcomes: A systematic review. Environ Int 2011; 37: 498–516.
Stieb DM, Chen L, Eshoul M, Judek S . Ambient air pollution, birth weight and preterm birth: A systematic review and meta-analysis. Environ Res 2012; 117: 100–111.
Wu J, Wilhelm M, Chung J, Ritz B . Comparing exposure assessment methods for traffic-related air pollution in an adverse pregnancy outcome study. Environ Res 2011; 111: 685–692.
Schifano P, Lallo A, Asta F, De Sario M, Davoli M, Michelozzi P . Effect of ambient temperature and air pollutants on the risk of preterm birth, Rome 2001-2010. Environ Int 2013; 61: 77–87.
Ritz B, Yu F, Chapa G, Fruin S . Effect of air pollution on preterm birth among children born in Southern California between 1989 and 1993. Epidemiology 2000; 11: 502–511.
Ritz B, Wilhelm M, Hoggatt KJ, Ghosh JK . Ambient air pollution and preterm birth in the environment and pregnancy outcomes study at the University of California, Los Angeles. Am J Epidemiol 2007; 166: 1045–1052.
Liu S, Krewski D, Shi Y, Chen Y, Burnett RT . Association between gaseous ambient air pollutants and adverse pregnancy outcomes in Vancouver, Canada. Environ Health Perspect 2003; 111: 1773–1778.
Wilhelm M, Ritz B . Local variations in CO and particulate air pollution and adverse birth outcomes in Los Angeles County, California, USA. Environ Health Perspect 2005; 113: 1212–1221.
Le HQ, Batterman SA, Wirth JJ, Wahl RL, Hoggatt KJ, Sadeghnejad A et al. Air pollutant exposure and preterm and term small-for-gestational-age births in Detroit, Michigan: Long-term trends and associations. Environ Int 2012; 44: 7–17.
Lee PC, Roberts JM, Catov JM, Talbott EO, Ritz B . First trimester exposure to ambient air pollution, pregnancy complications and adverse birth outcomes in Allegheny County, PA. Matern Child Hlth J. 2013; 17: 545–555.
Hansen C, Neller A, Williams G, Simpson R . Maternal exposure to low levels of ambient air pollution and preterm birth in Brisbane, Australia. BJOG 2006; 113: 935–941.
Ha S, Hu H, Roussos-Ross D, Haidong K, Roth J, Xu X . The effects of air pollution on adverse birth outcomes. Environ Res 2014; 134C: 198–204.
Gray SC, Edwards SE, Schultz BD, Miranda ML . Assessing the impact of race, social factors and air pollution on birth outcomes: A population-based study. Environ Health 2014; 13: 4.
Olsson D, Ekstrom M, Forsberg B . Temporal variation in air pollution concentrations and preterm birth-a population based epidemiological study. Int J Environ Res Public Health 2012; 9: 272–285.
Olsson D, Mogren I, Forsberg B . Air pollution exposure in early pregnancy and adverse pregnancy outcomes: A register-based cohort study. BMJ Open 2013; 3: e001955.
Jalaludin B, Mannes T, Morgan G, Lincoln D, Sheppeard V, Corbett S . Impact of ambient air pollution on gestational age is modified by season in Sydney, Australia. Environ Health 2007; 6: 16.
Dadvand P, Parker J, Bell ML, Bonzini M, Brauer M, Darrow LA et al. Maternal exposure to particulate air pollution and term birth weight: A multi-country evaluation of effect and heterogeneity. Environ Health Perspect 2013; 121: 267–373.
Woodruff TJ, Parker JD, Adams K, Bell ML, Gehring U, Glinianaia S et al. International Collaboration on Air Pollution and Pregnancy Outcomes (ICAPPO). Int J Environ Res Public Health 2010; 7: 2638–2652.
Symanski E, Davila M, McHugh MK, Waller DK, Zhang X, Lai D . Maternal exposure to fine particulate air pollution during narrow gestational periods and newborn health in Harris County, Texas. Matern Child Hlth J 2014; 18: 2003–2012.
Jerrett M, Burnett RT, Ma R, Pope CA, 3rd, Krewski D, Newbold KB et al. Spatial analysis of air pollution and mortality in Los Angeles. Epidemiology 2005; 16: 727–736.
Liao D, Peuquet DJ, Duan Y, Whitsel EA, Dou J, Smith RL et al. GIS approaches for the estimation of residential-level ambient PM concentrations. Environ Health Perspect 2006; 114: 1374–1380.
Leem JH, Kaplan BM, Shim YK, Pohl HR, Gotway CA, Bullard SM et al. Exposures to air pollutants during pregnancy and preterm delivery. Environ Health Perspect 2006; 114: 905–910.
Strand LB, Barnett AG, Tong S . Methodological challenges when estimating the effects of season and seasonal exposures on birth outcomes. BMC Med Res Methodol 2011; 11: 49.
Lin YT, Lee YL, Jung CR, Jaakkola JJ, Hwang BF . Air pollution and limb defects: A matched-pairs case-control study in Taiwan. Environ Res 2014; 132: 273–280.
Hansen CA, Barnett AG, Jalaludin BB, Morgan GG . Ambient air pollution and birth defects in Brisbane, Australia. PLoS One 2009; 4: e5408.
Vrijheid M, Martinez D, Manzanares S, Dadvand P, Schembari A, Rankin J et al. Ambient air pollution and risk of congenital anomalies: A systematic review and meta-analysis. Environ Health Perspect 2011; 119: 598–606.
Honein MA, Kirby RS, Meyer RE, Xing J, Skerrette NI, Yuskiv N et al. The association between major birth defects and preterm birth. Matern Child Hlth J 2009; 13: 164–175.
Grandi C, Luchtenberg G, Rittler M . The contribution of birth defects to spontaneous preterm birth. Am J Perinat 2007; 24: 487–492.
Shaw GM, Savitz DA, Nelson V, Thorp JM, Jr . Role of structural birth defects in preterm delivery. Paediatr Perinat Ep 2001; 15: 106–109.
U.S. Environmental Protection Agency (EPA). Air Quality System (AQS) Data Mart. 2009; http://www.epa.gov/ttn/airs/aqsdatamart/. Accessed on 28 May 2009.
Waller L . Applied Spatial Statistics for Public Health Data. John Wiley & Sons: Hoboken, NJ. 2004.
U.S. Centers for Disease Control and Prevention (CDC). About BMI for Adults. 2011; http://www.cdc.gov/healthyweight/assessing/bmi/adult_bmi/index.html (Accessed 22 March 2011).
Rothman KJ, Greenland S, Lash TL . Modern Epidemiology. Third edn. Lippincott Williams & Wilkins: Philadelphia. 2008.
Institute of Medicine of the National Academies (IOM) Preterm Birth: Causes, Consequences, and Prevention. Behrman RE, Stith Butler A (eds). The National Academies Press: Washington, D.C.. 2007.
U.S. Centers for Disease Control and Prevention (CDC). Preterm Birth. 2014; http://www.cdc.gov/reproductivehealth/maternalinfanthealth/pretermbirth.htm.Accessed on 29 January 2015.
U.S. Environmental Protection Agency (EPA). Currently Designated Nonattainment Areas for all Criteria Pollutants. 2013; http://www.epa/gov/oaqps001/greenbk/ancl.html. Accessed on 12 February 2014.
Institute of Medicine of the National Academies (IOM). Biological pathways leading to preterm birth. Preterm Birth: Causes, Consequences, and Prevention. The National Academies Press: Washington, D.C.. 2007.
Kannan S, Misra DP, Dvonch JT, Krishnakumar A . Exposures to airborne particulate matter and adverse perinatal outcomes: A biologically plausible mechanistic framework for exploring potential effect modification by nutrition. Environ Health Perspect 2006; 114: 1636–1642.
Slama R, Morgenstern V, Cyrys J, Zutavern A, Herbarth O, Wichmann HE et al. Traffic-related atmospheric pollutants levels during pregnancy and offspring's term birth weight: A study relying on a land-use regression exposure model. Environ Health Perspect 2007; 115: 1283–1292.
Rappazzo KM, Daniels JL, Messer LC, Poole C, Lobdell DT . Exposure to fine particulate matter during pregnancy and risk of reterm birth among women in New Jersey, Ohio, and Pennsylvania, 2000-2005. Environ Health Perspect 2014; 122: 992–997.
Warren JL, Fuentes M, Herring AH, Langlois PH . Air pollution metric analysis while determining susceptible periods of pregnancy for low birth weight. ISRN Obstet Gynecol 2013; 2013: 387452.
Hwang BF, Lee YL, Jaakkola JJ . Time-dependent exposures and the fixed-cohort bias: Hwang et al. respond. Environ Health Perspect. 2011; 119: a423–a423.
Lupo P, Symanski E, Chan W, Mitchell L, Canfield M, Langlois P . Differences in exposure assignment between conception and delivery: The impact of maternal mobility. Paediatr Perinat Ep 2010; 24: 200–208.
Chen L, Bell EM, Caton AR, Druschel CM, Lin S . Residential mobility during pregnancy and the potential for ambient air pollution exposure misclassification. Environ Res 2010; 110: 162–168.
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This study was supported by grant number 5R21ES017347 from the National Institute of Environmental Health Sciences.
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Symanski, E., McHugh, M., Zhang, X. et al. Evaluating narrow windows of maternal exposure to ozone and preterm birth in a large urban area in Southeast Texas. J Expo Sci Environ Epidemiol 26, 167–172 (2016). https://doi.org/10.1038/jes.2015.32
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DOI: https://doi.org/10.1038/jes.2015.32
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