Web Focus
Cerebral Investigations: MRI & PET imaging
- Since their introduction to medicine, Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) have greatly contributed to medical research and clinical practice. In particular, brain imaging with MRI and PET scans has led to important insights into both the normal and diseased brain. With increasingly advanced technology, scanning techniques, and clinical applications, brain imaging is a continuously evolving field. This web focus, presented by the Journal of Cerebral Blood Flow & Metabolism, compiles many of the most important research papers on the techniques and applications of cerebral MRI and PET imaging.
Image: Anatomical SPGR MR images (left) and Pittsburgh Compound-B PET SUV images (right) of amyloid binding, from article by JC Price et al.
: 2006
18FDG PET in vascular dementia: differentiation from Alzheimer's disease using voxel-based multivariate analysis FREE
Nacer Kerrouche, Karl Herholz, Rüdiger Mielke, Vjera Holthoff and Jean-Claude Baron
J Cereb Blood Flow Metab 26: 1213-1221; advance online publication, March 8, 2006; doi:10.1038/sj.jcbfm.9600296
Heterogeneous oxygen extraction in the visual cortex during activation in mild hypoxic hypoxia revealed by quantitative functional magnetic resonance imaging FREE
Pasi I Tuunanen, Ian J Murray, Neil R A Parry and Risto A Kauppinen
J Cereb Blood Flow Metab 26: 263-273; advance online publication, August 3, 2005; doi:10.1038/sj.jcbfm.9600186
Intersubject variability and reproducibility of 15O PET studies FREE
Jonathan P Coles, Tim D Fryer, Peter G Bradley, Jurgens Nortje, Peter Smielewski, Kenneth Rice, John C Clark, John D Pickard and David K Menon
J Cereb Blood Flow Metab 26: 48-57; advance online publication, June 29, 2005; doi:10.1038/sj.jcbfm.9600179
Model selection in magnetic resonance imaging measurements of vascular permeability: Gadomer in a 9L model of rat cerebral tumor FREE
James R Ewing, Stephen L Brown, Mei Lu, Swayamprava Panda, Guangliang Ding, Robert A Knight, Yue Cao, Quan Jiang, Tavarekere N Nagaraja, Jamie L Churchman and Joseph D Fenstermacher
J Cereb Blood Flow Metab 26: 310-320; advance online publication, August 3, 2005; doi:10.1038/sj.jcbfm.9600189
Parkinson's disease and brain mitochondrial dysfunction: a functional phosphorus magnetic resonance spectroscopy study FREE
Mario Rango, Cristiana Bonifati and Nereo Bresolin
J Cereb Blood Flow Metab 26: 283-290; advance online publication, August 10, 2005; 10.1038/sj.jcbfm.9600192
Present status of Magnetic resonance imaging and spectroscopy in animal stroke models FREE
Ralph Weber, Pedro Ramos-Cabrer and Mathias Hoehn
J Cereb Blood Flow Metab 26: 591-604; advance online publication, November 16, 2005; 10.1038/sj.jcbfm.9600241
Quantitative evaluation of cerebral hemodynamics in patients with moyamoya disease by dynamic susceptibility contrast magnetic resonance imaging - comparison with positron emission tomography FREE
Yoji Tanaka, Tadashi Nariai, Tsukasa Nagaoka, Hideaki Akimoto, Kiichi Ishiwata, Kenji Ishii, Yoshiharu Matsushima and Kikuo Ohno
J Cereb Blood Flow Metab 26: 291-300; advance online publication, July 27, 2005; 10.1038/sj.jcbfm.9600187
Temporal profile of T2-weighted MRI distinguishes between pannecrosis and selective neuronal death after transient focal cerebral ischemia in the rat FREE
Susanne Wegener, Ralph Weber, Pedro Ramos-Cabrer, Ulla Uhlenkueken, Christiane Sprenger, Dirk Wiedermann, Arno Villringer and Mathias Hoehn
J Cereb Blood Flow Metab 26: 38-47; advance online publication, June 29, 2005; 10.1038/sj.jcbfm.9600166
The spatial dependence of the poststimulus undershoot as revealed by high-resolution BOLD- and CBV-weighted fMRI FREE
Essa Yacoub, Kamil Ugurbil and Noam Harel
J Cereb Blood Flow Metab 26: 634-644; advance online publication, October 12, 2005; 10.1038/sj.jcbfm.9600239
: 2005
Top of pageChanges in cerebral blood flow and cerebral oxygen metabolism during neural activation measured by positron emission tomography: comparison with blood oxygenation level-dependent contrast measured by functional magnetic resonance imaging FREE
Hiroshi Ito, Masanobu Ibaraki, Iwao Kanno, Hiroshi Fukuda and Shuichi Miura
J Cereb Blood Flow Metab 25: 371-377; advance online publication, January 19, 2005; doi:10.1038/sj.jcbfm.9600030
Changes in the arterial fraction of human cerebral blood volume during hypercapnia and hypocapnia measured by positron emission tomography FREE
Hiroshi Ito, Masanobu Ibaraki, Iwao Kanno, Hiroshi Fukuda and Shuichi Miura
J Cereb Blood Flow Metab 25: 852-857; advance online publication, February 16, 2005; doi:10.1038/sj.jcbfm.9600076
Characterization of the effects of adenosine receptor agonists on cerebral blood flow in uninjured and traumatically injured rat brain using continuous arterial spin-labeled magnetic resonance imaging FREE
Patrick M Kochanek, Kristy S Hendrich, Edwin K Jackson, Stephen R Wisniewski, John A Melick, Paul M Shore, Keri L Janesko, Lefteris Zacharia and Chien Ho
J Cereb Blood Flow Metab 25: 1596-1612; advance online publication, June 1, 2005; doi:10.1038/sj.jcbfm.9600154
Crossed cerebellar diaschisis in acute human stroke: a PET study of serial changes and response to supratentorial reperfusion FREE
Jan Sobesky, Alexander Thiel, Mehran Ghaemi, Rüdiger H Hilker, Jobst Rudolf, Andreas H Jacobs, Karl Herholz and Wolf-Dieter Heiss
J Cereb Blood Flow Metab 25: 1685-1691; advance online publication, June 1, 2005; doi:10.1038/sj.jcbfm.9600162
Glycolysis versus TCA cycle in the primate brain as measured by combining 18F-FDG PET and 13C-NMR FREE
Fawzi Boumezbeur, Laurent Besret, Julien Valette, Marie-Claude Gregoire, Thierry Delzescaux, Renaud Maroy, Françoise Vaufrey, Philippe Gervais, Philippe Hantraye, Gilles Bloch and Vincent Lebon
J Cereb Blood Flow Metab 25: 1418-1423; advance online publication, May 25, 2005; doi:10.1038/sj.jcbfm.9600145
High-resolution blood-brain barrier permeability and blood volume imaging using quantitative synchrotron radiation computed tomography: study on an F98 rat brain glioma FREE
Jean-Francois Adam, Christian Nemoz, Alberto Bravin, Stefan Fiedler, Sam Bayat, Sylvie Monfraix, Gilles Berruyer, Anne Marie Charvet, Jean-François Le Bas, Hélène Elleaume and Francois Estéve
J Cereb Blood Flow Metab 25: 145-153; doi:10.1038/sj.jcbfm.9600017
Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B FREE
Julie C Price, William E Klunk, Brian J Lopresti, Xueling Lu, Jessica A Hoge, Scott K Ziolko, Daniel P Holt, Carolyn C Meltzer, Steven T DeKosky and Chester A Mathis
J Cereb Blood Flow Metab 25: 1528-1547; advance online publication, June 8, 2005; doi:10.1038/sj.jcbfm.9600146
Measurement of regional rates of cerebral protein synthesis with L-[1-11C]leucine and PET with correction for recycling of tissue amino acids: I. Kinetic modeling approach FREE
Kathleen C Schmidt, Michelle P Cook, Mei Qin, Julia Kang, Thomas V Burlin and Carolyn Beebe Smith
J Cereb Blood Flow Metab 25: 617-628; advance online publication, February 9, 2005; doi:10.1038/sj.jcbfm.9600067
Measurement of regional rates of cerebral protein synthesis with L-[1-11C]leucine and PET with correction for recycling of tissue amino acids: II. Validation in rhesus monkeys FREE
Carolyn Beebe Smith, Kathleen C Schmidt, Mei Qin, Thomas V Burlin, Michelle P Cook, Julia Kang, Richard C Saunders, John D Bacher, Richard E Carson, Michael A Channing, William C Eckelman, Peter Herscovitch, Peter Laverman and Bik-Kee Vuong
J Cereb Blood Flow Metab 25: 629-640; advance online publication, February 9, 2005; doi:10.1038/sj.jcbfm.9600066
Measurements of BOLD/CBV ratio show altered fMRI hemodynamics during stroke recovery in rats FREE
Young R Kim, In J Huang, Seong-Ryong Lee, Emiri Tejima, Joseph B Mandeville, Maurits P A van Meer, George Dai, Yong W Choi, Rick M Dijkhuizen, Eng H Lo and Bruce R Rosen
J Cereb Blood Flow Metab 25: 820-829; advance online publication, March 9, 2005; doi:10.1038/sj.jcbfm.9600084
Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study FREE
Paul Vespa, Marvin Bergsneider, Nayoa Hattori, Hsiao-Ming Wu, Sung-Cheng Huang, Neil A Martin, Thomas C Glenn, David L McArthur and David A Hovda
J Cereb Blood Flow Metab 25: 763-774; advance online publication, February 16, 2005; doi:10.1038/sj.jcbfm.9600073
Quantitative evaluation of BBB permeability after embolic stroke in rat using MRI FREE
Quan Jiang, James R Ewing, Guang Liang Ding, Li Zhang, Zheng Gang Zhang, Lian Li, Polly Whitton, Mei Lu, Jiani Hu, Qing Jiang Li, Robert A Knight and Michael Chopp
J Cereb Blood Flow Metab 25: 583-592; advance online publication, February 16, 2005; doi:10.1038/sj.jcbfm.9600053
Regional heterogeneity of 5-HT1A receptors in human cerebellum as assessed by positron emission tomography FREE
Ramin V Parsey, Victoria Arango, Doreen M Olvet, Maria A Oquendo, Ronald L Van Heertum and J John Mann
J Cereb Blood Flow Metab 25: 785-793; advance online publication, February 16, 2005; doi:10.1038/sj.jcbfm.9600072
The astrocyte-neuron lactate shuttle: a debated but still valuable hypothesis for brain imaging FREE
Gilles Bonvento, Anne-Sophie Herard and Brigitte Voutsinos-Porche
J Cereb Blood Flow Metab 25: 1394-1399; advance online publication, April 20, 2005; doi:10.1038/sj.jcbfm.9600127
: Nature Medicine
Top of pageA new transgene reporter for in vivo magnetic resonance imaging FREE
Guillem Genove, Ulrike DeMarco, Hongyan Xu, William F Goins and Eric T Ahrens
Nature Medicine 11: 450-454; advance online publication, March 20, 2005; doi:10.1038/nm1208
: NCP Neurology
Top of pageCan acute MRI predict outcome following transient ischemic attack and minor stroke? FREE
Jeffrey L Saver
Nature Clinical Practice Neurology 2: 14-15; doi:10.1038/ncpneuro0049
Technology Insight: imaging amyloid plaques in the living brain with positron emission tomography and MRI FREE
Dan E Huddleston and Scott A Small
Nature Clinical Practice Neurology 1: 96-105; doi:10.1038/ncpneuro0046
: Nature Neuroscience
Top of page19F and 1H MRI detection of amyloid Β plaques in vivo FREE
Makoto Higuchi, Nobuhisa Iwata, Yukio Matsuba, Kumi Sato, Kazumi Sasamoto and Takaomi C Saido
Nature Neuroscience 8: 527-533; advance online publication, March 13, 2005; doi:10.1038/nn1422
PET imaging of dopamine D2 receptors during chronic cocaine self-administration in monkeys FREE
Michael A Nader, Drake Morgan, H Donald Gage, Susan H Nader, Tonya L Calhoun, Nancy Buchheimer, Richard Ehrenkaufer and Robert H Mach
Nature Neuroscience 9: 1050-1056; advance online publication, July 9, 2006; doi:10.1038/nn1737
