Web Focus
Genes in Ischemia
- The interruption of blood flow to any part of the brain can have devastating effects. Indeed, brain ischemia is a leading cause of death and disability in the aged population. The complex nature of ischemic injury has complicated the search for effective prevention and treatment. Recent advances in the study of genomics have lead to promising leads in the research of ischemic prevention, diagnosis and treatment. This special web focus by the Journal of Cerebral Blood Flow & Metabolism presents many of the most important recent articles in this quickly developing field.
Image: Ischemic damage in the hippocampus, from article by J Kofler et al.
: 2006
Gene expression in blood changes rapidly in neutrophils and monocytes after ischemic stroke in humans: a microarray study FREE
Yang Tang, Huichun Xu, XinLi Du, Lisa Lit, Wynn Walker, Aigang Lu, Ruiqiong Ran, Jeffrey P Gregg, Melinda Reilly, Art Pancioli, Jane C Khoury, Laura R Sauerbeck, Janice A Carrozzella, Judith Spilker, Joseph Clark, Kenneth R Wagner, Edward C Jauch, Dongwoo J Chang, Piero Verro, Joseph P Broderick and Frank R Sharp
J Cereb Blood Flow Metab 26: 1089-1102; advance online publication, January 4, 2006; doi:10.1038/sj.jcbfm.9600264
Novel therapeutic strategy for stroke in rats by bone marrow stromal cells and ex vivo HGF gene transfer with HSV-1 vector FREE
Ming-Zhu Zhao, Naosuke Nonoguchi, Naokado Ikeda, Takuji Watanabe, Daisuke Furutama, Daisuke Miyazawa, Hiroshi Funakoshi, Yoshinaga Kajimoto, Toshikazu Nakamura, Mari Dezawa, Masa-Aki Shibata, Yoshinori Otsuki, Robert S Coffin, Wei-Dong Liu, Toshihiko Kuroiwa and Shin-Ichi Miyatake
J Cereb Blood Flow Metab 26: 1176-1188; advance online publication, January 18, 2006; doi:10.1038/sj.jcbfm.9600273
Bench to bedside: the quest for quality in experimental stroke research FREE
Ulrich Dirnagl
J Cereb Blood Flow Metab 26: 1465-1478; advance online publication, March 8, 2006; doi:10.1038/sj.jcbfm.9600298
Differential effect of PARP-2 deletion on brain injury after focal and global cerebral ischemia FREE
Julia Kofler, Takashi Otsuka, Zhizheng Zhang, Ruediger Noppens, Marjorie R Grafe, David W Koh, Valina L Dawson, Josiane Ménissier de Murcia, Patricia D Hurn and Richard J Traystman
J Cereb Blood Flow Metab 26: 135-141; advance online publication, June 15, 2005; doi:10.1038/sj.jcbfm.9600173
Inducible nitric oxide synthase contributes to gender differences in ischemic brain injury FREE
Eun-Mi Park, Sunghee Cho, Kelly A Frys, Sara B Glickstein, Ping Zhou, Josef Anrather, Margaret E Ross and Costantino Iadecola
J Cereb Blood Flow Metab 26: 392-401; advance online publication, July 27, 2005; 10.1038/sj.jcbfm.9600194
Prevention of apoptosis-inducing factor translocation is a possible mechanism for protective effects of hepatocyte growth factor against neuronal cell death in the hippocampus after transient forebrain ischemia FREE
Makiko Niimura, Norio Takagi, Keiko Takagi, Reiko Mizutani, Naoko Ishihara, Kunio Matsumoto, Hiroshi Funakoshi, Toshikazu Nakamura and Satoshi Takeo
J Cereb Blood Flow Metab 26: 1354-1365; advance online publication, March 1, 2006; 10.1038/sj.jcbfm.9600287
P2X7 receptor modulation on microglial cells and reduction of brain infarct caused by middle cerebral artery occlusion in rat FREE
Alessia Melani, Susanna Amadio, Marco Gianfriddo, Maria G Vannucchi, Cinzia Volontè, Giorgio Bernardi, Felicita Pedata and Giuseppe Sancesario
J Cereb Blood Flow Metab 26: 974-982; advance online publication, January 4, 2006; 10.1038/sj.jcbfm.9600250
: 2005
Top of pageIschemic nitric oxide and poly (ADP-ribose) polymerase-1 in cerebral ischemia: male toxicity, female protection FREE
Louise D McCullough, Zhiyuan Zeng, Kathleen K Blizzard, Indira Debchoudhury and Patricia D Hurn
J Cereb Blood Flow Metab 25: 502-512; advance online publication, February 2, 2005; doi:10.1038/sj.jcbfm.9600059
Neuronal activation of NF-kappa B contributes to cell death in cerebral ischemia FREE
Wen Zhang, Ioana Potrovita, Victoria Tarabin, Oliver Herrmann, Verena Beer, Falk Weih, Armin Schneider and Markus Schwaninger
J Cereb Blood Flow Metab 25: 30-40; doi:10.1038/sj.jcbfm.9600004
Hsp70 overexpression sequesters AIF and reduces neonatal hypoxic/ischemic brain injury FREE
Yasuhiko Matsumori, Shwuhuey M Hong, Koji Aoyama, Yang Fan, Takamasa Kayama, R Ann Sheldon, Zinaida S Vexler, Donna M Ferriero, Philip R Weinstein and Jialing Liu
J Cereb Blood Flow Metab 25: 899-910; advance online publication, March 2, 2005; doi:10.1038/sj.jcbfm.9600080
CREB-mediated Bcl-2 protein expression after ischemic preconditioning FREE
Robert Meller, Manabu Minami, Jennifer A Cameron, Soren Impey, Dexi Chen, Jing-Quan Lan, David C Henshall and Roger P Simon
J Cereb Blood Flow Metab 25: 234-246; advance online publication, January 5, 2005; doi:10.1038/sj.jcbfm.9600024
Monocyte chemoattractant protein-1 regulation of blood-brain barrier permeability FREE
Svetlana M Stamatovic, Parvin Shakui, Richard F Keep, Bethany B Moore, Steven L Kunkel, Nico Van Rooijen and Anuska V Andjelkovic
J Cereb Blood Flow Metab 25: 593-606; advance online publication, February 2, 2005; doi:10.1038/sj.jcbfm.9600055
Obligatory role of inducible nitric oxide synthase in ischemic preconditioning FREE
Sunghee Cho, Eun-Mi Park, Ping Zhou, Kelly Frys, M Elizabeth Ross and Costantino Iadecola
J Cereb Blood Flow Metab 25: 493-501; advance online publication, February 2, 2005; doi:10.1038/sj.jcbfm.9600058
Minocycline protects against permanent cerebral ischemia in wild type but not in matrix metalloprotease-9-deficient mice FREE
Milla Koistinaho, Tarja M Malm, Mikko I Kettunen, Gundars Goldsteins, Sofie Starckx, Risto A Kauppinen, Ghislain Opdenakker and Jari Koistinaho
J Cereb Blood Flow Metab 25: 460-467; advance online publication, January 26, 2005; doi:10.1038/sj.jcbfm.9600040
Doxycycline reduces cleaved caspase-3 and microglial activation in an animal model of neonatal hypoxia-ischemia FREE
Lauren L Jantzie, Po-Yin Cheung and Kathryn G Todd
J Cereb Blood Flow Metab 25: 314-324; advance online publication, January 12, 2005; doi:10.1038/sj.jcbfm.9600025
Release of bradykinin and expression of kinin B-2 receptors in the brain: role for cell death and brain edema formation after focal cerebral ischemia in mice FREE
Moritz Gröger, Diane Lebesgue, Didier Pruneau, Jane Relton, Seong-Woong Kim, Jürg Nussberger and Nikolaus Plesnila
J Cereb Blood Flow Metab 25: 978-989; advance online publication, April 6, 2005; doi:10.1038/sj.jcbfm.9600096
Protective effects of statin involving both eNOS and tPA in focal cerebral ischemia FREE
Minoru Asahi, Zhihong Huang, Sunu Thomas, Shin-ichi Yoshimura, Toshihisa Sumii, Tatsuro Mori, Jianhua Qiu, Sepideh Amin-Hanjani, Paul L Huang, James K Liao, Eng H Lo and Michael A Moskowitz
J Cereb Blood Flow Metab 25: 722-729; advance online publication, February 16, 2005; doi:10.1038/sj.jcbfm.9600070
: Nature Reviews Neuroscience
Top of pageCerebral preconditioning and ischaemic tolerance FREE
Jeffrey M. Gidday
Nature Reviews Neuroscience 7: 437-448; doi:10.1038/nrn1927
: Nature Medicine
Top of pageNewly expressed SUR1-regulated NCCa-ATP channel mediates cerebral edema after ischemic stroke
J Marc Simard, Mingkui Chen, Kirill V Tarasov, Sergei Bhatta, Svetlana Ivanova, Ludmila Melnitchenko, Natalya Tsymbalyuk, G Alexander West and Volodymyr Gerzanich
Nature Medicine 12: 433-440; advance online publication, March 19, 2006; doi:10.1038/nm1390
IKK mediates ischemia-induced neuronal death
Oliver Herrmann, Bernd Baumann, Rossana de Lorenzi, Sajjad Muhammad, Wen Zhang, Jens Kleesiek, Max Malfertheiner, Martin Köhrmann, Ioana Potrovita, Ira Maegele, Cordian Beyer, James R Burke, Mazahir T Hasan, Hermann Bujard, Thomas Wirth, Manolis Pasparakis and Markus Schwaninger
Nature Medicine 11: 1322-1329; advance online publication, November 13, 2005; doi:10.1038/nm1323
Selective inactivation or reconstitution of adenosine A2A receptors in bone marrow cells reveals their significant contribution to the development of ischemic brain injury
Liqun Yu, Zhihong Huang, Juliana Mariani, Yumei Wang, Michael Moskowitz and Jiang-Fan Chen
Nature Medicine 10: 1081-1087; advance online publication, September 26, 2004; doi:10.1038/nm1103
