TABLE OF CONTENTS

Volume 29, Issue 1 (January 2009)

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Review Article

The role of animal models in evaluating reasonable safety and efficacy for human trials of cell-based interventions for neurologic conditions FREE

Alan Regenberg, Debra JH Mathews, David M Blass, Hilary Bok, Joseph T Coyle, Patrick Duggan, Ruth Faden, Julia Finkel, John D Gearhart, Argye Hillis, Ahmet Hoke, Richard Johnson, Michael Johnston, Jeffrey Kahn, Douglas Kerr, Patricia King, Joanne Kurtzberg, S Matthew Liao, John W McDonald, Guy McKhann, Karin B Nelson, Mahendra Rao, Andrew W Siegel, Kirby Smith, Davor Solter, Hongjun Song, Jeremy Sugarman, Angelo Vescovi, Wise Young, Henry T Greely and Richard J Traystman

J Cereb Blood Flow Metab 29: 1-9; advance online publication, August 27, 2008; doi:10.1038/jcbfm.2008.98

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Rapid Communications

New insights into central roles of cerebral oxygen metabolism in the resting and stimulus-evoked brain FREE

Xiao-Hong Zhu, Nanyin Zhang, Yi Zhang, Kâmil Ug breveurbil and Wei Chen

J Cereb Blood Flow Metab 29: 10-18; advance online publication, September 10, 2008; doi:10.1038/jcbfm.2008.97

Multimodal measurements of blood plasma and red blood cell volumes during functional brain activation FREE

Peter Herman, Basavaraju G Sanganahalli and Fahmeed Hyder

J Cereb Blood Flow Metab 29: 19-24; advance online publication, September 3, 2008; doi:10.1038/jcbfm.2008.100

Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood–brain barrier FREE

Rashid Deane, Barbra LaRue, Abhay P Sagare, Francis J Castellino, Zhihui Zhong and Berislav V Zlokovic

J Cereb Blood Flow Metab 29: 25-33; advance online publication, October 8, 2008; doi:10.1038/jcbfm.2008.117

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Brief Communications

Circulating CD34-positive cells have prognostic value for neurologic function in patients with past cerebral infarction FREE

Akihiko Taguchi, Nami Nakagomi, Tomohiro Matsuyama, Akie Kikuchi-Taura, Hiroo Yoshikawa, Yukiko Kasahara, Haruka Hirose, Hiroshi Moriwaki, Takayuki Nakagomi, Toshihiro Soma, David M Stern and Hiroaki Naritomi

J Cereb Blood Flow Metab 29: 34-38; advance online publication, August 13, 2008; doi:10.1038/jcbfm.2008.92

Neuregulin-1 signaling in brain endothelial cells FREE

Josephine Lok, S Pablo Sardi, Shuzhen Guo, Elaine Besancon, Duy M Ha, Anna Rosell, Woo Jean Kim, Gabriel Corfas and Eng H Lo

J Cereb Blood Flow Metab 29: 39-43; advance online publication, August 27, 2008; doi:10.1038/jcbfm.2008.94

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Original Articles

Stimulation-induced increases of astrocytic oxidative metabolism in rats and humans investigated with 1-11C-acetate FREE

Matthias T Wyss, Bruno Weber, Valerie Treyer, Stefan Heer, Luc Pellerin, Pierre J Magistretti and Alfred Buck

J Cereb Blood Flow Metab 29: 44-56; advance online publication, August 20, 2008; doi:10.1038/jcbfm.2008.86

Cytosolic Ca2+ oscillations in human cerebrovascular endothelial cells after subarachnoid hemorrhage FREE

Wolfram Scharbrodt, Yaser Abdallah, Sascha A Kasseckert, Dragan Gligorievski, Hans M Piper, Dieter-K Böker, Wolfgang Deinsberger and Matthias F Oertel

J Cereb Blood Flow Metab 29: 57-65; advance online publication, August 13, 2008; doi:10.1038/jcbfm.2008.87

The neuroprotective effect of prostaglandin E2 EP1 receptor inhibition has a wide therapeutic window, is sustained in time and is not sexually dimorphic FREE

Takato Abe, Alexander Kunz, Munehisa Shimamura, Ping Zhou, Josef Anrather and Costantino Iadecola

J Cereb Blood Flow Metab 29: 66-72; advance online publication, July 23, 2008; doi:10.1038/jcbfm.2008.88

Tumor necrosis factor receptor-1 is essential for LPS-induced sensitization and tolerance to oxygen–glucose deprivation in murine neonatal organotypic hippocampal slices FREE

Tina Markus, Tobias Cronberg, Corrado Cilio, Cornelis Pronk, Tadeusz Wieloch and David Ley

J Cereb Blood Flow Metab 29: 73-86; advance online publication, August 27, 2008; doi:10.1038/jcbfm.2008.90

Comparative neuroprotective effects of cyclosporin A and NIM811, a nonimmunosuppressive cyclosporin A analog, following traumatic brain injury FREE

Lamin HAN Mbye, Indrapal N Singh, Kimberly M Carrico, Kathryn E Saatman and Edward D Hall

J Cereb Blood Flow Metab 29: 87-97; advance online publication, August 20, 2008; doi:10.1038/jcbfm.2008.93

C3a receptor antagonist attenuates brain injury after intracerebral hemorrhage FREE

Michal A Rynkowski, Grace H Kim, Matthew C Garrett, Brad E Zacharia, Marc L Otten, Sergei A Sosunov, Ricardo J Komotar, Benjamin G Hassid, Andrew F Ducruet, John D Lambris and E Sander Connolly

J Cereb Blood Flow Metab 29: 98-107; advance online publication, August 27, 2008; doi:10.1038/jcbfm.2008.95

Determination of the glutamate–glutamine cycling flux using two-compartment dynamic metabolic modeling is sensitive to astroglial dilution FREE

Jun Shen, Douglas L Rothman, Kevin L Behar and Su Xu

J Cereb Blood Flow Metab 29: 108-118; advance online publication, September 3, 2008; doi:10.1038/jcbfm.2008.102

Normobaric hyperoxia and delayed tPA treatment in a rat embolic stroke model FREE

Nils Henninger, Bernt T Bratane, Birgul Bastan, James Bouley and Marc Fisher

J Cereb Blood Flow Metab 29: 119-129; advance online publication, September 3, 2008; doi:10.1038/jcbfm.2008.104

Blocking glucocorticoid and enhancing estrogenic genomic signaling protects against cerebral ischemia FREE

Michelle Y Cheng, Guohua Sun, Michael Jin, Heng Zhao, Gary K Steinberg and Robert M Sapolsky

J Cereb Blood Flow Metab 29: 130-136; advance online publication, September 17, 2008; doi:10.1038/jcbfm.2008.105

Intracerebral hemorrhage leads to infiltration of several leukocyte populations with concomitant pathophysiological changes FREE

Matthew C Loftspring, Jeremiah McDole, Aigang Lu, Joseph F Clark and Aaron J Johnson

J Cereb Blood Flow Metab 29: 137-143; advance online publication, October 1, 2008; doi:10.1038/jcbfm.2008.114

A functional magnetic resonance imaging technique based on nulling extravascular gray matter signal FREE

Yuji Shen, Risto A Kauppinen, Rishma Vidyasagar and Xavier Golay

J Cereb Blood Flow Metab 29: 144-156; advance online publication, August 27, 2008; doi:10.1038/jcbfm.2008.96

Homocysteine reduces endothelial progenitor cells in stroke patients through apoptosis FREE

Mohammad Murshedul Alam, Askar A Mohammad, Umar Shuaib, Chenxu Wang, Usman Ghani, Brenda Schwindt, Kathryn G Todd and Ashfaq Shuaib

J Cereb Blood Flow Metab 29: 157-165; advance online publication, September 3, 2008; doi:10.1038/jcbfm.2008.99

Persisting depletion of brain glucose following cortical spreading depression, despite apparent hyperaemia: evidence for risk of an adverse effect of Leão's spreading depression FREE

Parastoo Hashemi, Robin Bhatia, Hajime Nakamura, Jens P Dreier, Rudolf Graf, Anthony J Strong and Martyn G Boutelle

J Cereb Blood Flow Metab 29: 166-175; advance online publication, September 24, 2008; doi:10.1038/jcbfm.2008.108

Hemodynamic changes after visual stimulation and breath holding provide evidence for an uncoupling of cerebral blood flow and volume from oxygen metabolism FREE

Manus J Donahue, Robert D Stevens, Michiel de Boorder, James J Pekar, Jeroen Hendrikse and Peter C M van Zijl

J Cereb Blood Flow Metab 29: 176-185; advance online publication, September 17, 2008; doi:10.1038/jcbfm.2008.109

Evaluation of the novel 5-HT4 receptor PET ligand [11C]SB207145 in the Göttingen minipig FREE

Birgitte R Kornum, Nanna M Lind, Nic Gillings, Lisbeth Marner, Flemming Andersen and Gitte M Knudsen

J Cereb Blood Flow Metab 29: 186-196; advance online publication, September 17, 2008; doi:10.1038/jcbfm.2008.110

Magnetic resonance imaging assessment of regional cerebral blood flow after asphyxial cardiac arrest in immature rats FREE

Mioara D Manole, Lesley M Foley, T Kevin Hitchens, Patrick M Kochanek, Robert W Hickey, Hülya Bayir, Henry Alexander, Chien Ho and Robert SB Clark

J Cereb Blood Flow Metab 29: 197-205; advance online publication, October 1, 2008; doi:10.1038/jcbfm.2008.112

Quantitative assessment of water pools by T 1rho and T 2rho MRI in acute cerebral ischemia of the rat FREE

Kimmo T Jokivarsi, Juha-Pekka Niskanen, Shalom Michaeli, Heidi I Gröhn, Michael Garwood, Risto A Kauppinen and Olli H Gröhn

J Cereb Blood Flow Metab 29: 206-216; advance online publication, October 1, 2008; doi:10.1038/jcbfm.2008.113

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Commentary

Multimodal magnetic resonance imaging for assessing evolution of ischemic penumbra: a key translational medicine strategy to manage the risk of developing novel therapies for acute ischemic stroke FREE

Juan C Chavez, Margaret M Zaleska, Xinkang Wang, Andrew Wood, Orest Hurko, Menelas N Pangalos and Giora Z Feuerstein

J Cereb Blood Flow Metab 29: 217-219; advance online publication, September 3, 2008; doi:10.1038/jcbfm.2008.103

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