Journal of Cerebral Blood Flow & Metabolism

FIGURE 1

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Prevention of apoptosis-inducing factor translocation is a possible mechanism for protective effects of hepatocyte growth factor against neuronal cell death in the hippocampus after transient forebrain ischemia

Makiko Niimura, Norio Takagi, Keiko Takagi, Reiko Mizutani, Naoko Ishihara, Kunio Matsumoto, Hiroshi Funakoshi, Toshikazu Nakamura and Satoshi Takeo

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Figure 1.

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Effect of hepatocytes growth factor (HGF) on neuronal cell death in the hippocampal cornu ammonis (CA) subregion 1 (CA1) region after transient forebrain ischemia. (A–C) Photomicrographs of cresyl violet-stained hippocampal CA1 region of nonoperated naïve rats (A), four-vessel-occluded rats not treated with (B), or treated (C) with HGF at 10 mug/3 days/animal. (D–F) Photomicrographs of terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL)-stained hippocampal CA1 region from nonoperated naïve rats (D), four-vessel-occluded rats not treated with (E), or treated (F) with HGF at 10 mug/3 days/animal. Scale bar represents 50 mum.

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