Journal of Cerebral Blood Flow & Metabolism

FIGURE 1

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Monocyte chemoattractant protein-1 regulation of blood−brain barrier permeability

Svetlana M Stamatovic, Parvin Shakui, Richard F Keep, Bethany B Moore, Steven L Kunkel, Nico Van Rooijen and Anuska V Andjelkovic

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Figure 1.

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Intracerebral administration of monocyte chemoattractant protein (MCP-1) induces fluorescein isothiocyanate (FITC)-albumin leakage in the brain. FITC-albumin leakage into mouse brain was assayed at 6,12, 24 and 48 h after an acute dose of recombinant murine MCP-1 (25 mug) or after long-term infusion for 3 (5 mug/h) or 7 days (2.5 mug/h). Mice treated with saline were used as control. (A) Quantitative analysis of MCP-1 induced FITC-albumin leakage in the brain after intracerebral MCP-1 treatment. Values are Meansplusminuss.d., #P<0.001 compared with control, (n=5 animals per group). (B) Representative images of FITC-albumin leakage in the brain after intracerebral MCP-1 treatment. Scale bar=1000 mum.

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