Journal of Cerebral Blood Flow & Metabolism

FIGURE 2

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Obligatory role of inducible nitric oxide synthase in ischemic preconditioning

Sunghee Cho, Eun-Mi Park, Ping Zhou, Kelly Frys, M Elizabeth Ross and Costantino Iadecola

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Figure 2.

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Time window of neuroprotection after preconditioning (IPC). (A) Cerebral blood flow during bilateral carotid artery occlusions (BCCAO)(average of 3 episodes) and at 3 mins of reperfusion (Rep). (B) Cerebral blood flow during MCAO (20-min average) and at 10 mins of reperfusion. (C) Coronal brain sections illustrating the rostrocaudal distribution of the infarct 3 days after MCAO in sham-operated (Sham) and preconditioned animals (IPC). The time interval between preconditioning and MCAO was 24 h. (D) Infarct volume 3, 24, and 72 h after preconditioning. For all panels, n=4 to 5 for each group. * P<0.05 from sham, analysis of variance, and post hoc Fisher's PLSD test.

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