Journal of Cerebral Blood Flow & Metabolism

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Minocycline protects against permanent cerebral ischemia in wild type but not in matrix metalloprotease-9-deficient mice

Milla Koistinaho, Tarja M Malm, Mikko I Kettunen, Gundars Goldsteins, Sofie Starckx, Risto A Kauppinen, Ghislain Opdenakker and Jari Koistinaho

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Figure 1.

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Minocycline protects against permanent focal ischemic damage. (A) Typical examples of TTC-stained brain sections showing ischemic lesions as white areas in saline and minocycline-treated FVB/N mice at 24 hours after the onset of MCA occlusion. The treatments were started 12 hours before ischemic insult. (B) Quantitative data of infarct volumes in saline and minocycline-treated FVB/N mice. Data are shown as meanplusminuss.e.m. ** P0.01, t-test; mino, minocycline.

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