TABLE 3

FROM:

Identification of Potential Stroke Targets by Lentiviral Vector Mediated Overexpression of HIF-1 and HIF-2 in a Primary Neuronal Model of Hypoxia

G S Ralph, S Parham, S R Lee, G L Beard, M H Craigon, N Ward, J R White, R D Barber, W Rayner, S M Kingsman, C R Mundy, N D Mazarakis and D Krige

Table 3. Summary of HIF-1 or HIF-2 requiring EST orthologues

Classification/Accession no	Orthologue Unigene No.	Identity (%)	Gene Name	HIF-1/2 requiring	Hypoxic regulation in literature	Fold change
HIF-1 and HIF-2 requiring ESTs were assigned mouse or human orthologues by sequence alignment analysis using BLAT. Details of the sequence identity between ESTs and their othologues are included. Approximately 65% of the ESTs identified in this study were assigned gene names. Previous evidence for hypoxic regulation was assessed by literature searching.
Cell surface
AA850824	Mm.21767	93.1	Cadherin 5	HIF-2	Yes	2.6
AA997859	Mm.32780	92.6	Megalencephalic leukoencephalopathy with subcortical cysts 1	HIF-2	No	2.6
AI236084	Mm.198677	87.6	TNF receptor superfamily, member 9	HIF-2	No	2.2
AI029070	Mm.80509	90.7	Cell adhesion molecule-related/down-regulated by oncogenes	HIF-1	No	2.1
AI071185	Mm.10760	88.3	Oncostatin receptor	HIF-2	No	2.1
AI045718	Mm.4787	93.6	G protein-coupled receptor 19	HIF-2	No	2.1
AI137286	Mm.136736	85.4	Sphingolipid G-protein-coupled receptor 3	HIF-2	No	2
Transcription
AI072904	Hs.334481	94.8	DMRT-like family A2	HIF-2	No	4.9
AI009128	Mm.8009	92.0	Polymerase I and transcript release factor	HIF-2	No	4
AI044253	Mm.479	94.4	Myeloblastosis oncogene-like 1	HIF-1	No	3.7
AI169152	Mm.233891	92.0	V-maf musculoaponeurotic fibrosarcoma oncogene B	HIF-1/2	No	3.2/8.4
AA924764	Mm.38497	83.8	Promyelocytic leukaemia protein	HIF-2	Yes	3.1
AA900290	Mm.86541	89.6	Carbon catabolite repression 4	HIF-2	No	2.5
AA850244	Mm.7320	92.1	MAD homologue 3	HIF-2	No	2.4
AI012356	Mm.196029	91.7	Stat3	HIF-2	Yes	2.1
AI171303	Hs.16803	94.4	Sarcoplasmic reticulum protein LUC7L	HIF-1	No	2.1
AI228589	Mm.5116	95.6	Cut-like 2	HIF-2	No	2
AI030339	Mm.56	86.8	Down syndrome critical region homologue 1	HIF-2	No	2
AI070558	Mm.116683	89.7	TNF-induced protein 3	HIF-1/2	No	2/2
Enzymatic
AA956900	Hs.154510	89.5	Carbonyl reductase 3	HIF-2	Yes	2.3
AI178139	Mm.31175	88.2	AMP-activated protein kinase b-2 regulatory subunit	HIF-1/2	No	2.3/2.6
AI102833	Mm.88747	88.4	Cyclin-dependent kinase 6	HIF-2	No	2.3
AI029291	Mm.30088	94.0	Caseinolytic protease X	HIF-2	No	2.1
AI228147	Hs.20695		Rho guanine nucleotide exchange factor 10	HIF-2	No	2.1
Other
AA964627	Mm.22213	94.2	Glioma pathogenesis-related 2	HIF-2	No	3.1
AI112802	Mm.3057	92.3	Reelin	HIF-1/2	No	2.9/2.7
AI178504	Mm.4063	90.4	N-myc downstream regulated gene 1	HIF-2	Yes	2.8
AI031002	Mm.21921	90.5	CDC42 effector protein (Rho GTPase binding) 4	HIF-1/2	No	2.6/2.5
AA874803	Mm.30211	91.4	Chemokine (C-X-C motif) 14	HIF-2	No	2.5
AA850334	Mm.196846	93.7	RAD23b	HIF-2	No	2.4
AI230750	Mm.46662	94.5	Dapper 1	HIF-2	No	2.4
AI070068	Mm.1360	91.9	GADD45	HIF-2	Yes	2.3
AA964541	Mm.4964	91.1	Leukemia inhibitory factor	HIF-2	Yes	2.3
AA965115	Mm.45357	97.9	Erbb2 interacting protein	HIF-1	No	2.2
AA943397	Mm.3350	93.2	Microtubule-actin crosslinking factor 1	HIF-2	No	2.1
Unknown
AI176280	Hs.238996	95.9	Hypothetical protein DKFZp434K0427	HIF-2	No	4.4
AI235748	Mm.27787	89.7	RIKEN cDNA 0610009D16 gene	HIF-2	No	2.5
AI044628	Hs.23518	91.7	Hypothetical protein from BCRA2 region	HIF-1/2	No	2.2/2
AI169231	Mm.21679	92.1	RIKEN cDNA 1300002F13 gene	HIF-2	No	2.1
AI237646	Hs.99196	87.2	Hypothetical protein MGC11324	HIF-1/2	No	2/2.3
AI007964	Mm.38167	94.2	RIKEN cDNA 3010033109 gene	HIF-2	No	2