Journal of Cerebral Blood Flow & Metabolism

FIGURE 2

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Triptans Reduce the Inflammatory Response in Bacterial Meningitis

Olaf Hoffmann, Nikolas Keilwerth, Margarethe Bastholm Bille, Uwe Reuter, Klemens Angstwurm, Ralf R Schumann, Ulrich Dirnagl and Joerg R Weber

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Figure 2.

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(A) Intracranial pressure (ICP) is significantly increased in pneumococcal cell wall (PCW)-induced meningitis. Increase is inhibited by naratriptan and zolmitriptan started at 0 hours or by zolmitriptan started at 2 hours. (B) Influx of leukocytes into the cerebrospinal fluid (CSF) associated with PCW-induced meningitis is reduced by triptan treatment. *Indicates a significant difference (P < 0.05) compared to untreated meningitis (ANOVA, Duncan post hoc test).

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