FIGURE 2
FROM:
TAK-779, A Nonpeptide CC Chemokine Receptor Antagonist, Protects the Brain Against Focal Cerebral Ischemia in Mice
Shinya Takami, Masabumi Minami, Takahiro Katayama, Izumi Nagata, Shobu Namura and Masamichi Satoh
BACK TO ARTICLEFigure 2.
(A) Infarct volumes at 48 hours after reperfusion. Mice were intracerebroventricularly injected with vehicle or TAK-779 (25 or 250 ng) (n = 12, 10, and 13, respectively). Infarct volumes are presented as a percentage of contralateral hemispheric values. Data are expressed as mean 
SD. * P < 0.05 compared with the vehicle-injected group (ANOVA followed by Bonferroni's post hoc test). (B) Infarct volumes at 48 hours after reperfusion. Mice were intravenously injected with vehicle or TAK-779 (5 
g/20 g body weight; n = 18 and 17, respectively). Infarct volumes are presented as a percentage of contralateral hemispheric values. Data are expressed as mean SD. #P < 0.05 compared with the vehicle-injected group (Student's t-test). (C) Number of myeloperoxidase or Mac-1
positive cells in an area of 500 
500 m2 in the ischemic penumbra at 48 hours after reperfusion. Mice were intravenously injected with vehicle or TAK-779 (n = 5 in each). Data are expressed as mean SD. ##P < 0.01 compared with the vehicle-injected group (Student's t-test).
