Journal of Cerebral Blood Flow & Metabolism

FIGURE 6

FROM:

Magnetic Resonance Angiography of Thromboembolic Stroke in Rats: Indicator of Recanalization Probability and Tissue Survival After Recombinant Tissue Plasminogen Activator Treatment

Thomas Hilger, Frank Niessen, Michael Diedenhofen, Konstantin-Alexander Hossmann and Mathias Hoehn

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Figure 6.

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Apparent diffusion coefficient (ADC) measurements at 6 hours after rt-PA treatment of middle cerebral artery (MCA) clot embolism in the rat. Comparison of animals (means plusminus SD) with and without additional obstruction of circle of Willis (CW). The threshold of the ADC for the breakdown of energy (77% of control;Olah et al., 2001) is marked by the dotted line. Note the decrease of ADC below this threshold in lateral cortex and striatum of animals with combined MCA/CW occlusion but not in the medial cortex or in any region after selective MCA occlusion. These measurements underline the predictive power of magnetic resonance angiography for treatment outcome (P < 0.03).

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