Journal of Cerebral Blood Flow & Metabolism

FIGURE 4

FROM:

Hypoglycemic Brain Injury: Potentiation From Respiratory Depression and Injury Aggravation From Hyperglycemic Treatment Overshoots

Gabrielle M de Courten-Myers, Guohua Xi, Jong-Hee Hwang, R Scott Dunn, Ashley S Mills, Scott K Holland, Kenneth R Wagner and Ronald E Myers

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Figure 4.

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Brain pathology scores of cats exposed to hypoglycemia alone (HG group), to euglycemic respiratory depression (RD group), and to combined HG/RD (with their two treatment subgroups). All cats exposed to prolonged hypoglycemia where the cardiorespiratory functions were maintained unchanged (HG group) remained brain-intact. Exposure of cats to euglycemic respiratory depression caused only one in five cats to develop brain injury. In contrast to the low brain injury rates among the HG and RD groups, cats exposed to combined hypoglycemia plus respiratory depression (HG/RD) all showed brain damage (10/10). Of the cats in the HG/RD group, those treated to euglycemia showed significantly less extensive brain damage than did their peers treated to marked hyperglycemic overshoots.

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