TABLE 1
FROM:
Equilibrium Versus Compartmental Analysis for Assessment of the Vesicular Monoamine Transporter Using (+)-
-[11C]Dihydrotetrabenazine (DTBZ) and Positron Emission Tomography
Robert A Koeppe, Kirk A Frey, Akito Kume, Roger Albin, Michael R Kilbourn and David E Kuhl
BACK TO ARTICLETable 1. Comparison of kinetic and equilibrium estimation of DVtot for (+)-()-[11C]DTBZ
| Kinetic | Equilibrium | ||||
|---|---|---|---|---|---|
| Region | 4P LSQ | 2P LSQ | 2P WI | Logan | |
| 4P LSQ, 4 parameter nonlinear least squares estimation; 2p LSQ, 2 parameter nonlinear least squares estimation; 2P WI, 2 parameter weighted integral estimation; Logan, graphical analysis as described by Logan et al. (1990). | |||||
| Kinetic estimates are derived from data 0 to 60 minutes. Equilibrium estimates are derived from data 30 to 60 minutes | |||||
| Putamen | |||||
| Dvtot (mL/g) | 11.72 21% | 11.2720% | 12.2820% | 11.5021% | 10.9921% |
| %Diff from DVtot(eq) | 6.15.6% | 3.07.8% | 12.05.8% | 4.75.1% | |
| P | 0.011 | 0.39 | 0.0006 | 0.0042 | |
| Caudate | |||||
| DVtot(mL/g) | 12.3721% | 11.9319% | 12.9416% | 11.8520% | 11.3721% |
| % Diff from DVtot(eq) | 8.16.7% | 5.89.7% | 15.18.0% | 4.66.8% | |
| P | 0.0049 | 0.20 | 0.0008 | 0.15 | |
| Thalamus | |||||
| DVtot (mL/g) | 5.1219% | 4.6221% | 4.7120% | 4.7619% | 5.0122% |
| % Diff from DVtot(eq) | 2.38.2% | -6.57.2% | -5.07.0% | -3.96.1% | |
| P | 0.33 | 0.019 | 0.048 | 0.053 | |
| Frontal Cortex | |||||
| DVtot (mL/g) | 4.5718% | 4.1118% | 4.1116% | 4.2916% | 4.5018% |
| % Diff from DVtot(eq) | 0.35.7% | -8.37.4% | -8.16.7% | -4.15.8% | |
| P | 0.37 | 0.0088 | 0.0082 | 0.054 | |
| Cerebellum | |||||
| DVtot (mL/g) | 4.7022% | 4.2123% | 4.3620% | 4.3720% | 4.5622% |
| % Diff from DVtot(eq) | 0.76.5% | -7.27.6% | -4.56.7% | -4.05.3% | |
| P | 0.23 | 0.012 | 0.099 | 0.055 | |
