Journal of Cerebral Blood Flow & Metabolism

FIGURE 8

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Optimization of Noninvasive Activation Studies with 15O-Water and Three-Dimensional Positron Emission Tomography

Norihiro Sadato, Richard E Carson, Margaret E Daube-Witherspoon, Gregory Campbell, Mark Hallett and Peter Herscovitch

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Figure 8.

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The peak S/Npix for 5% change in rCBF at rCBF = 80 mL/min/100 g with various doses of 15O-water obtained by scans of varying durations. Data for a bolus injection (closed square), and for slow infusions of 1 minute (open circle), 2 minutes (closed circle), and 3 minutes (open triangle) are shown. Scan durations were 1 minute for the bolus injection, and 1.5, 2.0, and 3.0 minutes for the simulated slow injections of 1, 2, and 3 minutes, respectively.

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