TABLE 1
FROM:
Neuroprotective Effects of Human Recombinant Interleukin-1 Receptor Antagonist in Focal Cerebral Ischaemia in the Rat
Sarah A Loddick and Nancy J Rothwell
BACK TO ARTICLETable 1. Effects of rhIL-1ra on blood pressure (BP) and heart rate (HR) after MCAo
| Change in BP (mmHg) | Change in HR (bpm) | |||
|---|---|---|---|---|
| Time post-MCAo (min) | Saline | IL-1ra | Saline | IL-1ra |
Data are presented as change in BP or HR from mean values recorded over 30 min prior to MCAo in animals treated with either saline (n = 6) or rhIL-1ra (n = 6, 10 g, icv, 30 min before MCAo). | ||||
| 5 | 2 2 | 5 1 | 5 3 | 3 3 |
| 10 | 9 3 | 1 2 | 22 10 | -15 18 |
| 15 | 11 7 | 3 2 | 28 23 | 8 21 |
| 20 | 19 8 | 5 1 | 40 26 | 17 22 |
| 30 | 17 7 | 5 3 | 27 31 | -1 37 |
| 45 | 16 8 | 2 2 | 15 32 | 0 20 |

g, icv, 30 min before MCAo).
2