TABLE OF CONTENTS

Volume 70, Issue 5 (May 2017)

Special Issue Dedicated to Satoshi Ōmura: A leader and an inspiration in natural products chemistry, and the Nobel Prize Laureate in Physiology or Medicine 2015

We are very honored and pleased to dedicate this May issue of The Journal of Antibiotics to Professor Satoshi Ōmura, in recognition of his 2015 Nobel Prize in Physiology or Medicine and his other great achievements. Accordingly, the issue also includes a list and overview of all 181 new compounds he has discovered in his 50-year career, encompassing nearly 500 compounds total. We are grateful to have received so many contributions from researchers all over the world, who hold Professor Ōmura in high esteem.
We would like to thank Managing Editor Dr. Kazuro Shiomi, the coordinator of this issue, for his hard work in planning and coordinating this very special publication.

The Journal of Antibiotics

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Editorials

Foreword celebrating the career of Professor Satoshi Ōmura FREE

Kuniaki Tatsuta

J Antibiot 70: 455-456; doi:10.1038/ja.2017.25

Achievements of Professor Satoshi Ōmura FREE

Kazuro Shiomi

J Antibiot 70: 457-491; doi:10.1038/ja.2017.36

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Perspective

The ups and downs of drug discovery: the early history of Fidaxomicin FREE

James B McAlpine

J Antibiot 70: 492-494; advance online publication, January 18, 2017; doi:10.1038/ja.2016.157

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Review Articles

Ivermectin: enigmatic multifaceted ‘wonder’ drug continues to surprise and exceed expectations FREE

Andy Crump

J Antibiot 70: 495-505; advance online publication, February 15, 2017; doi:10.1038/ja.2017.11

Genus Kitasatospora, taxonomic features and diversity of secondary metabolites FREE

Yōko Takahashi

J Antibiot 70: 506-513; advance online publication, February 15, 2017; doi:10.1038/ja.2017.8

Endophytic actinomycetes: promising source of novel bioactive compounds FREE

Atsuko Matsumoto and Yōko Takahashi

J Antibiot 70: 514-519; advance online publication, March 8, 2017; doi:10.1038/ja.2017.20

The antibiotic resistance crisis, with a focus on the United States FREE

Evan Martens and Arnold L Demain

J Antibiot 70: 520-526; advance online publication, March 1, 2017; doi:10.1038/ja.2017.30

Nature nurtures the design of new semi-synthetic macrolide antibiotics Open

Prabhavathi Fernandes, Evan Martens and David Pereira

J Antibiot 70: 527-533; advance online publication, November 30, 2016; doi:10.1038/ja.2016.137

The master regulator PhoP coordinates phosphate and nitrogen metabolism, respiration, cell differentiation and antibiotic biosynthesis: comparison in Streptomyces coelicolor and Streptomyces avermitilis FREE

Juan F Martín, Antonio Rodríguez-García and Paloma Liras

J Antibiot 70: 534-541; advance online publication, March 15, 2017; doi:10.1038/ja.2017.19

Tyropeptins, proteasome inhibitors produced by Kitasatospora sp. MK993-dF2 FREE

Isao Momose and Takumi Watanabe

J Antibiot 70: 542-550; advance online publication, February 15, 2017; doi:10.1038/ja.2017.9

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Correspondence

Message from a long-time friend: congratulations on Emeritus Professor Satoshi Ōmura’s accomplishments FREE

James B McAlpine

J Antibiot 70: 551-552; doi:10.1038/ja.2017.43

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Original Articles

Enhanced dereplication of fungal cultures via use of mass defect filtering Open

Noemi D Paguigan, Tamam El-Elimat, Diana Kao, Huzefa A Raja, Cedric J Pearce and Nicholas H Oberlies

J Antibiot 70: 553-561; advance online publication, January 11, 2017; doi:10.1038/ja.2016.145

Naphthacemycins, novel circumventors of β-lactam resistance in MRSA, produced by Streptomyces sp. KB-3346-5. I. The taxonomy of the producing strain, and the fermentation, isolation and antibacterial activities FREE

Atsushi Fukumoto, Yong-Pil Kim, Atsuko Matsumoto, Yoko Takahashi, Makoto Suzuki, Hideyuki Onodera, Hiroshi Tomoda, Hidehito Matsui, Hideaki Hanaki, Masato Iwatsuki, Satoshi Ōmura and Kazuro Shiomi

J Antibiot 70: 562-567; advance online publication, March 15, 2017; doi:10.1038/ja.2017.28

Naphthacemycins, novel circumventors of β-lactam resistance in MRSA, produced by Streptomyces sp. KB-3346-5. II. Structure elucidation FREE

Atsushi Fukumoto, Yong-Pil Kim, Masato Iwatsuki, Tomoyasu Hirose, Toshiaki Sunazuka, Hideaki Hanaki, Satoshi Ōmura and Kazuro Shiomi

J Antibiot 70: 568-573; advance online publication, March 15, 2017; doi:10.1038/ja.2017.29

Total synthesis of (±)-naphthacemycin A9, possessing both antibacterial activity against methicillin-resistant Staphylococcus aureus and circumventing effect of β-lactam resistance FREE

Tomoyasu Hirose, Yasuhiro Kojima, Hidehito Matsui, Hideaki Hanaki, Masato Iwatsuki, Kazuro Shiomi, Satoshi Ōmura and Toshiaki Sunazuka

J Antibiot 70: 574-581; advance online publication, December 7, 2016; doi:10.1038/ja.2016.141

Kribellosides, novel RNA 5′-triphosphatase inhibitors from the rare actinomycete Kribbella sp. MI481-42F6 FREE

Masayuki Igarashi, Ryuichi Sawa, Manabu Yamasaki, Chigusa Hayashi, Maya Umekita, Masaki Hatano, Toshinobu Fujiwara, Kiyohisa Mizumoto and Akio Nomoto

J Antibiot 70: 582-589; advance online publication, January 11, 2017; doi:10.1038/ja.2016.161

Isomethoxyneihumicin, a new cytotoxic agent produced by marine Nocardiopsis alba KM6-1 FREE

Takashi Fukuda, Misaki Takahashi, Kenichiro Nagai, Enjuro Harunari, Chiaki Imada and Hiroshi Tomoda

J Antibiot 70: 590-594; advance online publication, December 21, 2016; doi:10.1038/ja.2016.152

Antarlides F–H, new members of the antarlide family produced by Streptomyces sp. BB47 FREE

Shun Saito, Takahiro Fujimaki, Watanalai Panbangred, Ryuichi Sawa, Yasuhiro Igarashi and Masaya Imoto

J Antibiot 70: 595-600; advance online publication, February 8, 2017; doi:10.1038/ja.2017.6

Elmenols C-H, new angucycline derivatives isolated from a culture of Streptomyces sp. IFM 11490 FREE

 Yixizhuoma, Naoki Ishikawa, Mohamed S Abdelfattah and Masami Ishibashi

J Antibiot 70: 601-606; advance online publication, January 11, 2017; doi:10.1038/ja.2016.158

Simamycin (5′-O-geranyluridine): a new prenylated nucleoside from Streptomyces sp. FREE

Yasuhiro Igarashi, Takayuki Kyoso, Youngju Kim and Tsutomu Oikawa

J Antibiot 70: 607-610; advance online publication, January 18, 2017; doi:10.1038/ja.2016.163

Fradiamine A, a new siderophore from the deep-sea actinomycete Streptomyces fradiae MM456M-mF7 FREE

Yasuhiro Takehana, Maya Umekita, Masaki Hatano, Chiaki Kato, Ryuichi Sawa and Masayuki Igarashi

J Antibiot 70: 611-615; advance online publication, March 1, 2017; doi:10.1038/ja.2017.26

Characterization of bafilomycin biosynthesis in Kitasatospora setae KM-6054 and comparative analysis of gene clusters in Actinomycetales microorganisms FREE

Ayako Nara, Takuya Hashimoto, Mamoru Komatsu, Makoto Nishiyama, Tomohisa Kuzuyama and Haruo Ikeda

J Antibiot 70: 616-624; advance online publication, March 15, 2017; doi:10.1038/ja.2017.33

Incubation of 2-methylisoborneol synthase with the intermediate analog 2-methylneryl diphosphate FREE

Wayne KW Chou, Colin A Gould and David E Cane

J Antibiot 70: 625-631; advance online publication, March 1, 2017; doi:10.1038/ja.2017.24

Cyclization mechanism of phomopsene synthase: mass spectrometry based analysis of various site-specifically labeled terpenes FREE

Sandip S Shinde, Atsushi Minami, Zhi Chen, Tetsuo Tokiwano, Tomonobu Toyomasu, Nobuo Kato, Takeshi Sassa and Hideaki Oikawa

J Antibiot 70: 632-638; advance online publication, March 8, 2017; doi:10.1038/ja.2017.27

Molecular beacons to identify gifted microbes for genome mining FREE

Richard H Baltz

J Antibiot 70: 639-646; advance online publication, January 25, 2017; doi:10.1038/ja.2017.1

Development of a new air-stable structure-simplified nafuredin-γ analog as a potent and selective nematode complex I inhibitor FREE

Masaki Ohtawa, Shiho Arima, Risa Shimizu, Naomi Hanatani, Eri Shimizu, Kazuro Shiomi, Kiyoshi Kita, Satoshi Ōmura and Tohru Nagamitsu

J Antibiot 70: 647-654; advance online publication, February 22, 2017; doi:10.1038/ja.2017.16

Synthesis and antibacterial activity of novel lincomycin derivatives. II. Exploring (7S)-7-(5-aryl-1,3,4-thiadiazol-2-yl-thio)-7-deoxylincomycin derivatives FREE

Ko Kumura, Yoshinari Wakiyama, Kazutaka Ueda, Eijiro Umemura, Takashi Watanabe, Megumi Kumura, Takuji Yoshida and Keiichi Ajito

J Antibiot 70: 655-663; advance online publication, December 7, 2016; doi:10.1038/ja.2016.139

Lipophilic teicoplanin pseudoaglycon derivatives are active against vancomycin- and teicoplanin-resistant enterococci FREE

Zsolt Szűcs, Ilona Bereczki, Magdolna Csávás, Erzsébet Rőth, Anikó Borbás, Gyula Batta, Eszter Ostorházi, Réka Szatmári and Pál Herczegh

J Antibiot 70: 664-670; advance online publication, February 1, 2017; doi:10.1038/ja.2017.2

Thiazomycin, nocathiacin and analogs show strong activity against clinical strains of drug-resistant Mycobacterium tuberculosis FREE

Sheo B Singh, Libo Xu, Peter T Meinke, Natalia Kurepina, Barry N Kreiswirth, David B Olsen and Katherine Young

J Antibiot 70: 671-674; advance online publication, January 18, 2017; doi:10.1038/ja.2016.165

The synthesis and evaluation of the antiproliferative activity of deacidified GEX1A analogues FREE

Takamichi Imaizumi, Hiroshi Nakagawa, Ran Hori, Yasuo Watanabe, Shiro Soga, Kyoichiro Iida and Hideyuki Onodera

J Antibiot 70: 675-679; advance online publication, January 18, 2017; doi:10.1038/ja.2016.166

Ivermectin efficacy against Biomphalaria, intermediate host snail vectors of Schistosomiasis FREE

Naftale Katz, Neusa Araújo, Paulo Marcos Zech Coelho, Carlos Medicis Morel, Ana Rosa Linde-Arias, Takeshi Yamada, Yuki Horimatsu, Koh Suzuki, Toshiaki Sunazuka and Satoshi Ōmura

J Antibiot 70: 680-684; advance online publication, March 15, 2017; doi:10.1038/ja.2017.31

Anti-Mycobacterium activity of microbial peptides in a silkworm infection model with Mycobacterium smegmatis FREE

Akiho Yagi, Ryuji Uchida, Hiroshi Hamamoto, Kazuhisa Sekimizu, Ken-ichi Kimura and Hiroshi Tomoda

J Antibiot 70: 685-690; doi:10.1038/ja.2017.23

MA026, an anti-hepatitis C virus compound, opens tight junctions of the epithelial cell membrane FREE

Yusuke Kanda, Youhei Yamasaki, Satomi Shimura, Shinji Kamisuki, Fumio Sugawara, Yoko Nagumo and Takeo Usui

J Antibiot 70: 691-694; advance online publication, January 18, 2017; doi:10.1038/ja.2016.168

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Notes

γ-Ionylidene-type sesquiterpenoids possessing antimicrobial activity against Porphyromonas gingivalis from Phellinus linteus and their absolute structure determination FREE

Tatsuya Shirahata, Chieko Ino, Fumi Mizuno, Yoshihisa Asada, Masao Hirotani, George A Petersson, Satoshi Ōmura, Takafumi Yoshikawa and Yoshinori Kobayashi

J Antibiot 70: 695-698; advance online publication, March 22, 2017; doi:10.1038/ja.2017.35

Structure and antibacterial activities of new cyclic peptide antibiotics, pargamicins B, C and D, from Amycolatopsis sp. ML1-hF4 FREE

Hideki Hashizume, Ryuichi Sawa, Kazuma Yamashita, Yoshio Nishimura and Masayuki Igarashi

J Antibiot 70: 699-704; advance online publication, March 15, 2017; doi:10.1038/ja.2017.34

Trachyspic acid 19-butyl ester, a new inhibitor of Plk1 polo box domain-dependent recognition from uncharacterized fungus RKGS-F2684 FREE

Toshihiko Nogawa, Noriko Ogita, Yushi Futamura, Shigenori Negishi, Nobumoto Watanabe and Hiroyuki Osada

J Antibiot 70: 705-707; advance online publication, January 18, 2017; doi:10.1038/ja.2016.167

Two new sacrolide-class oxylipins from the edible cyanobacterium Aphanothece sacrum FREE

Naoya Oku, Sayaka Hana, Miyako Matsumoto, Kohsuke Yonejima, Keijiroh Tansei, Yasuhiro Isogai and Yasuhiro Igarashi

J Antibiot 70: 708-709; advance online publication, March 8, 2017; doi:10.1038/ja.2017.32

Competition and co-regulation of spirotoamide and tautomycetin biosynthesis in Streptomyces griseochromogenes, and isolation and structural elucidation of spirotoamide C and D FREE

Dong Yang, Mostafa E Rateb, Nan Wang and Ben Shen

J Antibiot 70: 710-714; advance online publication, February 15, 2017; doi:10.1038/ja.2017.13

Synergistic antifungal indolecarbazoles from Streptomyces sp. CNS-42 associated with traditional Chinese medicine Alisma orientale FREE

Mei Liu, Pei Huang, Qian Wang, Biao Ren, Ayokunmi Oyeleye, Miaomiao Liu, Jingyu Zhang, Xiaolin Li, Xiaoping Zhang, Lixin Zhang and Xueting Liu

J Antibiot 70: 715-717; advance online publication, January 11, 2017; doi:10.1038/ja.2016.160

Precursor-directed in situ synthesis of Saccharothriolides G and H by the Actinomycete Saccharothrix sp. A1506 FREE

Shan Lu, Shinichi Nishimura, Masashi Ito, Taira Kato and Hideaki Kakeya

J Antibiot 70: 718-720; advance online publication, December 21, 2016; doi:10.1038/ja.2016.153

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