Achievements of Professor Satoshi Ōmura

During his 50 years of pioneering research, Professor Satoshi Ōmura, Nobel Laureate and Emeritus Editor-in-Chief of The Journal of Antibiotics, has discovered 181 groups of new microbial metabolites, encompassing nearly 500 compounds. This editorial lists those groups, together with a representative chemical structure, producing strains and the initial publication (Figure 1 and Table 1). For much of his storied career, Professor Satoshi Ōmura has also been intimately linked with The Journal of Antibiotics and we are extremely proud that he has published 87% of his initial new compound publications in this journal. Professor Ōmura’s philosophy behind his success has been relatively and refreshing simple, ‘Isolate the greatest variety of microorganisms especially unique species, continually develop innovative assay systems, and perseveringly screen for new and useful bioactive compounds using those microbes and assays.’ The scope, scale and impact of his discoveries prove the merits of such an approach that others would do well to follow. This editorial also shows the complete list of his publication in The Journal of Antibiotics (see list of Publications of Professor Satoshi Ōmura in The Journal of Antibiotics).

Figure 1

Structures of the new compounds discovered by Professor Satoshi Ōmura.

Table 1 List of the producing strains and the initial publications of the new compounds

Publications of Professor Satoshi Ōmura in The Journal of Antibiotics

Publications of Professor Satoshi Ōmura in The Journal of Antibiotics

• 1 Ōmura, Satoshi; Katagiri, Michiko; Hata, Toju. The structures of leucomycins A₄, A₅, A₆, A₇, A₈, and A₉. J. Antibiot. 20(4), 234–235 (1967).

• 2 Sano, Yoshimoto; Nomura, Setsuzo; Kamio, Yoshihiko; Ōmura, Satoshi; Hata, Tojo. Studies on cerulenin. III. Isolation and physic-chemical properties of cerulenin. J. Antibiot. 20(6), 344–348 (1967).

• 3 Ōmura, Satoshi; Katagiri, Michiko; Nakagawa, Akira; Sano, Yoshimoto; Nomura, Setsuzo; Hata, Tojo. Studies on cerulenin. V. Structure of cerulenin. J. Antibiot. 20(6), 349–354 (1967).

• 4 Ōmura, Satoshi; Katagiri, Michiko; Hata, Toju. The chemistry of leucomycins. IV. Structure of leucomycin A₁. J. Antibiot. 21(3), 199–203 (1968).

• 5 Ōmura, Satoshi; Katagiri, Michiko; Hata, Toju. The chemistry of leucomycins. VI. Structures of leucomycin A₄, A₅, A₆, A₇, A₈, and A₉. J. Antibiot. 21(4), 272–278 (1968).

• 6 Ōmura, Satoshi; Katagiri, Michiko; Umezawa, Iwao; Komiyama, Kanki; Maekawa, Tose; Sekikawa, Kenji; Matsumae, Akihiro; Hata, Toju. Structure-biological activity relations among leucomycins and their derivatives. J. Antibiot. 21(9), 532–538 (1968).

• 7 Onda, Masayuki; Konda, Yaeko; Noguchi, Atsuko; Ōmura, Satoshi; Hata, Toju. Revised structure for the naphthalenecarboxylic acid from carzinophilin. J. Antibiot. 22(1), 42–44 (1969).

• 8 Ito, Shinya; Matsuya, Tamiko; Ōmura, Satoshi; Otani, Masaru; Nakagawa, Akira; Takeshima, Hideo; Iwai, Yuzuru; Ohtani, Mariko; Hata, Toju. A new antibiotic, kanamycin. J. Antibiot. 23(6), 316–317 (1970).

• 9 Ōmura, Satoshi; Hironaka, Yukino; Hata, Toju. Chemistry of leucomycin. IX. Identification of leucomycin A₃ with josamycin. J. Antibiot. 23(10), 511–513 (1970).

• 10 Hata, Toju; Ōmura, Satoshi; Iwai, Yuzuru; Nakagawa, Akira; Otani, Masaru; Ito, Shinya; Matsuya, Tamiko. A new antibiotic, kanamycin: fermentation, isolation, purification, and properties. J. Antibiot. 24(6), 353–359 (1971).

• 11 Sato, Tomoyasu; Yamaguchi, Kiyozumi; Katagiri, Michiko; Awaya, Juichi; Iwai, Yuzuru; Ōmura, Satoshi; Hata, Toju. Studies on antibiotic 0-2867, a new antibiotic. J. Antibiot. 24(11), 774–778 (1971).

• 12 Hata, Toju; Ōmura, Satoshi; Katagiri, Michiko; Atsumi, Kiyoo; Awaya, Juichi; Higashikawa, Shizuo; Yasui, Kazuomi; Terada, Haruko; Kuyama, Shimpei. A new antifungal antibiotic, prumycin. J. Antibiot. 24(12), 900–901 (1971).

• 13 Ōmura, Satoshi; Hironaka, Yukino; Nakagawa, Akira; Umezawa, Iwao; Hata, Toju. Antimycoplasma activities of macrolide antibiotics. J. Antibiot. 25(2), 105–108 (1972).

• 14 Nomura, Setsuzo; Horiuchi, Tadashi; Hata, Toju; Ōmura, Satoshi. Inhibition of sterol and fatty acid biosyntheses by cerulenin in cell-free systems of yeast. J. Antibiot. 25(6), 365–368 (1972).

• 15 Hata, Toju; Ōmura, Satoshi; Iwai, Yuzuru; Ohno, Hiroie; Takeshima, Hideo; Yamaguchi, Nobuhito. Studies on Penicillinase inhibitors produced by microorganisms. J. Antibiot. 25(8), 473–474 (1972).

• 16 Ōmura, Satoshi; Suzuki, Yōko; Nakagawa, Akira; Hata, Toju. Fast liquid chromatography of macrolide antibiotics. J. Antibiot. 26(12), 794–796 (1973).

• 17 Arison, Byron H.; Ōmura, Satoshi. Revised structure of cerulenin. J. Antibiot. 27(1), 28–30 (1974).

• 18 Ōmura, Satoshi; Nakagawa, Akira; Suzuki, Kazuhiro; Hata, Toju; Jakubowski, Ann; Tishler, Max. Isolation and structure of leuconolide-A₈ 5,18-hemiacetal and 9-dehydro-18-ihydroleuconolide-A₃. J. Antibiot. 27(2), 147–149 (1974).

• 19 Ōmura, Satoshi; Tanaka, Haruo; Koyama, Yasuaki; Ōiwa, Ruiko; Katagiri, Michiko; Awaya, Juichi; Nagai, Toshiaki; Hata, Toju. Nanaomycins A and B, new antibiotics produced by a strain of Streptomyces. J. Antibiot. 27(5), 363–365 (1974).

• 20 Ōmura, Satoshi; Nakagawa, Akira; Suzuki, Kazuhiro; Hata, Toju. New bicyclo lactone from leucomycin A₃ by alkali treatment. J. Antibiot. 27(5), 370–372 (1974).

• 21 Schwartz, Jeffrey L.; Katagiri, Michiko; Ōmura, Satoshi; Tishler, Max. The mechanism of prumycin action. J. Antibiot. 27(6), 379–385 (1974).

• 22 Satoh, Keiki; Komiyama, Kanki; Kitao, Chiaki; Iwai, Yuzuru; Atsumi, Kiyoo; Ōiwa, Ruiko; Katagiri, Michiko; Umezawa, Iwao; Ōmura, Satoshi; Hata, Toju. Isolation and characterization of a new antitumor antibiotic OS-3256-B from Streptomyces candidus var azaticus. J. Antibiot. 27(8), 620–625 (1974).

• 23 Atsumi, Kiyoo; Ōiwa, Ruiko; Ōmura, Satoshi. Production of bacillin by Bacillus species strain no. KM-208 and its identity with tetaine (bacilysin). J. Antibiot. 28(1), 77–78 (1975).

• 24 Ōmura, Satoshi; Nakagawa, Akira. Chemical and biological studies on 16-membered macrolide antibiotics. J. Antibiot. 28(6), 401–433 (1975).

• 25 Ōmura, Satoshi; Suzuki, Y.; Kitao, C.; Takahashi, Y.; Konda, Y. Isolation of a new sulfur-containing basic substance from a Thermo actinomyces species. J. Antibiot. 28, 609–610 (1975).

• 26 Ōiwa, Ruiko; Katagiri, Michiko; Tanaka, Naohisa; Takahashi, Yoko; Satō, Keiki; Masuma, Rokuro; Ōmura, Satoshi. A new peptide antibiotic KM-8. J. Antibiot. 28(10), 819–820 (1975).

• 27 Awaya, Juichi; Kesado, Tadataka; Ōmura, Satoshi; Lukacs, Gabor. Preparation of ¹³C- and ³H-labeled cerulenin and biosynthesis with ¹³C-NMR. J. Antibiot. 28(10), 824–827 (1975).

• 28 Tanaka, Haruo; Koyama, Yasuaki; Awaya, Juichi; Marumo, Hirofuto; Ōiwa, Ruiko; Katagiri, Michiko; Nagai, Toshiaki; Ōmura, Satoshi. Nanaomycins, new antibiotics produced by a strain of Streptomyces. I. Taxonomy, isolation, characterization and biological properties. J. Antibiot. 28(11), 860–867 (1975).

• 29 Tanaka, Haruo; Koyama, Yasuaki; Nagai, Toshiaki; Marumo, Hirofuto; Ōmura, Satoshi. Nanaomycins, new antibiotics produced by a strain of Streptomyces. II. Structure and biosynthesis. J. Antibiot. 28(11), 868–875 (1975).

• 30 Tanaka, Haruo; Marumo, Hirofuto; Nagai, Toshiaki; Okada, Masafumi; Taniguchi, Kazuyoshi; Ōmura, Satoshi. Nanaomycins, new antibiotics produced by a strain of Streptomyces. III. New component, nanaomycin C, and biological activities of nanaomycin derivatives. J. Antibiot. 28(12), 925–930 (1975).

• 31 Schwartz, Jeffrey L.; Tishler, Max; Arison, Byron H.; Shafer, Henry M.; Ōmura, Satoshi. Identification of mycolutein and pulvomycin as aureothin and labilomycin respectively. J. Antibiot. 29(3), 236–241 (1976).

• 32 Ōmura, Satoshi; Takeshima, Hideo; Nakagawa, Akira; Miyazawa, Jun. The biosynthesis of picromycin using ¹³C enriched precursors. J. Antibiot. 29(3), 316–317 (1976).

• 33 Ōmura, Satoshi; Nishikiori, Takaaki; Ōiwa, Ruiko; Iwai, Yuzuru; Masuma, Rokurou; Katagiri, Michiko. A new antibiotic KM-214 produced by a strain of Bacillus. J. Antibiot. 29(4), 477–478 (1976).

• 34 Ōmura, Satoshi; Iwai, Yuzuru; Suzuki,Yōko; Awaya, Juichi; Konda, Yaeko; Onda, Masayuki. Production of quinoline-2-methanol and quinoline-2-methanol acetate by a new species of Kitasatoa, Kitasatoa griseophaeus. J. Antibiot. 29(8), 797–803 (1976).

• 35 Ōmura, Satoshi; Kitao, Chiaki; Tanaka, Haruo; Ōiwa, Ruiko; Takahashi, Yoko; Nakagawa, Akira; Shimada, Masayuki; Iwai, Yuzuru. A new antibiotic, asukamycin, produced by Streptomyces. J. Antibiot. 29(9), 876–881 (1976).

• 36 Ōmura, Satoshi; Miyazawa, Jun; Takeshima, Hideo; Kitao, Chiaki; Atsumi, Kiyoo; Aizawa, Minoru. Bioconversion of leucomycins and its regulation by butyrate in a producing strain. J. Antibiot.29(10), 1131–1133 (1976).

• 37 Umezawa, Iwao; Komiyama, Kanki; Takeshima, Hideo; Awaya, Juichi; Ōmura, Satoshi. A new antitumor antibiotic, PO-357. J. Antibiot. 29(11), 1249–1251 (1976).

• 38 Ōmura, Satoshi; Miyazawa, Jun; Takeshima, Hideo; Kitao, Chiaki; Aizawa, Minoru. Induction of the bioconversion of leucomycins by glucose in a producing strain. J. Antibiot. 30(2), 192–193 (1977).

• 39 Ōmura, Satoshi; Iwai, Yuzuru; Hirano, Atsushi; Nakagawa, Akira; Awaya, Juichi; Tsuchiya, Hisae; Takahashi, Yoko; Masuma, Rokurou. A new alkaloid AM-2282 of Streptomyces origin. Taxonomy, fermentation, isolation and preliminary characterization. J. Antibiot. 30(4), 275–282 (1977).

• 40 Shimada, Masayuki; Honda, Hiroko; Awaya, Juichi; Ōmura, Satoshi. A new antibiotic, OS-1804. J. Antibiot. 30(4), 330–331 (1977).

• 41 Ōmura, Satoshi; Tanaka, Haruo; Ōiwa, Ruiko; Awaya, Juichi; Masuma, Rokurou; Tanaka, Katsumi. New antitumor antibiotics, OS-4742 A₁, A₂, B₁ and B₂ produced by a strain of Streptomyces. J. Antibiot. 30(11), 908–916 (1977).

• 42 Ōmura, Satoshi; Kitao, Chiaki; Miyazawa, Jun; Imai, Harumitsu; Takeshima, Hideo. Bioconversion and biosynthesis of 16-membered macrolide antibiotic, tylosin, using enzyme inhibitor: cerulenin. J. Antibiot. 31(3), 254–256 (1978).

• 43 Iwai, Yuzuru; Hirano, Atsushi; Awaya, Juichi; Matsuo, Shigetaka; Ōmura, Satoshi. 1,3-Diphenethylurea from Streptomyces sp. No. AM-2498. J. Antibiot. 31(4), 375–376 (1978).

• 44 Nishikiori, Takaaki; Masuma, Rokurou; Ōiwa, Ruiko; Katagiri, Michiko; Awaya, Juichi; Iwai, Yuzuru; Ōmura, Satoshi. Aurantinin, a new antibiotic of bacterial origin. J. Antibiot. 31(6), 525–532 (1978).

• 45 Iwai, Yuzuru; Kōra, Akiko; Takahashi, Yōko; Hayashi, Takako; Awaya, Juichi; Masuma, Rokurou; Ōiwa, Ruiko; Ōmura, Satoshi. Production of deoxyfrenolicin and a new antibiotic, frenolicin B by Streptomyces roseofulvus strain AM-3867. J. Antibiot. 31(10), 959–965 (1978).

• 46 Ōmura, Satoshi; Tanaka, Haruo; Iwai, Yuzuru; Nishigaki, Kazue; Awaya, Juichi; Takahashi, Yōko; Masuma, Rokurou. A new antibiotic, Setomimycin, produced by a strain of Streptomyces. J. Antibiot. 31(11), 1091–1098 (1978).

• 47 Ohno, Hiroie; Saheki, Tsuneo; Awaya, Juichi; Nakagawa, Akira; Ōmura, Satoshi. Isolation and characterization of elasnin, a new human granulocyte elastase inhibitor produced by a strain of Streptomyces. J. Antibiot. 31(11), 1116–1123 (1978).

• 48 Ōmura, Satoshi; Iwai, Yuzuru; Takahashi, Yōko; Sadakane, Noriaki; Nakagawa, Akira; Ōiwa, Hitoshi; Hasegawa, Yasuhiro; Ikai, Takashi. Herbimycin, a new antibiotic produced by a strain of Streptomyces. J. Antibiot. 32(4), 255–261 (1979).

• 49 Okubo, Shuji; Nakamura, Nobuo; Ito, Kunio; Marumo, Hirofuto; Tanaka, Masao; Ōmura, Satoshi. Antitumor activity of prumycin. J. Antibiot. 32(4), 347–354 (1979).

• 50 Kasai, Masaji; Shirahata, Kunikatsu; Ishii, Shinzo; Mineura, Kazuyuki; Marumo, Hirofuto; Tanaka, Haruo; Ōmura, Satoshi. Structure of nanaomycin E, a new nanaomycin. J. Antibiot. 32(5), 442–425 (1979).

• 51 Kitao, Chiaki; Ikeda, Haruo; Hamada, Hidetaka; Ōmura, Satoshi. Bioconversion and biosynthesis of 16-membered macrolide antibiotics. XIII. Regulation of spiramycin I 3-hydroxyl acylase formation by glucose, butyrate, and cerulenin. J. Antibiot. 32(6), 593–599 (1979).

• 52 Hirano, Atsushi; Iwai, Yuzuru; Masuma, Rokurou; Tei, Kiyoizumi; Ōmura, Satoshi. Neoxaline, a new alkaloid produced by Aspergillus japonicus. Production, isolation and properties. J. Antibiot. 32(8), 781–785 (1979).

• 53 Ōmura, Satoshi; Hirano, Atsushi; Iwai, Yuzuru; Masuma, Rokurou. Herquline, a new alkaloid produced by Penicillium herquei. Fermentation, isolation and properties. J. Antibiot. 32(8), 786–790 (1979).

• 54 Ōmura, Satoshi; Tanaka, Haruo; Ōiwa, Ruiko; Nagai, Toshiaki; Koyama, Yasuaki; Takahashi, Yoko. Studies on bacterial cell wall inhibitors. VI. Screening method for the specific inhibitors of peptidoglycan synthesis. J. Antibiot. 32(10), 978–984 (1979).

• 55 Ōmura, Satoshi; Tanaka, Haruo; Tanaka, Yoshitake; Spiri-Nakagawa, Priska; Ōiwa, Ruiko; Takahashi, Yoko; Matsuyama, Kyoko; Iwai, Yuzuru. Studies on bacterial cell wall inhibitors. VII. Azureomycins A and B, new antibiotics produced by Pseudonocardia azurea species nova. Taxonomy of the producing organism, isolation, characterization and biological properties. J. Antibiot. 32(10), 985–994 (1979).

• 56 Spiri-Nakagawa, Priska; Tanaka, Yoshitake; Ōiwa, Ruiko; Tanaka, Haruo; Ōmura, Satoshi. Studies on bacterial cell wall inhibitors. VIII. Mode of action of a new antibiotic, azureomycin B, in Bacillus cereus T. J. Antibiot. 32(10), 995–1001 (1979).

• 57 Awaya, Juichi; Matsuyama, Kyoko; Iwai, Yuzuru; Ōmura, Satoshi; Ōiwa, Hitoshi; Hasegawa, Yasuhiro; Ikai, Takashi. Production of 9-β-D-arabinofuranosyladenine by a new species of Streptomyces and its herbicidal activity. J. Antibiot. 32(10), 1050–1054 (1979).

• 58 Kitao, Chiaki; Hamada, Hidetaka; Ikeda, Haruo; Ōmura, Satoshi. Bioconversion and biosynthesis of 16-membered macrolide antibiotics. XV. Final steps in the biosynthesis of leucomycins. J. Antibiot. 32(10), 1055–1057 (1979).

• 59 Ōmura, Satoshi; Ikeda, Haruo; Kitao, Chiaki. The detection of a plasmid in Streptomyces ambofaciens KA-1028 and its possible involvement in spiramycin production. J. Antibiot. 32(10), 1058–1060 (1979).

• 60 Iwai, Yuzuru; Nakagawa, Akira; Nagai, Akiko; Matsuyama, Kyoko; Takahashi, Yoko; Yamashita, Mariko; Hirano, Atsushi; Ōmura, Satoshi. 2'-Amino-2'-deoxyadenosine produced by a strain of Actinomadura. J. Antibiot. 32(12), 1367–1369 (1979).

• 61 Okubo, Shuji; Nakamura, Nobuo; Morimoto, Makoto; Mineura, Kazuyuki; Marumo, Hirofuto; Ōmura, Satoshi. Studies on antitumor activity of prumycin. II. Studies on distribution and excretion of prumycin. J. Antibiot. 33(2), 221–225 (1980).

• 62 Okubo, Shuji; Nakamura, Nobuo; Morimoto, Makoto; Mineura, Kazuyuki; Marumo, Hirofuto; Ōmura, Satoshi. Studies on antitumor activity of prumycin. III. Mode of action of prumycin on HeLa S-3 cells. J. Antibiot. 33(2), 226–230 (1980).

• 63 Okubo, Shuji; Morimoto, Makoto; Mineura, Kazuyuki; Marumo, Hirofuto; Ōmura, Satoshi. Studies on antitumor activity of prumycin. IV. Effect of prumycin on mouse immune system. J. Antibiot. 33(2), 231–235 (1980).

• 64 Ohno, Hiroie; Yoshida, Masakazu; Takahashi, Yoko; Ōmura, Satoshi. Improvement of the productivity of elasnin, a specific elastase inhibitor, by Streptomyces noboritoensis KM-2753. J. Antibiot. 33(5), 474–479 (1980).

• 65 Kitao, Chiaki; Tanaka, Haruo; Minami, Shizuko; Ōmura, Satoshi. Bioconversion and biosynthesis of nanaomycins using cerulenin, a specific inhibitor of fatty acid and polyketide biosynthesis. J. Antibiot. 33(7), 711–716 (1980).

• 66 Ōmura, Satoshi; Iwai, Yuzuru; Masuma, Rokurou; Hayashi, Mamoru; Furusato, Takashi; Takagaki, Tatsuo. A new peptide antibiotic, alboleutin. J. Antibiot. 33(7), 758–759 (1980).

• 67 Furusaki, Akio; Matsumoto, Takeshi; Nakagawa, Akira; Ōmura, Satoshi. Herbimycin A. an ansamycin antibiotic; X-ray crystal structure. J. Antibiot. 33(7), 781–782 (1980).

• 68 Marumo, Hirofuto; Kitaura, Kozo; Morimoto, Makoto; Tanaka, Haruo; Ōmura, Satoshi. The mode of action of nanaomycin A in gram-positive bacteria. J. Antibiot. 33(8), 885–890 (1980).

• 69 Ōmura, Satoshi; Kitao, Chiaki; Sadakane, Noriaki. The microbial transformation of tylosin by the spiramycin-producing strain, Streptomyces ambofaciens KA-1028. J. Antibiot. 33(8), 911–912 (1980).

• 70 Ōmura, Satoshi; Sadakane, Noriaki; Kitao, Chiaki; Matsubara, Hajime; Nakagawa, Akira. Production of mycarosyl protylonolide by a mycaminose idiotroph from the tylosin-producing strain Streptomyces fradiae KA-427. J. Antibiot. 33(8), 913–914 (1980).

• 71 Ōmura, Satoshi; Matsubara, Hajime; Nakagawa, Akira; Furusaki, Akio; Matsumoto, Takeshi. X-ray crystallography of protylonolide and absolute configuration of tylosin. J. Antibiot. 33(8), 915–917 (1980).

• 72 Iwai, Yuzuru; Nakagawa, Akira; Sadakane, Noriaki; Ōmura, Satoshi; Ōiwa, Hitoshi; Matsumoto, Shinichi; Takahashi, Masao; Ikai, Takashi; Ochiai, Yoshinori. Herbimycin B, a new benzoquinonoid ansamycin with anti-tobacco mosaic virus (-TMV) and herbicidal activities. J. Antibiot. 33(10), 1114–1119 (1980).

• 73 Ōmura, Satoshi; Nakagawa, Akira; Hashimoto, Hiroshi; Ōiwa, Ruiko; Iwai, Yuzuru; Hirano, Atsushi; Shibukawa, Nobuyuki; Kojima, Yasuhiko. Virantmycin, a potent antiviral antibiotic produced by a strain of Streptomyces. J. Antibiot. 33(11), 1395–1396 (1980).

• 74 Ōmura, Satoshi; Tanaka, Yoshitake; Tanaka, Haruo; Takahashi, Yoko; Iwai, Yuzuru. Stimulation of the production of macrolide antibiotics by magnesium phosphate and related insoluble materials. J. Antibiot.33 (12), 1568–1569 (1980).

• 75 Ōmura, Satoshi; Ikeda, Haruo; Matsubara, Hajime; Sadakane, Noriaki. Hybrid biosynthesis and absolute configuration of macrolide antibiotic M-4365 G₁. J. Antibiot. 33(12), 1570–1572 (1980).

• 76 Taguchi, Fumiaki; Imatani, Yoshiko; Nagaki, Daizo; Nakagawa, Akira; Ōmura, Satoshi. Selective antiviral activity of the antibiotic 2'-amino-2'-deoxyribofuranosyl adenine. J. Antibiot. 34(3), 313–316 (1981).

• 77 Ōmura, Satoshi; Ikeda, Haruo; Tanaka, Haruo. Extraction and characterization of plasmids from macrolide antibiotic-producing streptomycetes. J. Antibiot. 34(4), 478–482 (1981).

• 78 Sakakibara, Hideo; Okekawa, Osamu; Fujiwara, Tatsuro; Otani, Masaru; Ōmura, Satoshi. Acyl derivatives of 16-membered macrolides. I. Synthesis and biological properties of 3"-O-propionylleucomycin A₅ (TMS-19-Q). J. Antibiot. 34(8), 1001–1010 (1981).

• 79 Sakakibara, Hideo; Okekawa, Osamu; Fujiwara, Tatsuro; Aizawa, Minoru; Ōmura, Satoshi. Acyl derivatives of 16-membered macrolides. II. Antibacterial activities and serum levels of 3"-O-acyl derivatives of leucomycin. J. Antibiot. 34(8), 1011–1018 (1981).

• 80 Konda, Yaeko; Onda, Masayuki; Hinotozawa, Kiyoizumi; Ōmura, Satoshi. Structure of antitumor alkaloid AM–6201. J. Antibiot. 34(9), 1222–1223 (1981).

• 81 Ōmura, Satoshi; Otoguro, Kazuhiko; Nishikiori, Takaaki; Ōiwa, Ruiko; Iwai, Yuzuru. Setamycin, a new antibiotic. J. Antibiot. 34(10), 1253–1256 (1981).

• 82 Nakagawa, Akira; Iwai, Yuzuru; Hashimoto, Hiroshi; Miyazaki, Nobuko; Ōiwa, Ruiko; Takahashi, Yoko; Hirano, Atsushi; Shibukawa, Nobuyuki; Kojima, Yasuhiko; Ōmura, Satoshi. Virantmycin, a new antiviral antibiotic produced by a strain of Streptomyces. J. Antibiot. 34 (11), 1408–1415 (1981).

• 83 Imamura, Nobutaka; Kakinuma, Katsumi; Ikekawa, Nobuo; Tanaka, Haruo; Ōmura, Satoshi. The structure of vineomycin B₂. J. Antibiot. 34(11), 1517–1518 (1981).

• 84 Sakakibara, Hideo; Fujiwara, Tatsuro; Aizawa, Minoru; Ōmura, Satoshi. 9-epi-Leucomycin A₅. Synthesis and antimicrobial activity. J. Antibiot. 34(12), 1577–1580 (1981).

• 85 Ōmura, Satoshi; Iwai, Yuzuru; Takahashi, Yoko; Kojima, Kazuko; Otoguro, Kazuhiko; Ōiwa, Ruiko. Type of diaminopimelic acid different in aerial and vegetative mycelia of setamycin-producing actinomycete KM-6054. J. Antibiot. 34(12), 1633–1634 (1981).

• 86 Iwai, Yuzuru; Ōmura, Satoshi. Culture conditions for screening of new antibiotics. J. Antibiot. 35(2), 123–141 (1982).

• 87 Ōmura, Satoshi; Tanaka, Yoshitake; Nakagawa, Akira; Iwai, Yuzuru; Inoue, Masaharu; Tanaka, Haruo. Irumamycin, a new antibiotic active against phytopathogenic fungi. J. Antibiot. 35(2), 256–257 (1982).

• 88 Ōmura, Satoshi; Tanaka, Haruo; Inokoshi, Junji; Sakakibara, Hideo; Fujiwara, Tatsuro. Binding of [³H]tetrahydroleucomycin A₃ to Escherichia coli ribosomes and the effect of 3''-O-acyl derivatives of leucomycins on the binding. J. Antibiot. 35(4), 491–496 (1982).

• 89 Ikeda, Haruo; Tanaka, Haruo; Ōmura, Satoshi. Isolation and characterization of covalently closed circular DNA associated with chromosomal and membrane fraction from Streptomyces ambofaciens. J. Antibiot. 35(4), 497–506 (1982).

• 90 Ikeda, Haruo; Tanaka, Haruo; Ōmura, Satoshi. Genetic and biochemical features of spiramycin biosynthesis in Streptomyces ambofaciens. Curing, protoplast regeneration and plasmid transfer. J. Antibiot. 35(4), 507–516 (1982).

• 91 Imamura, Nobutaka; Kakinuma, Katsumi; Ikekawa, Nobuo; Tanaka, Haruo; Ōmura, Satoshi. Biosynthesis of vineomycins A₁ and B₂. J. Antibiot. 35(5), 602–608 (1982).

• 92 Ōmura, Satoshi; Iwai, Yuzuru; Hinotozawa, Kiyoizumi; Takahashi, Yoko; Kato, Junko; Nakagawa, Akira; Hirano, Atsushi; Shimizu, Hideki; Haneda, Katsuji. Cervinomycin A1 and A2, new antibiotics active against anaerobes, produced by Streptomyces cervinus sp. nov. J. Antibiot. 35(6), 645–652 (1982).

• 93 Sadakane, Noriaki; Tanaka, Yoshitake; Ōmura, Satoshi. Hybrid biosynthesis of derivatives of protylonolide and M-4365 by macrolide-producing microorganisms. J. Antibiot. 35(6), 680–687 (1982).

• 94 Ōmura, Satoshi; Takahashi, Yōko; Iwai, Yuzuru; Tanaka, Haruo. Kitasatosporia, a new genus of the order Actinomycetales. J. Antibiot. 35(8), 1013–1019 (1982).

• 95 Hayashi, Maki; Unemoto, Tsutomu; Minami-Kakinuma, Shizuko; Tanaka, Haruo; Ōmura, Satoshi. The mode of action of nanaomycins D and A on a gram-negative marine bacterium Vibrio alginolyticus. J. Antibiot. 35(8), 1078–1085 (1982).

• 96 Masuma, Rokurou; Tanaka, Yoshitake; Ōmura, Satoshi. Enhancement of cerulenin production by a natural zeolite, an ammonium ion-trapping agent. J. Antibiot. 35(9), 1184–1193 (1982).

• 97 Tanaka, Haruo; Ōiwa, Ruiko; Matsukura, Shigekazu; Inokoshi, Junji; Ōmura, Satoshi. Studies on bacterial cell wall inhibitors. X. Properties of phosphor-N-acetylmuramoylpentapeptide transferase in peptidoglycan synthesis of Bacillus megaterium and its inhibition by amphomycin. J. Antibiot. 35(9), 1216–1221 (1982).

• 98 Ōmura, Satoshi; Iwai, Yuzuru; Hinotozawa, Kiyoizumi; Tanaka, Haruo; Takahashi, Yoko; Nakagawa, Akira. OM-704 A, a new antibiotic active against gram-positive bacteria produced by Streptomyces sp. J. Antibiot. 35(11), 1425–1429 (1982).

• 99 Tanaka, Haruo; Minami-Kakinuma, Shizuko; Ōmura, Satoshi. Biosynthesis of nanaomycin. III. Nanaomycin A formation from nanaomycin D by nanaomycin D reductase via a hydroquinone. J. Antibiot. 35(11), 1565–1570 (1982).

• 100 Ōmura, Satoshi; Shimizu, Hideki; Iwai, Yuzuru; Hinotozawa, Kiyoizumi; Otoguro, Kazuhiko; Hashimoto, Hiroshi; Nakagawa, Akira. AM-2604 A, a new antiviral antibiotic produced by a strain of Streptomyces. J. Antibiot. 35 (12), 1632–1637 (1982).

• 101 Ōmura, Satoshi; Iwai, Yuzuru; Nakagawa, Akira; Iwata, Rimiko; Takahashi, Yoko; Shimizu, Hideki; Tanaka, Haruo. Thiotetromycin, a new antibiotic. Taxonomy, production, isolation, and physicochemical and biological properties. J. Antibiot. 36(2), 109–114 (1983).

• 102 Ikeda, Haruo; Inoue, Masaharu; Ōmura, Satoshi. Improvement of macrolide antibiotic-producing streptomycete strains by the regeneration of protoplasts. J. Antibiot. 36(3), 283–288 (1983).

• 103 Ōmura, Satoshi; Tsuzuki, Kazuo; Nakagawa, Akira; Lukacs, Gabor. Biosynthetic origin of carbons 3 and 4 of leucomycin aglycone. J. Antibiot. 36(5), 611–613 (1983).

• 104 Ōmura, Satoshi; Tsuzuki, Kazuo; Tanaka, Yoshitake; Sakakibara, Hideo; Aizawa, Minoru; Lukacs, Gabor. Valine as a precursor of n -butyrate unit in the biosynthesis of macrolide aglycone. J. Antibiot. 36(5), 614–616 (1983).

• 105 Sadakane, Noriaki; Tanaka, Yoshitake; Ōmura, Satoshi. Hybrid biosynthesis of a new macrolide antibiotic by a daunomycin-producing microorganism. J. Antibiot. 36(7), 921–922 (1983).

• 106 Ōmura, Satoshi; Sadakane, Noriaki; Tanaka, Yoshitake; Matsubara, Hajime. Chimeramycins: new macrolide antibiotics produced by hybrid biosynthesis. J. Antibiot. 36(7), 927–930 (1983).

• 107 Sadakane, Noriaki; Tanaka, Yoshitake; Ōmura, Satoshi. New 20-membered lactones, irumanolides I and II, produced by a mutant of Streptomyces. J. Antibiot. 36(7), 931–933 (1983).

• 108 Ōmura, Satoshi; Nakagawa, Akira; Aoyama, Hiroshi; Iwai, Yuzuru; Kuwahara, Masao; Furusato, Takashi. Karabemycin, a new antimetabolite of glutamine produced by a strain of streptomycete. J. Antibiot. 36(9), 1129–1135 (1983).

• 109 Iwai, Yuzuru; Kimura, Keiko; Takahashi, Yōko; Hinotozawa, Kiyoizumi; Shimizu, Hideki; Tanaka, Haruo; Ōmura, Satoshi. OM-173, new nanaomycin-type antibiotics produced by a strain of Streptomyces. Taxonomy, production, isolation and biological properties. J. Antibiot. 36(10), 1268–1274 (1983).

• 110 Sano, Hiroshi; Inoue, Michi; Yamashita, Kinya; Okachi, Ryo; Ōmura, Satoshi. Chemical modification of spiramycins. I. Synthesis of the acetal derivatives of neospiramycin I. J. Antibiot. 36(10), 1336–1344 (1983).

• 111 Tsuzuki, Kazuo; Ōmura, Satoshi. Syntheses and biological activities of thiotetromycin analogs. J. Antibiot. 36(11), 1589–1591 (1983).

• 112 Ōmura, Satoshi; Inokoshi, Junji; Matsubara, Hajime; Tanaka, Haruo. Ribosome-binding activities and antimicrobial activities of tylosin and its related compounds. J. Antibiot. 36(12), 1709–1712 (1983).

• 113 Matsubara, Hajime; Inokoshi, Junji; Nakagawa, Akira; Tanaka, Haruo; Ōmura, Satoshi. Chemical modification of tylosin: synthesis of amino derivatives at C–20 position of tylosin and demycarosyltylosin. J. Antibiot. 36(12), 1713–1721 (1983).

• 114 Ōmura, Satoshi; Otoguro, Kazuhiko; Tanaka, Haruo. The mode of action of a novel 18-membered macrolide, virustomycin A (AM-2604 A), on Trichomonas foetus. J. Antibiot. 36(12), 1755–1761 (1983).

• 115 Ōmura, Satoshi; Nakagawa, Akira; Iwata, Rimiko; Hatano, Akiko. Structure of a new antibacterial antibiotic, thiotetromycin. J. Antibiot. 36(12), 1781–1782 (1983).

• 116 Ōmura, Satoshi; Imamura, Nobutaka; Hinotozawa, Kiyoizumi; Otoguro, Kazuhiko; Lukacs, Gabor; Faghih, Ramine; Tolmann, Richard; Arison, Byron H.; Smith, Jack L. The structure of virustomycin A. J. Antibiot. 36(12), 1783–1786 (1983).

• 117 Ōmura, Satoshi; Tanaka, Yoshitake; Mamada, Hiroshi; Masuma, Rokurō. Ammonium ion suppresses the biosynthesis of tylosin aglycone by interference with valine catabolism in Streptomyces fradiae. J. Antibiot. 36(12), 1792–1794 (1983).

• 118 Ōmura, Satoshi; Tanaka, Yoshitake; Mamada, Hiroshi; Masuma, Rokuro. Effect of ammonium ion, inorganic phosphate and amino acids on the biosynthesis of protylonolide, a precursor of tylosin aglycon. J. Antibiot. 37(5), 494–502 (1984).

• 119 Ōmura, Satoshi; Mamada, Hiroshi; Wang, Nanjin; Imamura, Nobutaka; Ōiwa, Ruiko; Iwai, Yuzuru; Muto, Naoki. Takaokamycin, a new peptide antibiotic produced by Streptomyces sp. J. Antibiot. 37(7), 700–705 (1984).

• 120 Sano, Hiroshi; Inoue, Michi; Ōmura, Satoshi. Chemical modification of spiramycins. II. Synthesis and antimicrobial activity of 4'-deoxy derivatives of neospiramycin I and their 12-(Z)-isomers. J. Antibiot. 37(7), 738–749 (1984).

• 121 Sano, Hiroshi; Sunazuka, Toshiaki; Tanaka, Haruo; Yamashita, Kinya; Okachi, Ryo; Ōmura, Satoshi. Chemical modification of spiramycins. III. Synthesis and antibacterial activities of 4"-sulfonates and 4"-alkylethers of spiramycin I. J. Antibiot. 37(7), 750–759 (1984).

• 122 Sano, Hiroshi; Sunazuka, Toshiaki; Tanaka, Haruo; Yamashita, Kinya; Okachi, Ryo; Ōmura, Satoshi. Chemical modification of spiramycins. IV. Synthesis and in vitro and in vivo activities of 3",4"-diacylates and 3,3",4"-triacylates of spiramycin I. J. Antibiot. 37(7), 760–772 (1984).

• 123 Ōmura, Satoshi; Murata, Masatsune; Hanaki, Hideaki; Hinotozawa, Kiyoizumi; Ōiwa, Ruiko; Tanaka, Haruo. Phosalacine, a new herbicidal antibiotic containing phosphinothricin. Fermentation, isolation, biological activity and mechanism of action. J. Antibiot. 37(8), 829–835 (1984).

• 124 Ōmura, Satoshi; Hinotozawa, Kiyoizumi; Imamura, Nobutaka; Murata, Masatsune. The structure of phosalacine, a new herbicidal antibiotic containing phosphinothricin. J. Antibiot. 37(8), 939–940 (1984).

• 125 Ōmura, Satoshi; Matsubara, Hajime; Tsuzuki, Kazuo; Nakagawa, Akira. Chemical modification of tylosin. Thioether derivatives of tylosin and demycarosyltylosin. J. Antibiot. 37(9), 1007–1015 (1984).

• 126 Ikeda, Haruo; Inoue, Masaharu; Tanaka, Haruo; Ōmura, Satoshi. Interspecific protoplast fusion among macrolide-producing streptomycetes. J. Antibiot. 37(10), 1224–1230 (1984).

• 127 Ōmura, Satoshi; Miyano, Katsuji; Nakagawa, Akira; Sano, Hiroshi; Komiyama, Kanki; Umezawa, Iwao; Shibata, Kiyoshi; Satsumabayashi, Sadayoshi. Chemical modification and antitumor activity of herbimycin A.8,9-epoxide, 7,9-cyclic carbamate and 17 or 19-amino derivatives. J. Antibiot. 37(10), 1264–1267 (1984).

• 128 Ōmura, Satoshi; Murata, Masatsune; Imamura, Nobutaka; Iwai, Yuzuru; Tanaka, Haruo; Furusaki, Akio; Matsumoto, Takeshi. Oxetin, a new antimetabolite from an actinomycete. Fermentation, isolation, structure and biological activity. J. Antibiot. 37(11), 1324–1332 (1984).

• 129 Ōmura, Satoshi; Taki, Arihiro; Matsuda, Kazuko; Tanaka, Yoshitake. Ammonium ions suppress the amino acid metabolism involved in the biosynthesis of protylonolide in a mutant of Streptomyces fradiae. J. Antibiot. 37(11), 1362–1369 (1984).

• 130 Tanaka, Yoshitake; Masuma, Rokuro; Ōmura, Satoshi. Control of ammonium ion level for efficient nanaomycin production. J. Antibiot. 37(11), 1370–1375 (1984).

• 131 Ōmura, Satoshi; Tanaka, Yoshitake; Takahashi, Yoko; Chia, Iri; Inoue, Masaharu; Iwai, Yuzuru. Irumamycin, an antifungal 20-membered macrolide produced by a Streptomyces. Taxonomy, fermentation and biological properties. J. Antibiot. 37(12), 1572–1578 (1984).

• 132 Sano, Hiroshi; Tanaka, Haruo; Yamashita, Kinya; Okachi, Ryo; Ōmura, Satoshi. Chemical modification of spiramycins. V. Synthesis and antibacterial activity of 3'- or 4'''-de- N -methylspiramycin I and their N -substituted derivatives. J. Antibiot. 38(2), 186–196 (1985).

• 133 Ōmura, Satoshi; Nakagawa, Akira; Imamura, Nobutaka; Kushida, Katsuhiko; Liu, Chao Min; Sello, Lilian H.; Westley, John W. Structure of a new macrolide antibiotic, X–14952B. J. Antibiot. 38(5), 674–676 (1985).

• 134 Ōmura, Satoshi; Imamura, Nobutaka; Kuga, Hiroshi; Ishikawa, Hideyo; Yamazaki, Yukiko; Okano, Keiko; Kimura, Keiko; Takahashi, Yoko; Tanaka, Haruo. Adechlorin, a new adenosine deaminase inhibitor containing chlorine. Production, isolation and properties. J. Antibiot. 38(8), 1008–1015 (1985).

• 135 Ōmura, Satoshi; Murata, Masatsune; Kimura, Keiko; Matsukura, Shigekazu; Nishihara, Tatsuro; Tanaka, Haruo. Screening for new antifolates of microbial origin and a new antifolate AM-8402. J. Antibiot. 38(8), 1016–1024 (1985).

• 136 Murata, Masatsune; Miyasaka, Toyoko; Tanaka, Haruo; Ōmura, Satoshi. Diazaquinomycin A, a new antifolate antibiotic, inhibits thymidylate synthase. J. Antibiot. 38(8), 1025–1033 (1985).

• 137 Imamura, Nobutaka; Murata, Masatsune; Yao, Tianjue; Ōiwa, Ruiko; Tanaka, Haruo; Ōmura, Satoshi. Occurrence of 1,2,4-triazole ring in actinomycetes. J. Antibiot. 38(8), 1110–1111 (1985).

• 138 Nakagawa, Akira; Tomoda, Hiroshi; Hao, Mai Van; Okano, Keiko; Iwai, Yuzuru; Ōmura, Satoshi. Antiviral activities of pentalenolactones. J. Antibiot. 38(8), 1114–1115 (1985).

• 139 Nakagawa, Akira; Tanaka, Yoshitake; Otoguro, Kazuhiko; Ōmura, Satoshi; Takiguchi, Toshimitsu; Arai, Yuko. A new antifungal antibiotic, 3'-O-decarbamoylirumamycin. J. Antibiot. 38(9), 1266–1269 (1985).

• 140 Ōmura, Satoshi; Iwata, Rimiko; Iwai, Yuzuru; Taga, Seiko; Tanaka, Yoshitake; Tomoda, Hiroshi. Luminamicin, a new antibiotic. Production, isolation and physico-chemical and biological properties. J. Antibiot. 38(10), 1322–1326 (1985).

• 141 Sano, Hiroshi; Sunazuka, Toshiaki; Tanaka, Haruo; Yamashita, Kinya; Okachi, Ryo; Ōmura, Satoshi. Chemical modification of spiramycins. VI. Synthesis and antibacterial activities of 3,3"-di- O -acyl-4"- O -sulfonyl and 3,3"-di- O -acyl-4"- O -alkyl derivatives of spiramycin I. J. Antibiot. 38(10), 1350–1358 (1985).

• 142 Ōmura, Satoshi; Tsuzuki, Kazuo; Iwai, Yuzuru; Kishi, Masanori; Watanabe, Shiro; Shimizu, Hideki. Anticoccidial activity of frenolicin B and its derivatives. J. Antibiot. 38(10), 1447–1448 (1985).

• 143 Ōmura, Satoshi; Tsuzuki, Kazuo; Sunazuka, Toshiaki; Toyota, Hajime; Takahashi, Itsuo; Itoh, Zen. Gastrointestinal motor-stimulating activity of macrolide antibiotics and the structure-activity relationship. J. Antibiot. 38(11), 1631–1632 (1985).

• 144 Ōmura, Satoshi; Tanaka, Haruo; Kuga, Hiroshi; Imamura, Nobutaka. Adecypenol, a unique adenosine deaminase inhibitor containing homopurine and cyclopentene rings. J. Antibiot. 39(2), 309–310 (1986).

• 145 Shibata, Kiyoshi; Satsumabayashi, Sadayoshi; Sano, Hiroshi; Komiyama, Kanki; Nakagawa, Akira; Ōmura, Satoshi. Chemical modification of herbimycin A. Synthesis and in vivo antitumor activities of halogenated and other related derivatives of herbimycin A. J. Antibiot. 39(3), 415–423 (1986).

• 146 Tanaka, Yoshitake; Taki, Arihiro; Masuma, Rokuro; Ōmura, Satoshi. Mechanism of nitrogen regulation of protylonolide biosynthesis in Streptomyces fradiae. J. Antibiot. 39(6), 813–821 (1986).

• 147 Ōmura, Satoshi; Imamura, Nobutaka; Kawakita, Kazuhito; Mori, Yoko; Yamazaki, Yukiko; Masuma, Rokurou; Takahashi, Yōko; Tanaka, Haruo; Huang, Lee Yuan; Woodruff, H. Boyd. Ahpatinins, new acid protease inhibitors containing 4-amino-3-hydroxy-5-phenylpentanoic acid. J. Antibiot. 39(8), 1079–1085 (1986).

• 148 Ōmura, Satoshi; Nakagawa, Akira; Fukamachi, Nobuko; Otoguro, Kazuhiko; Kobayashi, Bonro. Aggreceride, a new platelet aggregation inhibitor from Streptomyces. J. Antibiot. 39(8), 1180–1181 (1986).

• 149 Tomoda, Hiroshi; Iwata, Rimiko; Takahashi, Yōko; Iwai, Yuzuru; Ōiwa, Ruiko; Ōmura, Satoshi. Lustromycin, a new antibiotic produced by Streptomyces sp. J. Antibiot. 39(9), 1205–1210 (1986).

• 150 Ōmura, Satoshi; Tomoda, Hiroshi; Xu, Qinmin; Takahashi, Yoko; Iwai, Yuzuru. Triacsins, new inhibitors of acyl-CoA synthetase produced by Streptomyces sp. J. Antibiot. 39(9), 1211–1218 (1986).

• 151 Ōmura, Satoshi; Ishikawa, Hideyo; Kuga, Hiroshi; Imamura, Nobutaka; Taga, Seiko; Takahashi, Yōko; Tanaka, Haruo. Adecypenol, a unique adenosine deaminase inhibitor containing homopurine and cyclopentene rings. Taxonomy, production and enzyme inhibition. J. Antibiot. 39(9), 1219–1224 (1986).

• 152 Tsuzuki, Kazuo; Iwai, Yuzuru; Ōmura, Satoshi; Shimizu, Hideki; Kitajima, Nakao. Nanaomycins production by a frenolicin B-producing strain. J. Antibiot. 39(9), 1343–1345 (1986).

• 153 Ōmura, Satoshi; Imamura, Nobutaka; Ōiwa, Ruiko; Kuga, Hiroshi; Iwata, Rimiko; Masuma, Rokuro; Iwai, Yuzuru. Clostomicins, new antibiotics produced by Micromonospora echinospora subsp. armeniaca subsp. nov. I. Production, isolation, and physicochemical and biological properties. J. Antibiot. 39(10), 1407–1412 (1986).

• 154 Takahashi, Yoko; Iwai, Yuzuru; Ōmura, Satoshi. Clostomicins, new antibiotics produced by Micromonospora echinospora subsp. armeniaca subsp. nov. II. Taxonomic study of the producing microorganism. J. Antibiot. 39(10), 1413–1418 (1986).

• 155 Masuma, Rokuro; Tanaka, Yoshitake; Tanaka, Hajime; Ōmura, Satoshi. Production of nanaomycin and other antibiotics by phosphate-depressed fermentation using phosphate-trapping agents. J. Antibiot. 39(11), 1557–1564 (1986).

• 156 Shibata, Kiyoshi; Satsumabayashi, Sadayoshi; Nakagawa, Akira; Ōmura, Satoshi. The structure and cytocidal activity of herbimycin C. J. Antibiot. 39(11), 1630–1633 (1986).

• 157 Nakagawa, Akira; Iwai, Yuzuru; Shimizu, Hideki; Ōmura, Satoshi. Enhanced antimicrobial activity of acetyl derivatives of cervinomycin. J. Antibiot. 39(11), 1636–1638 (1986).

• 158 Spiri-Nakagawa, Priska; Fukushi, Yukiko; Maebashi, Kazunori; Imamura, Nobutaka; Takahashi, Yoko; Tanaka, Yoshitake; Tanaka, Haruo; Ōmura, Satoshi. Izupeptins A and B, new glycopeptide antibiotics produced by an actinomycete. J. Antibiot. 39(12), 1719–1723 (1986).

• 159 Tsuzuki, Kazuo; Matsubara, Hajime; Nakagawa, Akira; Ōmura, Satoshi. Syntheses and antimicrobial activities of 9- O -acyl derivatives of tylosin and demycarosyltylosin. J. Antibiot. 39(12) 1784–1787 (1986).

• 160 Tanaka, Yoshitake; Hirata, Kazuko; Takahashi, Yoko; Iwai, Yuzuru; Ōmura, Satoshi. Globopeptin, a new antifungal peptide antibiotic. J. Antibiot. 40(2), 242–244 (1987).

• 161 Murata, Masatsune; Tanaka, Haruo; Ōmura, Satoshi. 7-Hydro-8-methylpteroylglutamylglutamic acid, a new antifolate from an actinomycete. Fermentation, isolation, structure, and biological activity. J. Antibiot. 40(3), 251–257 (1987).

• 162 Nakagawa, Akira; Ōmura, Satoshi; Kushida, Katsuhiko; Shimizu, Hideki; Lukacs, Gabor. Structure of cervinomycin, a novel xanthone antibiotic active against anaerobes and Mycoplasma. J. Antibiot. 40(3), 301–308 (1987).

• 163 Ōmura, Satoshi; Otoguro, Kazuhiko; Imamura, Nobutaka; Kuga, Hiroshi; Takahashi, Yoko; Masuma, Rokuro; Tanaka, Yoshitake; Tanaka, Haruo; Su, Xuehui; You, Entai. Jietacins A and B, new nematocidal antibiotics from a Streptomyces sp. Taxonomy, isolation, and physicochemical and biological properties. J. Antibiot. 40(5), 623–629 (1987).

• 164 Nakagawa, Akira; Fukamachi, Nobuko; Yamaki, Koji; Hayashi, Masahiko; Ohishi, Sachiko; Kobayashi, Bonro; Ōmura, Satoshi. Inhibition of platelet aggregation by medermycin and its related isochromanequinone antibiotics. J. Antibiot. 40(7), 1075–1076 (1987).

• 165 Ōmura, Satoshi; Tomoda, Hiroshi; Kumagai, Hidetoshi. Potent inhibitory effect of antibiotic 1233A on cholesterol biosynthesis which specifically blocks 3-hydroxy-3-methylglutaryl coenzyme a synthase. J. Antibiot. 40(9), 1356–1357 (1987).

• 166 Tomoda, Hiroshi; Igarashi, Kazuaki; Tanaka, Yoshitake; Ōmura, Satoshi. Biosynthetic preparation of labeled cerulenin with high specific radioactivity. J. Antibiot. 40(10), 1457–1460 (1987).

• 167 Ōmura, Satoshi; Nakagawa, Akira; Fujimoto, Tomoko; Saito, Kazunori; Otoguro, Kazuhiko; Walsh, James C. Hygromycin A, an antitreponemal substance. I. Screening method and therapeutic effect for Treponema hyodysenteriae -caused infection in CF-1 mice. J. Antibiot. 40(11), 1619–1626 (1987).

• 168 Nakagawa, Akira; Fujimoto, Tomoko; Ōmura, Satoshi; Walsh, James C.; Stotish, Ronald L.; George, Beverly. Hygromycin A, an antitreponemal substance. II. Therapeutic effect for swine dysentery. J. Antibiot. 40(11), 1627–1635 (1987).

• 169 Komiyama, Kanki; Hirokawa, Yumiko; Yamaguchi, Hiroko; Funayama, Shinji; Masuda, Kazuaki; Anraku, Yumi; Umezawa, Iwao; Ōmura, Satoshi. Antitumor activity of trienomycin A on murine tumors. J. Antibiot. 40(12), 1768–1772 (1987).

• 170 Masuma, Rokuro; Okuyama, Kazuko; Tanaka, Yoshitake; Hirose, Rimiko; Tomoda, Hiroshi; Iwai, Yuzuru; Ōmura, Satoshi. A new agar medium suitable for screening of anti-clostridium agents. J. Antibiot. 40(12), 1773–1775 (1987).

• 171 Tomoda, Hiroshi; Kumagai, Hidetoshi; Takahashi, Yoko; Tanaka, Yoshitake; Iwai, Yuzuru; Ōmura, Satoshi. F-244 (1233A), a specific inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A synthase: taxonomy of producing strain, fermentation, isolation and biological properties. J. Antibiot. 41(2), 247–249 (1988).

• 172 Otoguro, Kazuhiko; Nakagawa, Akira; Ōmura, Satoshi. Setamycin, a 16-membered macrolide antibiotic: identification and nematocidal activity. J. Antibiot. 41(2), 250–252 (1988).

• 173 Tanaka, Yoshitake; Kimura, Keiko; Komagata, Yasuko; Tsuzuki, Kazuo; Tomoda, Hiroshi; Ōmura, Satoshi. Radioimmunoassay for erythromycin derivatives. J. Antibiot. 41(2), 258–260 (1988).

• 174 Konda, Yaeko; Nakagawa, Akira; Harigaya, Yoshihiro; Onda, Masayuki; Masuma, Rokuro; Ōmura, Satoshi. Aurantinin B, a new antimicrobial antibiotic from bacterial origin. J. Antibiot. 41(2), 268–270 (1988).

• 175 Otoguro, Kazuhiko; Ōiwa, Ruiko; Iwai, Yuzuru; Tanaka, Haruo; Ōmura, Satoshi. Screening for new antitrichomonal substances of microbial origin and antitrichomonal activity of trichostatin A. J. Antibiot. 41(4), 461–468 (1988).

• 176 Otoguro, Kazuhiko; Liu, Zhong Xun; Fukuda, Keiko; Li, Yin; Iwai, Yuzuru; Tanaka, Haruo; Ōmura, Satoshi. Screening for new nematocidal substances of microbial origin by a new method using the pine wood nematode. J. Antibiot. 41(4), 573–575 (1988).

• 177 Shibata, Kiyoshi; Satsumabayashi, Sadayoshi; Sano, Hiroshi; Komiyama, Kanki; Nakagawa, Akira; Ōmura, Satoshi. Chemical modification of hitachimycin. Synthesis, antibacterial, cytocidal and in vivo antitumor activities of hitachimycin derivatives. J. Antibiot. 41(5), 614–623 (1988).

• 178 Ōmura, Satoshi; Nakagawa, Akira; Fukamachi, Nobuko; Miura, Satomi; Takahashi, Yoko; Komiyama, Kanki; Kobayashi, Bonro. OM-4842, a new platelet aggregation inhibitor from Streptomyces. J. Antibiot. 41(6), 812–813 (1988).

• 179 Uehara, Yoshimasa; Murakami, Yuko; Suzukake-Tsuchiya, Kayoko; Moriya, Yukari; Sano, Hiroshi; Shibata, Kiyoshi; Ōmura, Satoshi. Effect of herbimycin derivatives on src oncogene function in relation to antitumor activity. J. Antibiot. 41(6), 831–834 (1988).

• 180 Funayama, Shinji; Anraku, Yumi; Mita, Akira; Yang, Zhi Bo; Shibata, Kiyoshi; Komiyama, Kanki; Umezawa, Iwao; Ōmura, Satoshi. Structure-activity relationship of a novel antitumor ansamycin antibiotic trienomycin A and related compounds. J. Antibiot. 41(9), 1223–1230 (1988).

• 181 Ōmura, Satoshi; Tomoda, Hiroshi; Kimura, Keiko; Zhen, D. Z.; Kumagai, Hidetoshi; Igarashi, Kazuaki; Imamura, Nobutaka; Takahashi, Yoko; Tanaka, Yoshitake; Iwai, Yuzuru. Atpenins, new antifungal antibiotics produced by Penicillium sp. Production, isolation, physico-chemical and biological properties. J. Antibiot. 41(12), 1769–1773 (1988).

• 182 Ōmura, Satoshi; Tanaka, Yoshitake; Hisatome, Kazuyoshi; Miura, Satomi; Takahashi, Yoko; Nakagawa, Akira; Imai, Harumitsu. Phthoramycin, a new antibiotic active against a plant pathogen, Phytophthora sp. J. Antibiot. 41(12), 1910–1912 (1988).

• 183 Imamura, Nobutaka; Kuga, Hiroshi; Otoguro, Kazuhiko; Tanaka, Haruo; Ōmura, Satoshi. Structures of jietacines: unique α,β-unsaturated azoxy antibiotics. J. Antibiot. 42(1), 156–158 (1989).

• 184 Tanaka, Haruo; Kawakita, Kazuhito; Suzuki, Hidekazu; Spiri-Nakagawa, Priska; Ōmura, Satoshi. The mode of action of cervinomycin in Staphylococcus aureus. J. Antibiot. 42(3), 431–439 (1989).

• 185 Nomoto, Hisayo; Katsumata, Shigeo; Takahashi, Keiichi; Funayama, Shinji; Komiyama, Kanki; Umezawa, Iwao; Ōmura, Satoshi. Structural studies on minor components of trienomycin group antibiotics trienomycins D and E. J. Antibiot. 42(3), 479–481 (1989).

• 186 Shibata, Kiyoshi; Satsumabayashi, Sadayoshi; Sano, Hiroshi; Komiyama, Kanki; Yang, Zhibo; Nakagawa, Akira; Ōmura, Satoshi. Chemical modification of hitachimycin. II. Synthesis and antitumor activities of carbonate derivatives. J. Antibiot. 42(5), 718–726 (1989).

• 187 Tsuzuki, Kazuo; Yokozuka, Tadao; Murata, Masatsune; Tanaka, Haruo; Ōmura, Satoshi. Synthesis and biological activity of analogs of diazaquinomycin A, a new thymidylate synthase inhibitor. J. Antibiot. 42(5), 727–737 (1989).

• 188 Ōmura, Satoshi; Eda, Shigeru; Funayama, Shinji; Komiyama, Kanki; Takahashi, Yoko; Woodruff, H. Boyd. Studies on a novel antitumor antibiotic, phenazinomycin. taxonomy, fermentation, isolation, and physico-chemical and biological characteristics. J. Antibiot. 42(7), 1037–1042 (1989).

• 189 Shibata, Kiyoshi; Satsumabayashi, Sadayoshi; Sano, Hiroshi; Komiyama, Kanki; Yang, Zhi Bo; Nakagawa, Akira; Ōmura, Satoshi. Chemical modification of hitachimycin. III. Synthesis and antitumor activities of amino acyl derivatives. J. Antibiot. 42(7), 1114–1123 (1989).

• 190 Debono, Manuel; Willard, Kevin E.; Kirst, Herbert A.; Wind, Julie A.; Crouse, Gary D.; Tao, Eddie V.; Vicenzi, Jeffrey T.; Counter, Fred T.; Ott, John L.; Ose, Earle E.; Ōmura, Satoshi. Synthesis and antimicrobial evaluation of 20-deoxo-20-(3,5-dimethylpiperidin-l-yl)desmycosin (tilmicosin, EL-870) and related cyclic amino derivatives. J. Antibiot. 42(8), 1253–1267 (1989).

• 191 Imai, Harumitsu; Nakagawa, Akira; Ōmura, Satoshi. Biosynthesis of the antibiotic okilactomycin. J. Antibiot. 42(8), 1321–1323 (1989).

• 192 Nakagawa, Akira; Miura, Satomi; Imai, Harumitsu; Imamura, Nobutaka; Ōmura, Satoshi. Structure and biosynthesis of a new antifungal antibiotic, phthoramycin. J. Antibiot. 42(8), 1324–1327 (1989).

• 193 Komiyama, Kanki; Funayama, Shinji; Anraku, Yumi; Mita, Akira; Takahashi, Yoko; Ōmura, Satoshi; Shimasaki, Hiroyuki. Isolation of isoflavonoids possessing antioxidant activity from the fermentation broth of Streptomyces sp. J. Antibiot. 42(9), 1344–1349 (1989).

• 194 Funayama, Shinji; Anraku, Yumi; Mita, Akira; Komiyama, Kanki; Ōmura, Satoshi. Structural study of isoflavonoids possessing antioxidant activity isolated from the fermentation broth of Streptomyces sp. J. Antibiot. 42(9), 1350–1355 (1989).

• 195 Kirst, H. A.; Willard, K. E.; Debono, M.; Toth, J. E.; Truedell, B. A.; Leeds, J. P.; Ott, J. L.; Felty-Elty-Duckworth, A. M.; Counter, F. T.; Ose, E. E.; Crouse, G. D.; Tustin, J. M.; Ōmura, Satoshi. Structure-activity studies of 20-deoxo-20-amino derivatives of tylosin-related macrolides. J. Antibiot. 42 (11), 1673–1683 (1989).

• 196 Tanaka, Haruo; Kawakami, Takatoshi; Yang, Zhi Bo; Komiyama, Kanki; Ōmura, Satoshi. Potentiation of cytotoxicity and antitumor activity of adenosine analogs by the adenosine deaminase inhibitor adecypenol. J. Antibiot. 42(11), 1722–1724 (1989).

• 197 Funayama, Shinji; Ishibashi, Masami; Anraku, Yumi; Miyauchi, Mayumi; Mori, Hiroharu; Komiyama, Kanki; Ōmura, Satoshi. Novel cytocidal antibiotics, glucopiericidinols A₁ and A₂. Taxonomy, fermentation, isolation, structure elucidation and biological characteristics. J. Antibiot. 42(12), 1734–1740 (1989).

• 198 Masuma, Rokuro; Zhen, Dezhong; Tanaka, Yoshitake; Ōmura, Satoshi. Site of regulation of nanaomycin biosynthesis by inorganic phosphate. J. Antibiot. 43(1), 83–87 (1990).

• 199 Komiyama, Kanki; Funayama, Shinji; Anraku, Yumi; Ishibashi, Masami; Takahashi, Yoko; Ōmura, Satoshi. Novel antibiotics, furaquinocins A and B. Taxonomy, fermentation, isolation, and physico-chemical and biological characteristics. J. Antibiot. 43(3), 247–252 (1990).

• 200 Kakinuma, Shizuko; Ikeda, Haruo; Ōmura, Satoshi; Hopwood, David A. Biosynthesis of kalafungin in Streptomyces tanashiensis. J. Antibiot. 43(4), 391–396 (1990).

• 201 Kumagai, Hidetoshi; Tomoda, Hiroshi; Ōmura, Satoshi. Method of search for microbial inhibitors of mevalonate biosynthesis using animal cells. J. Antibiot. 43(4), 397–402 (1990).

• 202 Ōmura, Satoshi; Tanaka, Yoshitake; Kanaya, Isao; Shinose, Mayumi; Takahashi, Yoko. Phthoxazolin, a specific inhibitor of cellulose biosynthesis, produced by a strain of Streptomyces sp. J. Antibiot. 43(8), 1034–1036 (1990).

• 203 Oshino, Kazushi; Kumagai, Hidetoshi; Tomoda, Hiroshi; Ōmura, Satoshi. Mechanism of action of atpenin B on Raji cells. J. Antibiot. 43(9), 1064–1068 (1990).

• 204 Tomoda, Hiroshi; Ōmura, Satoshi. New strategy for discovery of enzyme inhibitors: screening with intact mammalian cells or intact microorganisms having special functions. J. Antibiot. 43(10), 1207–1222 (1990).

• 205 Mori, Hiroharu; Funayama, Shinji; Sudo, Yohei; Komiyama, Kanki; Ōmura, Satoshi. A new antibiotic, 13-hydroxyglucopiericidin A isolation, structure elucidation and biological characteristics. J. Antibiot. 43(10), 1329–1331 (1990).

• 206 Kumagai, Hidetoshi; Nishida, Hiroyuki; Imamura, Nobutaka; Tomoda, Hiroshi; Ōmura, Satoshi; Bordner, Jon. The structures of atpenins A4, A5 and B, new antifungal antibiotics produced by Penicillium sp. J. Antibiot. 43(12), 1553–1558 (1990).

• 207 Ōmura, Satoshi; Fujimoto, Tomoko; Otoguro, Kazuhiko; Matsuzaki, Keiichi; Moriguchi, Ryozo; Tanaka, Haruo; Sasaki, Yasuharu. Lactacystin, a novel microbial metabolite, induces neuritogenesis of neuroblastoma cells. J. Antibiot. 44(1), 113–116 (1991).

• 208 Ōmura, Satoshi; Matsuzaki, Keiichi; Fujimoto, Tomoko; Kosuge, Kazuhito; Furuya, Toshio; Fujita, Shigeo; Nakagawa, Akira. Structure of lactacystin, a new microbial metabolite which induces differentiation of neuroblastoma cells. J. Antibiot. 44(1), 117–118 (1991).

• 209 Tomoda, Hiroshi; Nishida, Hiroyuki; Masuma, Rokuro; Cao, Jing; Okuda, Shigenobu; Ōmura, Satoshi. Purpactins, new inhibitors of acyl-CoA: cholesterol acyltransferase produced by Penicillium purpurogenum. I. Production, isolation and physico-chemical and biological properties. J. Antibiot. 44(2), 136–143 (1991).

• 210 Nishida, Hiroyuki; Tomoda, Hiroshi; Cao, Jing; Okuda, Shigenobu; Ōmura, Satoshi. Purpactins, new inhibitors of acyl-CoA: cholesterol acyltransferase produced by Penicillium purpurogenum. II. Structure elucidation of purpactins A, B and C. J. Antibiot. 44(2), 144–151 (1991).

• 211 Nishida, Hiroyuki; Tomoda, Hiroshi; Cao, Jing; Araki, Sachiko; Okuda, Shigenobu; Ōmura, Satoshi. Purpactins, new inhibitors of acyl-CoA: cholesterol acyltransferase produced by Penicillium purpurogenum. III. Chemical modification of purpactin A. J. Antibiot. 44(2), 152–159 (1991).

• 212 Ishibashi, Masami; Funayama, Shinji; Anraku, Yumi; Komiyama, Kanki; Ōmura, Satoshi. Novel antibiotics, furaquinocins C, D, E, F, G and H. J. Antibiot. 44(4), 390–395 (1991).

• 213 Ōmura, Satoshi; Ikeda, Haruo; Tanaka, Haruo. Selective production of specific components of avermectins in Streptomyces avermitilis. J. Antibiot. 44(5), 560–563 (1991).

• 214 Tsuzuki, Kazuo; Yan, Fu Shan; Otoguro, Kazuhiko; Ōmura, Satoshi. Synthesis and nematocidal activities of jietacin A and its analogs. J. Antibiot. 44(7), 774–784 (1991).

• 215 Komiyama, Kanki; Funayama, Shinji; Anraku, Yumi; Ishibashi, Masami; Takahashi, Yoko; Kawakami, Takatoshi; Ōmura, Satoshi. A new antibiotic, okicenone. I. Taxonomy, fermentation, isolation and biological characteristics. J. Antibiot. 44(8), 814–818 (1991).

• 216 Funayama, Shinji; Ishibashi, Masami; Komiyama, Kanki; Ōmura, Satoshi. A new antibiotic, okicenone. II. Physico-chemical properties and structure elucidation. J. Antibiot. 44(8), 819–823 (1991).

• 217 Kakinuma, Shizuko; Takada, Yoshio; Ikeda, Haruo; Tanaka, Haruo; Ōmura, Satoshi; Hopwood, David A. Cloning of large DNA fragments, which hybridize with actinorhodin biosynthesis genes, from kalafungin and nanaomycin A methyl ester producers and identification of genes for kalafungin biosynthesis of the kalafungin producer. J. Antibiot. 44(9), 995–1005 (1991).

• 218 Kumagai, Hidetoshi; Tomoda, Hiroshi; Ōmura, Satoshi. Biosynthesis of antibiotic 1233A (F-244) and preparation of [¹⁴C]1233A. J. Antibiot. 45(4), 563–7 (1992).

• 219 Sunazuka, Toshiaki; Tsuzuki, Kazuo; Kumagai, Hidetoshi; Tomoda, Hiroshi; Tanaka, Haruo; Nagashima, Hajime; Hashizume, Hirokazu; Ōmura, Satoshi. Synthesis of 1233A analogs and their inhibitory activity against hydroxymethylglutaryl coenzyme A synthase. J. Antibiot. 45(7), 1139–1147 (1992).

• 220 Tomoda, Hiroshi; Huang, Xin Hui; Nishida, Hiroyuki; Masuma, Rokuro; Kim, Young Kook; Ōmura, Satoshi. Glisoprenins, new inhibitors of acyl-CoA. cholesterol acyltransferase produced by Gliocladium sp. FO-1513. I. Production, isolation, and physicochemical and biological properties. J. Antibiot. 45(8), 1202–1206 (1992).

• 221 Tomoda, Hiroshi; Nishida, Hiroyuki; Huang, Xin Hui; Masuma, Rokuro; Kim, Young Kook; Ōmura, Satoshi. New cyclodepsipeptides, enniatins D, E, and F produced by Fusarium sp. FO-1305. J. Antibiot. 45(8), 1207–1215 (1992).

• 222 Tomoda, Hiroshi; Huang, Xin Hui; Cao, Jin; Nishida, Hiroyuki; Nagao, Ryuichi; Okuda, Shigenobu; Tanaka, Haruo; Ōmura, Satoshi; Arai, Hiroyuki; Inoue, Keizo. Inhibition of acyl-CoA: cholesterol acyltransferase activity by cyclodepsipeptide antibiotics. J. Antibiot. 45(10), 1626–1632 (1992).

• 223 Nishida, Hiroyuki; Huang, Xin-Hui; Tomoda, Hiroshi; Ōmura, Satoshi. Glisoprenins, new inhibitors of acyl-CoA: cholesterol acetyltransferase produced by Gliocladium sp. FO-1513. II. Structure elucidation of glisoprenins A and B. J. Antibiot. 45(10), 1669–1676 (1992).

• 224 Funayama, Shinji; Nozoe, Shigeo; Tronquet, Claude; Anraku, Yumi; Komiyama, Kanki; Ōmura, Satoshi. Isolation and structure of a new polyether antibiotic, octacyclomycin. J. Antibiot. 45(10), 1686–1691 (1992).

• 225 Van der Pyl, Didier; Inokoshi, Junji; Shiomi, Kazuro; Yang, Hong; Takeshima, Hideo; Ōmura, Satoshi. Inhibition of farnesyl-protein transferase by gliotoxin and acetylgliotoxin. J. Antibiot. 45(11), 1802–1805 (1992).

• 226 Ōmura, Satoshi; Van Der Pyl, Didier; Inokoshi, Junji; Takahashi, Yoko; Takeshima, Hideo. Pepticinnamins, new farnesyl-protein transferase inhibitors produced by an actinomycete. I. Producing strain, fermentation, isolation, and biological activity. J. Antibiot. 46(2), 222–228 (1993).

• 227 Shiomi, Kazuro; Yang, Hong; Inokoshi, Junji; Van Der Pyl, Didier; Nakagawa, Akira; Takeshima, Hideo; Ōmura, Satoshi. Pepticinnamins, new farnesyl-protein transferase inhibitors produced by an actinomycete. II. Structural elucidation of pepticinnamin E. J. Antibiot. 46(2), 229–234 (1993).

• 228 Tabata, Noriko; Suzumura, Yasuko; Tomoda, Hiroshi; Masuma, Rokuro; Haneda, Katsuji; Kishi, Masanori; Iwai, Yuzuru; Ōmura, Satoshi. Xanthoquinodins, new anticoccidial agents produced by Humicola sp.: production, isolation, and physico-chemical and biological properties. J. Antibiot. 46(5), 749–755 (1993).

• 229 Tabata, Noriko; Tomoda, Hiroshi; Takahashi, Yoko; Haneda, Katsuji; Iwai, Yuzuru; Woodruff, H. Boyd; Ōmura, Satoshi. Diolmycins, new anticoccidial agents produced by Streptomyces sp. I. Production, isolation, and physico-chemical and biological properties. J. Antibiot. 46(5), 756–761 (1993).

• 230 Tabata, Noriko; Sunazuka, Toshiaki; Tomoda, Hiroshi; Nagamitsu, Tohru; Iwai, Yuzuru; Ōmura, Satoshi. Diolmycins, new anticoccidial agents produced by Streptomyces sp. II. Structure elucidation of diolmycins A1, A2, B1 and B2, and synthesis of diolmycin A1. J. Antibiot. 46(5), 762–769 (1993).

• 231 Tomoda, Hiroshi; Kumagai, Hidetoshi; Tanaka, Haruo; Ōmura, Satoshi. Specific binding of β-lactone 1233A to 3-hydroxy-3-methylglutaryl-coenzyme A synthase. J. Antibiot. 46(5), 872–874 (1993).

• 232 Ōmura, Satoshi; Tomoda, Hiroshi; Kim, Young Kook; Nishida, Hiroyuki. Pyripyropenes, highly potent inhibitors of acyl-CoA: cholesterol acyltransferase produced by Aspergillus fumigatus. J. Antibiot. 46(7), 1168–1169 (1993).

• 233 Sunazuka, Toshiaki; Tabata, Noriko; Nagamitsu, Tohru; Tomoda, Hiroshi; Ōmura, Satoshi. Synthesis of diolmycin analogs and their anticoccidial activities. J. Antibiot. 46(7), 1178–1180 (1993).

• 234 Tanaka, Yoshitake; Kanaya, Isao; Takahashi, Yoko; Shinose, Mayumi; Tanaka, Haruo; Ōmura, Satoshi. Phthoxazolin A, a specific inhibitor of cellulose biosynthesis from microbial origin. I. Discovery, taxonomy of producing microorganism, fermentation, and biological activity. J. Antibiot. 46(8), 1208–1213 (1993).

• 235 Tanaka, Yoshitake; Kanaya, Isao; Shiomi, Kazuro; Tanaka, Haruo; Ōmura, Satoshi. Phthoxazolin A, a specific inhibitor of cellulose biosynthesis from microbial origin. II. Isolation, physico-chemical properties, and structural elucidation. J. Antibiot. 46(8), 1214–1218 (1993).

• 236 Komiyama, Kanki; Takamatsu, Satoshi; Takahashi, Yoko; Shinose, Mayumi; Hayashi, Masahiko; Tanaka, Haruo; Iwai, Yuzuru; Ōmura, Satoshi; Imokawa, Genji. New inhibitors of melanogenesis, OH-3984 K1 and K2. I. Taxonomy, fermentation, isolation and biological characteristics. J. Antibiot. 46(10), 1520–1525 (1993).

• 237 Takamatsu, Satoshi; Rho, Mun Chual; Hayashi, Masahiko; Komiyama, Kanki; Tanaka, Haruo; Ōmura, Satoshi; Imokawa, Genji. New inhibitors of melanogenesis, OH-3984 K1 and K2. II. Physico-chemical properties and structural elucidation. J. Antibiot. 46(10), 1526–1529 (1993).

• 238 Komiyama, Kanki; Otoguro, Kazuhiko; Segawa, Toshiaki; Shiomi, Kazuro; Yang, Hong; Takahashi, Yoko; Hayashi, Masahiko; Otani, Toshio; Ōmura, Satoshi. A new antibiotic, cypemycin: taxonomy, fermentation, isolation and biological characteristics. J. Antibiot. 46(11), 1666–1671 (1993).

• 239 Tabata, Noriko; Tomoda, Hiroshi; Masuma, Rokuro; Haneda, Katsuji; Iwai, Yuzuru; Ōmura, Satoshi. Hynapenes A, B and C, new anticoccidial agents produced by Penicillium sp. I. Production, isolation and physico-chemical and biological properties. J. Antibiot. 46(12), 1849–1853 (1993).

• 240 Tabata, Noriko; Tomoda, Hiroshi; Iwai, Yuzuru; Ōmura, Satoshi. Hynapenes A, B and C, new anticoccidial agents produced by Penicillium sp. II. Structure elucidation. J. Antibiot. 46(12), 1854–1858 (1993).

• 241 Ōmura, Satoshi; Tanaka, Haruo; Matsuzaki, Keiichi; Ikeda, Hodaka; Masuma, Rokuro. Isochromophilones I and II, novel inhibitors against gp120-CD4 binding from Penicillium sp. J. Antibiot. 46(12), 1908–1911 (1993).

• 242 Masuma, Rokuro; Tabata, Noriko; Tomoda, Hiroshi; Haneda, Katsuji; Iwai, Yuzuru; Ōmura, Satoshi. Arohynapenes A and B, new anticoccidial agents produced by Penicillium sp. Taxonomy, fermentation, and structure elucidation. J. Antibiot. 47(1), 46–53 (1994).

• 243 Tomoda, Hiroshi; Kim, Young Kook; Nishida, Hiroyuki; Masuma, Rokuro; Ōmura, Satoshi. Pyripyropenes, novel inhibitors of acyl-CoA. cholesterol acyltransferase produced by Aspergillus fumigatus. I. Production, isolation, and biological properties. J. Antibiot. 47(2), 148–153 (1994).

• 244 Kim, Young Kook; Tomoda, Hiroshi; Nishida, Hiroyuki; Sunazuka, Toshiaki; Obata, Rika; Ōmura, Satoshi. Pyripyropenes, novel inhibitors of acyl-CoA: cholesterol acyltransferase produced by Aspergillus fumigatus. II. Structure elucidation of pyripyropenes A, B, C and D. J. Antibiot. 47(2), 154–162 (1994).

• 245 Haneda, Katuji; Shinose, Mayumi; Seino, Akio; Tabata, Noriko; Tomoda, Hiroshi; Iwai, Yuzuri; Ōmura, Satoshi. Cytosaminomycins, new anticoccidial agents produced by Streptomyces sp. KO-8119. I. Taxonomy, production, isolation and physico-chemical and biological properties. J. Antibiot. 47(7), 774–781 (1994).

• 246 Shiomi, Kazuro; Haneda, Katsuji; Tomoda, Hiroshi; Iwai, Yuzuru; Ōmura, Satoshi. Cytosaminomycins, new anticoccidial agents produced by Streptomyces sp. KO-8119. II. Structure elucidation of cytosaminomycins A, B, C and D. J. Antibiot. 47(7), 782–786 (1994).

• 247 Yoshida, Hiroshi; Arai, Noriko; Sugoh, Masako; Shiomi, Kazuro; Shinose, Mayumi; Tanaka, Yoshitake; Ōmura, Satoshi. 4-Chlorothreonine, a herbicidal antimetabolite produced by Streptomyces sp. OH-5093. J. Antibiot. 47(10), 1165–1166 (1994).

• 248 Matsuzaki, Keiichi; Ikeda, Hodaka; Ogino, Tomoaki; Matsumoto, Atsuko; Woodruff, H. Boyd; Tanaka, Haruo; Ōmura, Satoshi. Chloropeptins I and II, novel inhibitors against gp120-CD4 binding from Streptomyces sp. J. Antibiot. 47(10), 1173–1174 (1994).

• 249 Huang, Xin-Hui; Tomoda, Hiroshi; Nishida, Hiroyuki; Masuma, Rokuro; Ōmura, Satoshi. Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. I. Production, isolation and biological properties. J. Antibiot. 48(1), 1–4 (1995).

• 250 Huang, Xin-Hui; Nishida, Hiroyuki; Tomoda, Hiroshi; Tabata, Noriko; Shiomi, Kazuro; Yang, Da-Jun; Takayanagi, Hiroaki; Ōmura, Satoshi. Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. II. Structure elucidation of terpendoles A, B, C and D. J. Antibiot. 48(1), 5–11 (1995).

• 251 Tabata, Noriko; Tomoda, Hiroshi; Masuma, Rokuro; Iwai, Yuzuru; Ōmura, Satoshi. Fudecalone, a new anticoccidial agent produced by Penicillium sp. FO-2030. J. Antibiot. 48(1), 53–58 (1995).

• 252 Pang, Chang-Hong; Matsuzaki, Keiichi; Ikeda, Haruo; Tanaka, Haruo; Ōmura, Satoshi. Production of 6,8a-seco-6,8a-deoxy derivatives of avermectins by a mutant strain of Streptomyces avermitilis. J. Antibiot. 48(1), 59–66 (1995).

• 253 Tabata, Noriko; Tomoda, Hiroshi; Iwai, Yuzuru; Ōmura, Satoshi. Arohynapene D, a new anticoccidial agent produced by Penicillium sp. FO-2295. J. Antibiot. 48(1), 83–84 (1995).

• 254 Pang, Chang-Hong; Matsuzaki, Keiichi; Ikeda, Haruo; Tanaka, Haruo; Ōmura, Satoshi. Production of a new methylated 6,8a-seco-6,8a-deoxy derivative of the avermectins by a transformant strain of Streptomyces avermitilis. J. Antibiot. 48(1), 92–94 (1995).

• 255 Ikeda, Haruo; Takada, Yoshio; Pang, Chang-Hong; Matsuzaki, Keiichi; Tanaka, Haruo; Ōmura, Satoshi. Direct production of 5-oxo derivatives of avermectins by a recombinant strain of Streptomyces avermitilis. J. Antibiot. 48(1), 95–97 (1995).

• 256 Yamada, Haruki; Shiomi, Kazuro; Xu, Qi; Nagai, Takayuki; Shibata, Maki; Oya, Izumi; Takahashi, Yoko; Ōmura, Satoshi. New glycosidases inhibitors, panosialins D and wD produced by Streptomyces sp. OH-5186. J. Antibiot. 48(3), 205–209 (1995).

• 257 Katagiri, Masako; Hayashi, Masahiko; Matsuzaki, Keiichi; Tanaka, Haruo; Ōmura, Satoshi. The neuritogenesis inducer lactacystin arrests cell cycle at both G0/G1 and G2 phases in Neuro 2a cells. J. Antibiot. 48(4), 344–346 (1995).

• 258 Kakinuma, Shizuko; Ikeda, Harudo; Takada, Yoshio; Tanaka, Haruo; Hopwood, David A.; Ōmura, Satoshi. Production of the new antibiotic tetrahydrokalafungin by transformants of the kalafungin producer Streptomyce stanashiensis. J. Antibiot. 48(6), 484–487 (1995).

• 259 Tomoda, Hiroshi; Tabata, Noriko; Yang, Da-Jun; Takayanagi, Hiroaki; Nishida, Hiroyuki; Ōmura, Satoshi. Pyripyropenes, novel ACAT inhibitors produced by Aspergillus fumigatus. III. Structure elucidation of pyripyropenes E to L. J. Antibiot. 48(6), 495–503 (1995).

• 260 Ikeda, Haruo; Pang, Chang-Hong; Endo, Hirofumi; Ohta, Toshio; Tanaka, Haruo; Ōmura, Satoshi. Construction of a single component producer from the wild-type avermectin producer Streptomyces avermitilis. J. Antibiot. 48(6), 532–534 (1995).

• 261 Ōmura, Satoshi; Sasaki, Yasuharu; Iwai, Yuzuru; Takeshima, Hideo. Staurosporine, a potentially important gift from a microorganism. J. Antibiot. 48(7), 535–548 (1995).

• 262 Ikeda, Haruo; Ōmura, Satoshi. Control of avermectin biosynthesis in Streptomyces avermitilis for the selective production of a useful component. J. Antibiot. 48(7), 549–562 (1995).

• 263 Arai, Noriko; Shiomi, Kazuro; Tomoda, Hiroshi; Tabata, Noriko; Yang, Da Jun; Masuma, Rokuro; Kawakubo, Tomoya; Ōmura, Satoshi. Isochromophilones III-VI, inhibitors of acyl-CoA: cholesterol acyltransferase produced by Penicillium multicolor FO-3216. J. Antibiot. 48(7), 696–702 (1995).

• 264 Matsuzaki, Keiichi; Ikeda, Hodaka; Masuma, Rokuro; Tanaka, Haruo; Ōmura, Satoshi. Isochromophilones I and II, novel inhibitors against gp120-CD4 binding produced by Penicillium multicolor FO-2338. I. Screening, taxonomy, fermentation, isolation and biological activity. J. Antibiot. 48(7), 703–707 (1995).

• 265 Matsuzaki, Keiichi; Tanaka, Haruo; Ōmura, Satoshi. Isochromophilones I and II, novel inhibitors against gp120-CD4 binding produced by Penicillium multicolor FO-2338. II. Structure elucidation. J. Antibiot. 48(7), 708–713 (1995).

• 266 Shiomi, Kazuro; Arai, Noriko; Shinose, Mayumi; Takahashi, Yoko; Yoshida, Hiroshi; Iwabuchi, Jun; Tanaka, Yoshitake; Ōmura, Satoshi. New antibiotics phthoxazolins B, C and D produced by Streptomyces sp. KO-7888. J. Antibiot. 48(7), 714–719 (1995).

• 267 Tanaka, Yoshitake; Sugoh, Masako; Ji, Wei; Iwabuchi, Jun; Yoshida, Hiroshi; Ōmura, Satoshi. Screening method for cellulose biosynthesis inhibitors with herbicidal activity. J. Antibiot. 48(7), 720–724 (1995).

• 268 Ōmura, Satoshi; Kuno, Fumiyoshi; Otoguro, Kazuhiko; Sunazuka, Toshiaki; Shiomi, Kazuro; Masuma, Rokuro; Iwai, Yuzuru. Arisugacin, a novel land selective inhibitor of acetylcholinesterase from Penicillium sp. FO-4259. J. Antibiot. 48(7), 745–746 (1995).

• 269 Nagamitsu, Tohru; Sunazuka, Toshiaki; Stump, Heike; Obata, Rika; Arima, Shiho; Matsuzaki, Keiichi; Tanak, Haruo; Ōmura, Satoshi. Structure-activity relationships of lactacystin, the first non-protein neurotrophic factor. J. Antibiot. 48(7), 747–748 (1995).

• 270 Obata, Rika; Sunazuka, Toshiaki; Zhuorong, Li; Tomoda, Hiroshi; Ōmura, Satoshi. Structure-activity relationships of pyripyropenes fungal acyl-CoA: cholesterol acyltransferase inhibitors. J. Antibiot. 48(7), 749–750 (1995).

• 271 Tomoda, Hiroshi; Tabata, Noriko; Yang, Da-Jun; Takayanagi, Hiroaki; Ōmura, Satoshi. Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. III. Production, isolation and structure elucidation of new components. J. Antibiot. 48(8), 793–804 (1995).

• 272 Tomoda, Hiroshi; Ito, Minako; Tabata, Noriko; Masuma, Rokuro; Yamaguchi, Yuichi; Ōmura, Satoshi. Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. I. Production, isolation and biological properties. J. Antibiot. 48(9), 937–941 (1995).

• 273 Tomoda, Hiroshi; Tabata, Noriko; Ito, Minako; Ōmura, Satoshi. Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO–2942. II. Structure elucidation of amidepsines A, B and C. J. Antibiot. 48(9), 942–947 (1995).

• 274 Takahashi, Senji; Uchida, Kenichi; Nakagawa, Akira; Miyake, Yoko; Kainosho, Masatsune; Matsuzaki, Keiichi; Ōmura, Satoshi. Biosynthesis of lactacystin. J. Antibiot. 48(9), 1015–1020 (1995).

• 275 Komiyama, Kanki; Takamatsu, Satoshi; Kim, Yong-Pil; Matsumoto, Atsuko; Takahashi, Yoko; Hayashi, Masahiko; Woodruff, H. Boyd; Ōmura, Satoshi. Louisianins A, B, C and D: non-steroidal growth inhibitors of testosterone-responsive SC 115 cells. I. Taxonomy, fermentation, isolation and biological characteristics. J. Antibiot. 48(10), 1086–1089 (1995).

• 276 Takamatsu, Satoshi; Kim, Yong-Pil; Hayashi, Masahiko; Furuhata, Kimio; Takayanagi, Hiroaki; Komiyama, Kanki; Woodruff, H. Boyd; Ōmura, Satoshi. Louisianines A, B, C and D: non-steroidal growth inhibitors of testosterone-responsive SC 115 cells. II. Physico-chemical properties and structural elucidation. J. Antibiot. 48(10), 1090–1094 (1995).

• 277 Shiomi, Kazuro; Yang, Hong; Xu, Qi; Arai, Noriko; Namiki, Mikie; Hayashi, Masahiko; Inokoshi, Junji; Takeshima, Hideo; Masuma, Rokuro; Komiyama, Kanki; Ōmura, Satoshi. Phenopyrrozin, a new radical scavenger produced by Penidllium sp. FO-2047. J. Antibiot. 48(12), 1413–1418 (1995).

• 278 Hayashi, Masahiko; Kim, Yong-Pil; Hiraoka, Hidemi; Natori, Masahiko; Takamatsu, Satoshi; Kawakubo, Tomoya; Masuma, Rokuro; Komiyama, Kanki; Ōmura, Satoshi. Macrosphelide, a novel inhibitor of cell-cell adhesion molecule. I. Taxonomy, fermentation, isolation and biological activities. J. Antibiot. 48(12), 1435–1439 (1995).

• 279 Tanaka, Yoshitake; Sugoh, Masako; Yoshida, Hiroshi; Arai, Noriko; Shiomi, Kazuro; Matsumoto, Atsuko; Takahashi, Yoko; Ōmura, Satoshi. Hydranthomycin, a new agroactive antibiotic produced by Streptomyces sp. K93-5305. J. Antibiot. 48(12), 1525–1526 (1995).

• 280 Enomoto, Yumi; Shiomi, Kazuro; Hayashi, Masahiko; Masuma, Rokuro; Kawakubo, Tomoya; Tomosawa, Keiichi; Iwai, Yuzuru; Ōmura, Satoshi. Herquline B, a new platelet aggregation inhibitor produced by Penicillium herquei Fg-372. J. Antibiot. 49(1), 50–53 (1996).

• 281 Takamatsu, Satoshi; Kim, Yong-Pil; Hayashi, Masahiko; Hiraoka, Hidemi; Natori, Masahiko; Ko, Iyama, Kanki; Ōmura, Satoshi. Macrosphelide, a novel inhibitor of cell-cell adhesion molecule. II. Physicochemical properties and structural elucidation. J. Antibiot. 49(1), 95–98 (1996).

• 282 Yang, Da-Jun; Tomoda, Hiroshi; Tabata, Noriko; Masuma, Rokuro; Ōmura, Satoshi. New isochromophilones VII and VIII produced by Penicillium sp. FO-4164. J. Antibiot. 49(3), 223–229 (1996).

• 283 Tabata, Noriko; Tomoda, Hiroshi; Iwai, Yuzuru; Ōmura, Satoshi. Xanthoquinodin B3, a new anticoccidial agent produced by Humicola sp. FO-888. J. Antibiot. 49(3), 267–271 (1996).

• 284 Tomoda, Hiroshi; Tabata, Noriko; Yang, Da-Jun; Namatame, Ichiji; Tanaka, Haruo; Ōmura, Satoshi. Pyripyropenes, novel ACAT inhibitors produced by Aspergillus fumigatus IV. Structure elucidation of pyripyropenes M to R. J. Antibiot. 49(3), 292–298 (1996).

• 285 Ōmura, Satoshi; Inokoshi, Junji; Uchida, Ryuji; Shiomi, Kazuro; Masuma, Rokuro; Kawakubo, Tomoya; Tanaka, Haruo; Iwai, Yuzuru; Kosemura, Seiji; Yamamura, Shosuke. Andrastins A-C, new protein farnesyltransferase inhibitors produced by Penicillium sp. FO-3929. I. Producing strain, fermentation, isolation, and biological activities. J. Antibiot. 49(5), 414–417 (1996).

• 286 Uchida, Ryuji; Shiomi, Kazuro; Inokoshi, Junji; Sunazuka, Toshiaki; Tanaka, Haruo; Iwai, Yuzuru; Takayanagi, Hiroaki; Ōmura, Satoshi. Andrastins A-C, new protein farnesyltransferase inhibitors produced by Penidllium sp. FO-3929. II. Structure elucidation and biosynthesis. J. Antibiot. 49(5), 418–424 (1996).

• 287 Takamatsu, Satoshi; Kim, Yong-Pil; Hyashi, Masahiko; Komiyama, Kanki; Imokawa, Genji; Ōmura, Satoshi. A new inhibitor of melanogenesis, albocycline K3, produced by Streptomyces sp. OH-3984. J. Antibiot. 49(5), 485–486 (1996).

• 288 Hayashi, Masahiko; Kim, Yong-Pil; Takamatsu, Satoshi; Preeprame, Srisomporn; Komiya, Takamaro; Masuma, Rokuro; Tanaka, Haruo; Komiyama, Kanki; Ōmura, Satoshi. Chlovalicin, a new cytocidal antibiotic produced by Sporothrix sp. FO-4649. I. Taxonomy, fermentation, isolation and biological activities. J. Antibiot. 49(7), 631–634 (1996).

• 289 Takamatsu, Satoshi; Kim, Yong-Pil; Komiya, Takamaro; Sunazuka, Toshiaki; Hayashi, Masahiko; Tanaka, Haruo; Komiyama, Kanki; Ōmura, Satoshi. Chlovalicin, a new cytocidal antibiotic produced by Sporothrix sp. FO-4649. II. Physicochemical properties and structural elucidation. J. Antibiot. 49(7), 635–638 (1996).

• 290 Sun, Xue-Long; Takayanagi, Hiroaki; Matsuzaki, Keiichi; Tanaka, Haruo; Furuhata, Kimio; Ōmura, Satoshi. Synthesis and inhibitory activities of isochromophilone analogs against gp120-CD4 binding. J. Antibiot. 49(7), 689–692 (1996).

• 291 Nakagawa, Akira; Ōmura, Satoshi. Biosynthesis of bioactive microbial metabolites and its application to the structural studies and production of hybrid compounds. J. Antibiot. 49(8), 717–741 (1996).

• 292 Kuno, Fumiyoshi; Otoguro, Kazuhiko; Shiomi, Kazuro; Iwai, Yuzuru; Ōmura, Satoshi. Arisugacins A and B, novel and selective acetylcholinesterase inhibitors from Penicillium sp. FO-4259. I. Screening, taxonomy, fermentation, isolation and biological activity. J. Antibiot. 49(8), 742–747 (1996).

• 293 Kuno, Fumiyoshi; Shiomi, Kazuro; Otoguro, Kazuhiko; Sunazuka, Toshiaki; Ōmura, Satoshi. Arisugacins A and B, novel and selective acetylcholinesterase inhibitors from Penicillium sp. FO-4259. II. Structure elucidation. J. Antibiot. 49(8), 748–751 (1996).

• 294 Funabashi, Yasunori; Maeshiba, Yoshihiro; Inatomi, Nobuhiro; Tanayama, shigeharu; Harada, Setsuo; Itoh, Zen; Ōmura, Satoshi. Bioactive metabolites of EM574 and EM523, erythromycin derivatives having strong gastrointestinal motor stimulating activity. J. Antibiot. 49(8), 794–801 (1996).

• 295 Funabashi, Yasujoro; Hakoda, Seiji; Inatomi, Nobuhiro; Koyama, Katsuo; Tanida, Seiichi; Harada, Setsuo; Itoh, Zen; Ōmura, Satoshi. Microbial conversion of EM574 and EM523, gastrointestinal motor stimulating agents. J. Antibiot. 49(8), 802–810 (1996).

• 296 Uchida, Ryuji; Shiomi, Kazuro; Sunazuka, Toshiaki; Inokoshi, Junji; Nishizawa, Ai; Hirose, Tomoyasu; Tanaka, Haruo; Iwai, Yuzuru; Ōmura, Satoshi. Kurasoins A and B, new protein farnesyltransferase inhibitors produced by Paecilomyces sp. FO-3684. II. Structure elucidation and total synthesis. J. Antibiot. 49(9), 886–889 (1996).

• 297 Tomoda, Hiroshi; Yamaguchi, Yuichi; Tabata, Noriko; Kobayashi, Tatsuya; Masuma, Rokuro; Tanaka, Haruo; Ōmura, Satoshi. Amidepsine E, an inhibitor of diacylglycerol acyltransferase produced by Humicola sp. FO-5969. J. Antibiot. 49(9), 929–931 (1996).

• 298 Uchida, Ryuji; Shiomi, Kazuro; Inokoshi, Junji; Masuma, Pokuro; Kawakubo, Tomoya; Tanaka, Haruo; Iwai, Yuzuru; Ōmura, Satoshi. Kurasoins A and B, new protein farnesyltransferase inhibitors produced by Paecilomyces sp. FO-3684. I. Producing strain, fermentation, isolation, and biological activities. J. Antibiot. 49(9), 932–934 (1996).

• 299 Sztaricskai, Ferenc; Dinya, Zoltan; Puskas, Maria M.; Batta, Gyula; Masuma, Rokuro; Ōmura, Satoshi. Semisynthetic modification of antibiotic lincomycin. J. Antibiot. 49(9), 941–943 (1996).

• 300 Tanaka, Yoshitake; Matsuzaki, Keiichi; Zhong, Chong-Lin; Yoshida, Hiroshi; Kawakubo, Tomoya; Masuma, Rokuro; Tanaka, Haruo; Ōmura, Satoshi. Dechlorogeodin and its new dihydro derivatives, fungal metabolites with herbicidal activity. J. Antibiot. 49(10), 1056–1059 (1996).

• 301 Yamada, Rintaro; Seto, Minoru; Sasaki, Yasuharu; Sunazuka, Toshiaki; Harigaya, Yoshihiro; Iwai, Yuzuru; Ōmura, Satoshi. Synthesis and anti-platelet aggregation activity of water-soluble staurosporine derivatives. J. Antibiot. 49(10), 1070–1072 (1996).

• 302 Hayashi, Masahiko; Kim, Yong-Pil; Takamatsu, Satoshi; Enomoto, Akiko; Shinose, Mayumi; Takahashi, Yoko; Tanaka, Haruo; Komiyama, Kanki; Ōmura, Satoshi. Madindoline, a novel inhibitor of IL–6 activity from Streptomyces sp. K93-0711. I. Taxonomy, fermentation, isolation and biological activities. J. Antibiot. 49(11), 1091–1095 (1996).

• 303 Obata, Rika; Sunazuka, Toshiaki; Li, Zhuorong; Tian, Zhiming; Harigaya, Yoshihiro; Tabata, Noriko; Tomoda, Hiroshi; Ōmura, Satoshi. Chemical modification and structure-activity relationships of pyripyropenes. 1. Modification at the four hydroxyl groups. J. Antibiot. 49(11), 1133–1148 (1996).

• 304 Obata, Rika; Sunazuka, Toshiaki; Kato, Yumiko; Tomoda, Hiroshi; Harigaya, Yoshihiro; Ōmura, Satoshi. Chemical modification and structure-activity relationships of pyripyropenes. 2. 1,11-Cyclic analogs. J. Antibiot. 49(11), 1149–1156 (1996).

• 305 Uchida, Ryuji; Shiomi, Kazuro; Inokoshi, Junji; Tanaka, Haruo; Iwai, Yuzuru; Ōmura, Satoshi. Andrastin D, novel protein farnesyltransferase inhibitor produced by Penicillium sp. FO-3929. J. Antibiot. 49 (12), 1278–1280 (1996).

• 306 Tanaka, Haruo; Matsuzaki, Keiichi; Nakashima, Hideki; Ogino, Tomoaki; Matsumoto, Atsuko; Ikeda, Hodaka; Woodruff, H. Boyd; Ōmura, Satoshi. Chloropeptins, New anti-HIV antibiotics inhibiting gp120-CD4 binding from Streptomyces sp. I. Taxonomy, fermentation, isolation, and physico-chemical properties, and biological activities. J. Antibiot. 50(1), 58–65 (1997).

• 307 Matsuzaki, Keiichi; Ogino, Tomoaki; Sunazuka, Toshiaki; Tanaka, Haruo; Ōmura, Satoshi. Chloropeptins, new anti-HIV antibiotics inhibiting gp120-CD4 binding from Streptomyces sp. II. Structure elucidation of chloropeptin I. J. Antibiot. 50(1), 66–69 (1997).

• 308 Kim, Yong-Pil; Takamatsu, Satoshi; Hayashi, Masahiko; Komiyama, Kanki; Ōmura, Satoshi. Pyridindolols K1 and K2, new alkaloids from Streptomyces sp. K93-0711. J. Antibiot. 50(3), 189–193 (1997).

• 309 Tanaka, Yoshitake; Yoshida, Hiroshi; Enomoto, Yumi; Shiomi, Kazuro; Shinose, Mayumi; Takahashi, Yoko; Liu, Jing-Rong; Ōmura, Satoshi. Malolactomycins C and D, new 40-membered macrolides active against Botrytis. J. Antibiot. 50(3), 194–200 (1997).

• 310 Obata, Rika; Sunazuka, Toshiaki; Tian, Zhiming; Tomoda, Hiroshi; Harigaya, Yoshihiro; Ōmura, Satoshi. Chemical modification and structure-activity relationships of pyripyropenes. 3. Synthetic conversion of pyridine-pyrone moiety. J. Antibiot. 50(3), 229–236 (1997).

• 311 Sunazuka, Toshiaki; Zhi-Ming, Tian; Harigaya, Yoshihiro; Takamatsu, Satoshi; Hayashi, Masahiko; Komiyama, Kanki; Ōmura, Satoshi. Efficient chemical conversion of louisianine A to C and D, the inhibitor of angiogenesis. J. Antibiot. 50(3), 274–275 (1997).

• 312 Sunazuka, Toshiaki; Hirose, Tomoyasu; Zhi-Ming, Tian; Uchida, Ryuji; Shiomi, Kazuro; Harigaya, Yoshihiro; Ōmura, Satoshi. Syntheses and absolute structures of novel protein farnesyltransferase inhibitors, kurasoins A and B. J. Antibiot. 50(5), 453–455 (1997).

• 313 Arai, Noriko; Shiomi, Kazuro; Takamatsu, Satoshi; Komiyama, Kanki; Shinose, Mayumi; Takahashi, Yoko; Tanaka, Yoshitake; Iwai, Yuzuru; Liu, Jing-Rong; Ōmura, Satoshi. Amphistin, a new melanogenesis inhibitor, produced by an actinomycete. J. Antibiot. 50(10), 808–814 (1997).

• 314 Sztaricskai, Ferenc; Dinya, Zoltan; Batta, Gyula; Mocsari, Aniko; Hollosi, Miklos; Majer, Zsuzsa; Masuma, Rokuro; Ōmura, Satoshi. Chemical synthesis and structural study of lincomycin sulfoxides and a sulfone. J. Antibiot. 50(10), 866–873 (1997).

• 315 Takamatsu, Satoshi; Hiraoka, Hidemi; Kim, Yong-Pil; Hayashi, Masahiko; Natori, Masahiko; Komiyama, Kanki; Ōmura, Satoshi. Macrosphelides C and D, novel inhibitors of cell adhesion. J. Antibiot. 50(10), 878–880 (1997).

• 316 Fang, Fang; Ui, Hideaki; Shiomi, Kazuro; Masuma, Rokuro; Yamaguchi, Yuuichi; Zhang, Cheng Gang; Zhang, Xian Wu; Tanaka, Yoshitake; Ōmura, Satoshi. Two new components of the aspochalasins produced by Aspergillus sp. J. Antibiot. 50(11), 919–925 (1997).

• 317 Takamatsu, Satoshi; Kim, Yong-Pil; Enomoto, Akiko; Hayashi, Masahiko; Tanaka, Haruo; Komiyama, Kanki; Ōmura, Satoshi. Madindolines, novel inhibitors of IL-6 activity from Streptomyces sp. K93-0711. II. Physico-chemical properties and structural elucidation. J. Antibiot. 50(12), 1069–1072 (1997).

• 318 Rho, Mun-Chual; Toyoshima, Mitsuhide; Hayashi, Masahiko; Uchida, Ryuji; Shiomi, Kazuro; Komiyama, Kanki; Ōmura, Satoshi. Enhancement of drug accumulation by andrastin A produced by Penicillium sp. FO-3929 in vincristine-resistant KB cells. J. Antibiot. 51(1), 68–72 (1998).

• 319 Tanaka, Yoshitake; Shiomi, Kazuro; Kamei, Kiseko; Sugoh-Hagino, Masako; Enomoto, Yumi; Fang, Fang; Yamaguchi, Yuuichi; Masuma, Rokuro; Zhang, Cheng Gang; Zhang, Xian Wu; Ōmura, Satoshi. Antimalarial activity of radicicol, heptelidic acid and other fungal metabolites. J. Antibiot. 51(2), 153–160 (1998).

• 320 Tanaka, Yoshitake; Fang, Fang; Zhang, Cheng Gang; Zhang, Xian Wu; Ōmura, Satoshi. Heme-dependent radical generation from antimalarial fungal metabolites, radicicol and heptelidic acid. J. Antibiot. 51(4), 451–453 (1998).

• 321 Tomoda, Hiroshi; Tabata, Noriko; Masuma, Rokuro; Si, Shu-Yi; Ōmura, Satoshi. Erabulenols, inhibitors of cholesteryl ester transfer protein produced by Penicillium sp. FO-5637. I. Production, isolation and biological properties. J. Antibiot. 51(7), 618–623 (1998).

• 322 Tabata, Noriko; Tomoda, Hiroshi; Ōmura, Satoshi. Erabulenols, inhibitors of cholesteryl ester transfer protein produced by Penicillium sp. FO-5637, II. Structure elucidation of erabulenols A and B. J. Antibiot. 51(7), 624–628 (1998).

• 323 Matsuzaki, Keiichi; Tahara, Harumi; Inokoshi, Junji; Tanaka, Haruo; Masuma, Rokuro; Ōmura, Satoshi. New brominated and halogen-less derivatives and structure-activity relationship of azaphilones inhibiting gp120-CD4 binding. J. Antibiot. 51(11), 1004–1011 (1998).

• 324 Namatame, Ichiji; Tomoda, Hiroshi; Si, Shuyi; Yamaguchi, Yuichi; Masuma, Rokuro; Ōmura, Satoshi. Beauveriolides, specific inhibitors of lipid droplet formation in mouse macrophages, produced by Beauveria sp. FO-6979. J. Antibiot. 52(1), 1–6 (1999).

• 325 Namatame, Ichiji; Tomoda, Hiroshi; Tabata, Noriko; Si, Shuyi; Ōmura, Satoshi. Structure elucidation of fungal beauveriolide III, a novel inhibitor of lipid droplet formation in mouse macrophages. J. Antibiot. 52(1), 7–12 (1999).

• 326 Zhang, Hua; Tomoda, Hiroshi; Tabata, Noriko; Oohori, Masako; Shinose, Mayumi; Takahashi, Yoko; Ōmura, Satoshi. Zelkovamycin, a new cyclic peptide antibiotic from Streptomyces sp. K96-0670. I. Production, isolation and biological properties. J. Antibiot. 52(1), 29–33 (1999).

• 327 Tabata, Noriko; Tomoda, Hiroshi; Zhang, Hua; Uchida, Ryuji; Ōmura, Satoshi. Zelkovamycin, a new cyclic peptide antibiotic from Streptomyces sp. K96-0670. II. Structure elucidation. J. Antibiot. 52(1), 34–39 (1999).

• 328 Ōmura, Satoshi; Enomoto, Yumi; Shinose, Mayumi; Takahashi, Yoko; Iwai, Yuzuru; Shiomi, Kazuro. Isolation and structure of a new antibiotic viridomycin F produced by Streptomyces sp. K96-0188. J. Antibiot. 52(1), 61–64 (1999).

• 329 Sunazuka, Toshiaki; Takizawa, Hajime; Desaki, Masashi; Suzuki, Kunihiko; Obata, Rika; Otoguro, Kazuhiko; Ōmura, Satoshi. Effects of erythromycin and its derivatives on interleukin-8 release by human bronchial epithelial cell line BEAS-2B cells. J. Antibiot. 52(1), 71–74 (1999).

• 330 Tomoda, Hiroshi; Matsushima, Chikako; Tabata, Noriko; Namatame, Ichiji; Tanaka, Haruo; Bamberger, Mark J.; Arai, Hiroyuki; Fukazawa, Masayoshi; Inoue, Keizo; Ōmura, Satoshi. Structure-specific inhibition of cholesteryl ester transfer protein by azaphilones. J. Antibiot. 52(2), 160–170 (1999).

• 331 Fukami, Akiko; Taniguchi, Yosuke; Nakamura, Tomonori; Rho, Mun-Chual; Kawaguchi, Kanako; Hayashi, Masahiko; Komiyama, Kanki; Ōmura, Satoshi. New members of the macrosphelides from Microsphaeropsis sp. FO-5050 IV. J. Antibiot. 52(5), 501–504 (1999).

• 332 Uchida, Ryuji; Tomoda, Hiroshi; Dong, Yuesheng; Ōmura, Satoshi. Alutenusin, a specific neutral sphingomyelinase inhibitor, produced by Penicillium sp. FO-7436. J. Antibiot. 52(6), 572–574 (1999).

• 333 Ōmura, Satoshi; Tomoda, Hiroshi; Tabata, Noriko; Ohyama, Yukako; Abe, Tatsuo; Namikoshi, Michio. Roselipins, novel fungal metabolites having a highly methylated fatty acid modified with a mannose and an arabinitol. J. Antibiot. 52(6), 586–589 (1999).

• 334 Tomoda, Hiroshi; Ohyama, Yukako; Abe, Tatsuo; Tabata, Noriko; Namikoshi, Michio; Yamaguchi, Yuichi; Masuma, Rokuro; Ōmura, Satoshi. Roselipins, inhibitors of diacylglycerol acyltransferase, produced by Gliocladium roseum KF-1040. J. Antibiot. 52(8), 689–694 (1999).

• 335 Matsumoto, Tsukasa; Ishiyama, Aki; Yamaguchi, Yuuichi; Masuma, Rokuro; Ui, Hideaki; Shiomi, Kazuro; Yamada, Haruki; Ōmura, Satoshi. Novel cyclopentanone derivatives pentenocins A and B, with interleukin-1β converting enzyme inhibitory activity, produced by Trichoderma hamatum FO-6903. J. Antibiot. 52(8), 754–757 (1999),.

• 336 Tabata, Noriko; Ohyama, Yukako; Tomoda, Hiroshi; Abe, Tatsuo; Namikoshi, Michio; Ōmura, Satoshi. Structure elucidation of roselipins, inhibitors of diacylglycerol acyltransferase produced by Gliocladium roseum KF-1040. J. Antibiot. 52(9), 815–826 (1999).

• 337 Tomoda, Hiroshi; Namatame, Ichiji; Si, Shuyi; Kawaguchi, Kotaro; Masuma, Rokuro; Namikoshi, Michio; Ōmura, Satoshi. Phenochalasins, inhibitors of lipid droplet formation in mouse macrophages, produced by Phomopsis sp. FT-0211. J. Antibiot. 52(10), 851–856 (1999).

• 338 Tomoda, Hiroshi; Namatame, Ichiji; Tabata, Noriko; Kawaguchi, Kotaro; Si, Shuyi; Ōmura, Satoshi. Structure elucidation of fungal phenochalasins, novel inhibitors of lipid droplet formation in mouse macrophages. J. Antibiot. 52(10), 857–861 (1999).

• 339 Tanaka, Yoshitake; Kamei, Kiseko; Otoguro, Kazuhiko; Ōmura, Satoshi. Heme-dependent radical generation. possible involvement in antimalarial action of non-peroxide microbial metabolites, nanomycin A and radicicol. J. Antibiot. 52(10), 880–888 (1999).

• 340 Tabata, Noriko; Tomoda, Hiroshi; Yamaguchi, Yuichi; Masuma, Rokuro; Bamberger, Mark J.; Ōmura, Satoshi. Inhibition of cholesteryl ester transfer protein by fungal metabolites, L681,512. J. Antibiot. 52(11), 1042–1045 (1999).

• 341 Sztaricskai, Ferenc; Batta, Gyula; Dinya, Zoltan; Hornyak, Miklos; Roth, Erzsebet; Masuma, Rokuro; Ōmura, Satoshi. Structural modification of the lincomycin antibiotic. J. Antibiot. 52(11), 1050–1055 (1999).

• 342 Inokoshi, Junji; Shiomi, Kazuro; Masuma, Rokuro; Tanaka, Haruo; Yamada, Haruki; Ōmura, Satoshi. Funalenone, a novel collagenase inhibitor produced by Aspergillus niger. J. Antibiot. 52(12), 1095–1100 (1999).

• 343 Tomoda, Hiroshi; Tabata, Noriko; Shinose, Mayumi; Takahashi, Yoko; Woodruff, H. Boyd; Ōmura, Satoshi. Ferroverdins, inhibitors of cholesteryl ester transfer protein produced by Streptomyces sp. WK-5344. I. Production, isolation and biological properties. J. Antibiot. 52(12), 1101–1107 (1999).

• 344 Tabata, Noriko; Tomoda, Hiroshi; Ōmura, Satoshi. Ferroverdins, inhibitors of cholesteryl ester transfer protein produced by Streptomyces sp. WK-5344. II. Structure elucidation. J. Antibiot. 52(12), 1108–1113 (1999).

• 345 Namatame, Ichiji; Tomoda, Hiroshi; Arai, Masayoshi; Ōmura, Satoshi. Effect of fungal metabolites cytochalasans on lipid droplet formation in mouse macrophages. J. Antibiot. 53(1), 19–25 (2000).

• 346 Otoguro, Kazuhiko; Shiomi, Kazuro; Yamaguchi, Yuuichi; Arai, Noriko; Sunazuka, Toshiaki; Masuma, Rokuro; Iwai, Yuzuru; Ōmura, Satoshi. Arisugacins C and D, novel acetylcholinesterase inhibitors and their related novel metabolites produced by Penicillium sp. FO-4259-11. J. Antibiot. 53(1), 50–57 (2000).

• 347 Obata, Rika; Sunazuka, Toshiaki; Harigaya, Yoshihiro; Rho, Mun-Chual; Tomoda, Hiroshi; Ōmura, Satoshi. Structure-activity relationships study of pyripyropenes: reversal of cancer cell multidrug resistance. J. Antibiot. 53(4), 422–425 (2000).

• 348 Li, Zhuorong; Sunazuka, Toshiaki; Yamada, Rintaro; Kato, Yumiko; Enomoto, Akiko; Hayashi, Masahiko; Harigaya, Yoshihiro; Ōmura, Satoshi. Synthesis and antiangiogenic activity of staurosporine derivatives. J. Antibiot. 53(4), 426–429 (2000).

• 349 Ōmura, Satoshi; Arai, Noriko; Yamaguchi, Yuuichi; Masuma, Rokuro; Iwai, Yuzuru; Namikoshi, Michio; Turberg, Andreas; Kolbl, Heinz; Shiomi, Kazuro. Argifin, a new chitinase inhibitor, produced by Gliocladium sp. FTD-0668. I. Taxonomy, fermentation, and biological activities. J. Antibiot. 53(6), 603–608 (2000).

• 350 Arai, Noriko; Shiomi, Kazuro; Iwai, Yuzuru; Ōmura, Satoshi. Argifin, a new chitinase inhibitor, produced by Gliocladium sp. FTD-0668. II. Isolation, physico-chemical properties, and structure elucidation. J. Antibiot. 53(6), 609–614 (2000).

• 351 Rho, Mun-Chual; Hayashi, Masahiko; Fukami, Akiko; Obata, Rika; Sunazuka, Toshiaki; Tomoda, Hiroshi; Komiyama, Kanki; Ōmura, Satoshi. Reversal of multidrug resistance by 7- O -benzoylpyripyropene A in multidrug-resistant tumor cells. J. Antibiot. 53(10), 1201–1206 (2000).

• 352 Fukami, Akiko; Nakamura, Tomonori; Kawaguchi, Kanako; Rho, Mun-Chual; Matsumoto, Atsuko; Takahashi, Yoko; Shiomi, Kazuro; Hayashi, Masahiko; Komiyama, Kanki; Ōmura, Satoshi. A new antimicrobial antibiotic from Actinoplanescapillaceus sp. K95-5561^T. J. Antibiot. 53(10), 1212–1214 (2000).

• 353 Fukami, Akiko; Nakamura, Tomonori; Kim, Yong-Pil; Shiomi, Kazuro; Hayashi, Masahiko; Nagai, Takayuki; Yamada, Haruki; Komiyama, Kanki; Ōmura, Satoshi. A new anti-influenza virus antibiotic, 10-norparvulenone from Microsphaeropsis sp. FO-5050. J. Antibiot. 53(10), 1215–1218 (2000).

• 354 Oohori, Masako; Otoguro, Kazuhiko; Sunazuka, Toshiaki; Kunihiko, Suzuki; Iwai, Yuzuru; Ōmura, Satoshi. Effect of 14-membered ring macrolide compounds on rat leucocyte chemotaxis and the structure-activity relationships. J. Antibiot. 53(10), 1219–1222 (2000).

• 355 Ui, Hideaki; Shiomi, Kazuro; Yamaguchi, Yuuichi; Masuma, Rokuro; Nagamitsu, Tohru; Takano, Daisuke; Sunazuka, Toshiaki; Namikoshi, Michio; Ōmura, Satoshi. Nafuredin, a novel inhibitor of NADH-fumarate reductase, produced by Aspergillus niger FT-0554. J. Antibiot. 54(3), 234–238 (2001).

• 356 Enomoto, Yumi; Shiomi, Kazuro; Matsumoto, Atsuko; Takahashi, Yoko; Iwai, Yuzuru; Harder, Achim; Kolbl, Heinz; Woodruff, H. Boyd; Ōmura, Satoshi. Isolation of a new antibiotic oligomycin G produced by Streptomyces sp. WK-6150. J. Antibiot. 54(3), 308–313 (2001).

• 357 Handa, Masaki; Sunazuka, Toshiaki; Nagai, Kenichiro; Kumura, Ryouko; Shirahata, Tatsuya; Tian, Zhi-Ming; Otoguro, Kazuhiko; Harigaya, Yoshihiro; Ōmura, Satoshi. Convergent synthesis of arisugacin skeletons and their acetylcholinesterase inhibitory activity. J. Antibiot. 54(4), 382–385 (2001).

• 358 Handa, Masaki; Sunazuka, Toshiaki; Nagai, Kenichiro; Kimura, Ryouko; Otoguro, Kazuhiko; Harigaya, Yoshihiro; Ōmura, Satoshi. Determination of absolute stereochemistries of arisugacin F and territrem B, novel acetylcholinesterase inhibitors. J. Antibiot. 54(4), 386–391 (2001).

• 359 Arai, Masayoshi; Tomoda, Hiroshi; Matsumoto, Atsuko; Takahashi, Yoko; Woodruff, Body H.; Ishiguro, Nobiko; Kobayashi, Susumu; Ōmura, Satoshi. Deacetylravidomycin M, a new inhibitor of IL-4 signal transduction, produced by Streptomyces sp. WK-6326. I. Taxonomy, fermentation, isolation and biological activities. J. Antibiot. 54(7), 554–561 (2001).

• 360 Arai, Masayoshi; Tomoda, Hiroshi; Tabata, Noriko; Ishiguro, Nobiko; Kobayashi, Susumu; Ōmura, Satoshi. Deacetylravidomycin M, a new inhibitor of IL-4 signal transduction, produced by Streptomyces sp. WK-6326. II. Structure elucidation. J. Antibiot. 54(7), 562–566 (2001),.

• 361 Zhang, Hua; Tomoda, Hiroshi; Tabata, Noriko; Miura, Hiromi; Namikoshi, Michio; Yamaguchi, Yuichi; Masuma, Rokuro; Ōmura, Satoshi. Cladospolide D, a new 12-membered macrolide antibiotic produced by Cladosporium sp. FT-0012. J. Antibiot. 54(8), 635–641 (2001).

• 362 Otoguro, Kazuhiko; Kohana, Akiko; Manabe, Chizu; Ishiyama, Aki; Ui, Hideaki; Shiomi, Kazuro; Yamada, Haruki; Ōmura, Satoshi. Potent antimalarial activities of polyether antibiotic, X-206. J. Antibiot. 54(8), 658–663 (2001).

• 363 Chiba, Harumi; Asanuma, Satoshi; Okamoto, Megumi; Inokoshi, Junji; Tanaka, Haruo; Fujita, Kazunobu; Ōmura, Satoshi. A simple screening system for anti-HIV drugs: syncytium formation assay using T-cell line tropic and macrophage tropic HIV env expressing cell lines-establishment and validation. J. Antibiot. 54(10), 818–826 (2001).

• 364 Uchida, Ryuji; Tomoda, Hiroshi; Arai, Masayoshi; Ōmura, Satoshi. Chlorogentisylquinone, a new neutral sphingomyelinase inhibitor, produced by a marine fungus. J. Antibiot. 54(11), 882–889 (2001).

• 365 Arai, Masayoshi; Tomoda, Hiroshi; Okuda, Takako; Wang, Haiyan; Tabata, Noriko; Masuma, Rokuro; Yamaguchi, Yuichi; Ōmura, Satoshi. Funicone-related compounds, potentiators of antifungal miconazole activity, produced by Talaromycesflavus FKI-0076. J. Antibiot. 55(2), 172–180 (2002).

• 366 Otoguro, Kazuhiko; Ishiyama, Aki; Ui, Hideaki; Kobayashi, Miyuki; Manabe, Chizu; Yan, Guan; Takahashi, Yoko; Tanaka, Haruo; Yamada, Haruki; Ōmura, Satoshi. In vitro and in vivo antimalarial activities of the monoglycoside polyether antibiotic, K-41 against drug resistant strains of Plasmodia. J. Antibiot. 55(9), 832–834 (2002).

• 367 Shiomi, Kazuro; Hatae, Kenji; Yamaguchi, Yuichi; Masuma, Rokuro; Tomoda, Hiroshi; Kobayashi, Susumu; Ōmura, Satoshi. New antibiotics miyakamides produced by a fungus. J. Antibiot. 55(11), 952–961 (2002).

• 368 Namatame, Ichiji; Matsuda, Daisuke; Tomoda, Hiroshi; Yamaguchi, Yuichi; Masuma, Rokuro; Kobayashi, Susumu; Ōmura, Satoshi. Selective production of fungal beauveriolide I or III by fermentation in amino acid-supplemented media. J. Antibiot. 55(12), 1048–1052 (2002).

• 369 Tomoda, Hiroshi; Tabata, Noriko; Ohyama, Yukako; Ōmura, Satoshi. Core structure in roselipins essential for eliciting inhibitory activity against diacylglycerol acyltransferase. J. Antibiot. 56(1), 24–29 (2003).

• 370 Otoguro, Kazuhiko; Ui, Hideaki; Ishiyama, Aki; Arai, Noriko; Kobayashi, Miyuki; Takahashi, Yoko; Masuma, Rokuro; Shiomi, Kazuro; Yamada, Haruki; Ōmura, Satoshi. In vitro antimalarial activities of the microbial metabolites. J. Antibiot. 56(3), 322–324 (2003).

• 371 Kim, Yong-Pil; Tomoda, Hiroshi; Iizima, Kousuke; Fukuda, Takashi; Matsumoto, Atsuko; Takahashi, Yoko; Ōmura, Satoshi. Takanawaenes, novel antifungal antibiotics produced by Streptomyces sp. K99-5278. I. Taxonomy, fermentation, isolation and biological properties. J. Antibiot. 56(5), 448–453 (2003).

• 372 Fukuda, Takashi; Kim, Yong-Pil; Iizima, Kousuke; Tomoda, Hiroshi; Ōmura, Satoshi. Takanawaenes, novel antifungal antibiotics produced by Streptomyces sp. K99-5278. II. Structure elucidation. J. Antibiot. 56(5), 454–458 (2003).

• 373 Arai, Masayoshi; Yamamoto, Kazunobu; Namatame, Ichiji; Tomoda, Hiroshi; Ōmura, Satoshi. New monordens produced by amidepsine-producing fungus Humicola sp. FO-2942. J. Antibiot. 56(6), 526–532 (2003).

• 374 Yamamoto, Kazunobu; Hatano, Hiroko; Arai, Masayoshi; Shiomi, Kazuro; Tomoda, Hiroshi; Ōmura, Satoshi. Structure elucidation of new monordens produced by Humicola sp. FO-2942. J. Antibiot. 56(6), 533–538 (2003).

• 375 Sunazuka, Toshiaki; Yoshida, Kiminari; Oohori, Masako; Otoguro, Kazuhiko; Harigaya, Yoshihiro; Iwai, Yuzuru; Akagawa, Kiyoko S.; Ōmura, Satoshi. Effect of 14-membered macrolide compounds on monocyte to macrophage differentiation. J. Antibiot. 56(8), 721–724 (2003).

• 376 Otoguro, Kazuhiko; Ui, Hideaki; Ishiyama, Aki; Kobayashi, Miyuki; togashi, Hideaki; Takahashi, Yoko; Masuma, Rokuro; Tanaka, Haruo; Tomoda, Hiroshi; Yamada, Haruki; Ōmura, Satoshi. In vitro and in vivo antimalarial activities of a non-glycosidic 18-membered macrolide antibiotic, borrelidin, against drug-resistant strains of Plasmodia. J. Antibiot. 56(8), 727–729 (2003).

• 377 Handa, Masaki; Sunazuka, Toshiaki; Sugawara, Akihiro; Harigaya, Yoshihiro; Otoguro, Kazuhiko; Ōmura, Satoshi. Total syntheses of the AChE inhibitors (±)-arisugacins F and G. J. Antibiot. 56(8), 730–733 (2003).

• 378 Sakano, Yuichi; Shibuya, Masaaki; Matsumoto, Atsuko; Takahashi, Yoko; Tomoda, Hiroshi; Ōmura, Satoshi; Ebizuka, Yutaka. Lanopylins A₁, B₁, A₂ and B₂, novel lanosterol synthase inhibitors from Streptomyces sp. K99-5041. J. Antibiot. 56(10), 817–826 (2003).

• 379 Matsuda, Daisuke; Namatame, Ichiji; Tomoda, Hiroshi; Kobayashi, Susumu; Zocher, Rainer; Kleinkauf, Horst; Ōmura, Satoshi. New beauveriolides produced by amino acid-supplemented fermentation of Beauveria sp. FO-6979. J. Antibiot. 57(1), 1–9 (2004).

• 380 Fukuda, Takashi; Arai, Masayoshi; Yamaguchi, Yuichi; Masuma, Rokurou; Tomoda, Hiroshi; Ōmura, Satoshi. New beauvericins, potentiators of antifungal miconazole activity, produced by Beauveria sp. FKI-1366. I. Taxonomy, fermentation, isolation and biological properties. J. Antibiot. 57(2), 110–116 (2004).

• 381 Fukuda, Takashi; Arai, Masayoshi; Tomoda, Hiroshi; Ōmura, Satoshi. New beauvericins, potentiators of antifungal miconazole activity, produced by Beauveria sp. FKI-1366. II. Structure elucidation. J. Antibiot. 57(2), 117–124 (2004).

• 382 Otoguro, Kazuhiko; Ishiyama, Aki; Kobayashi, Miyuki; Sekiguchi, Hitomi; Izuhara, Takashi; Sunazuka, Toshiaki; Tomoda, Hiroshi; Yamada, Haruki; Ōmura, Satoshi. In vitro and in vivo antimalarial activities of a carbohydrate antibiotic, prumycin, against drug-resistant strains of Plasmodia. J. Antibiot. 57(6), 400–402 (2004).

• 383 Koizumi, Yukio; Arai, Masayoshi; Tomoda, Hiroshi; Ōmura, Satoshi. Fungerin, a fungal alkaloid, arrests the cell cycle in M phase by inhibition of microtubule polymerization. J. Antibiot. 57(7), 415–420 (2004).

• 384 Sakano, Yuichi; Shibuya, Masaaki; Yamaguchi, Yuichi; Masuma, Rokuro; Tomoda, Hiroshi; Ōmura, Satoshi; Ebizuka, Yutaka. Epohelmins A and B, novel lanosterol synthase inhibitors from a fungal strain FKI-0929. J. Antibiot. 57(9), 564–568 (2004).

• 385 Arai, Masayoshi; Koizumi, Yukio; Sato, Hitoshi; Kawabe, Takumi; Suganuma, Masashi; Kobayashi, Hidetaka; Tomoda, Hiroshi; Ōmura, Satoshi. Boromycin abrogates bleomycin-induced G2 checkpoint. J. Antibiot. 57(10), 662–668 (2004).

• 386 Shiomi, Kazuro; Ui, Hideaki; Suzuki, Hideaki; Hatano, Hiroko; Nagamitsu, Tohru; Takano, Daisuke; Miyadera, Hiroko; Yamashita, Tetsuo; Kita, Kiyoshi; Miyoshi, Hideto; Harder, Achim; Tomoda, Hiroshi; Ōmura, Satoshi. A γ-lactone form nafuredin, nafuredin-γ, also inhibits helminth complex I. J. Antibiot. 58(1), 50–55 (2005).

• 387 Shiomi, Kazuro; Matsui, Ryosuke; Isozaki, Miki; Chiba, Harumi; Sugai, Takahiro; Yamaguchi, Yuichi; Masuma, Rokuro; Tomoda, Hiroshi; Chiba, Tomoko; Yan, Hua; Kitamura, Yoshihiro; Sugiura, Wataru; Ōmura, Satoshi; Tanaka, Haruo. Fungal phenalenones inhibit HIV-1 integrase. J. Antibiot. 58(1), 65–68 (2005).

• 388 Shiomi, Kazuro; Hatae, Kenji; Hatano, Hiroko; Matsumoto, Atsuko; Takahashi, Yoko; Jiang, Cheng-Lin; Tomoda, Hiroshi; Kobayashi, Susumu; Tanaka, Haruo; Ōmura, Satoshi. A new antibiotic, antimycin A₉, produced by Streptomyces sp. K01-0031. J. Antibiot. 58(1), 74–78 (2005).

• 389 Yoshida, Kiminari; Sunazuka, Toshiaki; Nagai, Kenichiro; Sugawara, Akihiro; Cho, Achim; Nagamitsu, Tohru; Harigaya, Yoshihiro; Otoguro, Kazuhiko; Akagawa, Kiyoko S.; Ōmura, Satoshi. Macrolides with promotive activity of monocyte to macrophage differentiation. J. Antibiot. 58(1), 79–81 (2005).

• 390 Fukuda, Takashi; Matsumoto, Atsuko; Takahashi, Yoko; Tomoda, Hiroshi; Ōmura, Satoshi. Phenatic acids A and B, new potentiators of antifungal miconazole activity produced by Streptomyces sp. K03-0132. J. Antibiot. 58(4), 252–259 (2005).

• 391 Fukuda, Takashi; Yamaguchi, Yuichi; Masuma, Rokuro; Tomoda, Hiroshi; Ōmura, Satoshi. Citridones, new potentiators of antifungal miconazole activity, produced by Penicillium sp. FKI-1938. I. Taxonomy, fermentation, isolation and biological properties. J. Antibiot. 58(5), 309–314 (2005).

• 392 Fukuda, Takashi; Tomoda, Hiroshi; Ōmura, Satoshi. Citridones, new potentiators of antifungal miconazole activity, produced by Penicillium sp. FKI-1938. II. Structure elucidation. J. Antibiot. 58(5), 315–321 (2005).

• 393 Koyama, Nobuhiro; Nagahiro, Tomoko; Yamaguchi, Yuichi; Ohshiro, Taichi; Masuma, Rokuro; Tomoda, Hiroshi; Ōmura, Satoshi. Spylidone, a novel inhibitor of lipid droplet accumulation in mouse macrophages produced by Phoma sp. FKI-1840. J. Antibiot. 58(5), 338–345 (2005).

• 394 Uchida, Ryuji; Imasato, Rie; Yamaguchi, Yuichi; Masuma, Rokuro; Shiomi, Kazuro; Tomoda, Hiroshi; Ōmura, Satoshi. New sesquicillins, insecticidal antibiotics produced by Albophoma sp. FKI-1778. J. Antibiot. 58(6), 397–404 (2005).

• 395 Ui, Hideaki; Asanuma, Satoshi; Chiba, Harumi; Takahashi, Atsushi; Yamaguchi, Yuichi; Masuma, Rokuro; Ōmura, Satoshi; Tanaka, Haruo. Mycophenolic acid inhibits syncytium formation accompanied by reduction of gp120 expression. J. Antibiot. 58(8), 514–518 (2005).

• 396 Shibuya, Masaaki; Snider, Barry B.; Sakano, Yuichi; Tomoda, Hiroshi; Ōmura, Satoshi; Ebizuka, Yutaka. Revised structures of epohelmins A and B isolated as lanosterol synthase inhibitors from a fungal strain FKI-0929. J. Antibiot. 58(9), 599–601 (2005).

• 397 Koyama, Nobuhiro; Nagahiro, Tomoko; Yamaguchi, Yuichi; Masuma, Rokuro; Tomoda, Hiroshi; Ōmura, Satoshi. Stemphones, novel potentiators of imipenem activity against methicillin-resistant Staphylococcus aureus, produced by Aspergillus sp. FKI-2136. J. Antibiot. 58(11), 695–703 (2005).

• 398 Uchida, Ryuji; Imasato, Rie; Yamaguchi, Yuichi; Masuma, Rokuro; Shiomi, Kazuro; Tomoda, Hiroshi; Ōmura, Satoshi. New insecticidal antibiotics, hydroxyfungerins A and B, produced by Metarhizium sp. FKI-1079. J. Antibiot. 58 (12), 804–809 (2005).

• 399 Uchida, Ryuji; Kim, Yong-Pil; Namatame, Ichiji; Tomoda, Hiroshi; Ōmura, Satoshi. Sespendole, a new inhibitor of lipid droplet synthesis in macrophages, produced by Pseudobotrytis terrestris FKA-25. J. Antibiot. 59(2), 93–97 (2006).

• 400 Banskota, Arjun H.; McAlpine, James B.; Sorensen, Dan; Aouidate, Mustapha; Piraee, Mahmood; Alarco, Anne-Marie; Ōmura, Satoshi; Shiomi, Kazuro; Farnet, Chris M.; Zazopoulos, Emmanuel. Isolation and identification of three new 5-alkenyl-3,3 (2H)-furanones from two Streptomyces species using a genomic screening approach. J. Antibiot. 59(3), 168–176 (2006).

• 401 Uchida, Ryuji; Tomoda, Hiroshi; Ōmura, Satoshi. Biosynthesis of sespendole. J. Antibiot. 59(5), 298–302 (2006).

• 402 Uchida, Ryuji; Kim, Yong-Pil; Nagamitsu, Tohru; Tomoda, Hiroshi; Ōmura, Satoshi. Structure elucidation of fungal sespendole, an inhibitor of lipid droplet synthesis in macrophages. J. Antibiot. 59(6), 338–344 (2006).

• 403 Cane, David E.; He, Xiaofei; Kobayashi, Seiji; Ōmura, Satoshi; Ikeda, Haruo. Geosmin biosynthesis in Streptomyces avermitilis. Molecular cloning, expression, and mechanistic study of the germacradienol/geosmin synthase. J. Antibiot. 59(8), 471–479 (2006).

• 404 Fukuda, Takashi; Hasegawa, Yoko; Hagimori, Keiichi; Yamaguchi, Yuichi; Masuma, Rokuro; Tomoda, Hiroshi; Ōmura, Satoshi. Tensidols, new potentiators of antifungal miconazole activity, produced by Aspergillus niger FKI-2342. J. Antibiot. 59(8), 480–485 (2006).

• 405 Ui, Hideaki; Shiomi, Kazuro; Suzuki, Hideaki; Hatano, Hiroko; Morimoto, Hiromi; Yamaguchi, Yuichi; Masuma, Rokuro; Sakamoto, Kimitoshi; Kita, Kiyoshi; Miyoshi, Hideto; Tomoda, Hiroshi; Tanaka, Haruo; Ōmura, Satoshi. Paecilaminol, a new NADH-fumarate reductase inhibitor, produced by Paecilomyces sp. FKI-0550. J. Antibiot. 59(9), 591–596 (2006).

• 406 Uchida, Ryuji; Imasato, Rie; Yamaguchi, Yuichi; Masuma, Rokuro; Shiomi, Kazuro; Tomoda, Hiroshi; Ōmura, Satoshi. Yaequinolones, new insecticidal antibiotics produced by Penicillium sp. FKI-2140. I. Taxonomy, fermentation, isolation and biological activity. J. Antibiot. 59(10), 646–651 (2006).

• 407 Uchida, Ryuji; Imasato, Rie; Tomoda, Hiroshi; Ōmura, Satoshi. Yaequinolones, new insecticidal antibiotics produced by Penicillium sp. FKI-2140. II. Structural elucidation. J. Antibiot. 59(10), 652–658 (2006).

• 408 Ui, Hideaki; Shiomi, Kazuro; Suzuki, Hideaki; Hatano, Hiroko; Morimoto, Hiromi; Yamaguchi, Yuichi; Masuma, Rokuro; Sunazuka, Toshiaki; Shimamura, Hiroyuki; Sakamoto, Kimitoshi; Kita, Kiyoshi; Miyoshi, Hideto; Tomoda, Hiroshi; Ōmura, Satoshi. Verticipyrone, a new NADH-fumarate reductase inhibitor, produced by Verticillium sp. FKI-1083. J. Antibiot. 59(12), 785–790 (2006).

• 409 Iwasaki, Shigeo; Ōmura, Satoshi. Search for protein farnesyltransferase inhibitors of microbial origin: our strategy and results as well as the results obtained by other groups. J. Antibiot. 60(1), 1–12 (2007).

• 410 Ohshiro, Taichi; Rudel, Lawrence L.; Ōmura, Satoshi; Tomoda, Hiroshi. Selectivity of microbial acyl-CoA: cholesterol acyltransferase inhibitors toward isozymes. J. Antibiot. 60(1), 43–51 (2007).

• 411 Ui, Hideaki; Ishiyama, Aki; Sekiguchi, Hitomi; Namatame, Miyuki; Nishihara, Aki; Takahashi, Yoko; Shiomi, Kazuro; Otoguro, Kazuhiko; Ōmura, Satoshi. Selective and potent in vitro antimalarial activities found in four microbial metabolites. J. Antibiot. 60(3), 220–222 (2007).

• 412 Iwatsuki, Masato; Uchida, Ryuji; Takakusagi, Yoichi; Matsumoto, Atsuko; Jiang, Cheng-Lin; Takahashi, Yoko; Arai, Masayoshi; Kobayashi, Susumu; Matsumoto, Makoto; Inokoshi, Junji; Tomoda, Hiroshi; Ōmura, Satoshi. Lariatins, novel anti-mycobacterial peptides with a lasso structure, produced by Rhodococcus jostii K01-B0171. J. Antibiot. 60(6), 357–363 (2007).

• 413 Fukumoto, Atsushi; Kim, Yong-Pil; Matsumoto, Atsuko; Takahashi, Yoko; Shiomi, Kazuro; Tomoda, Hiroshi; Ōmura, Satoshi. Cyslabdan, a new potentiator of imipenem activity against methicillin-resistant Staphylococcus aureus, produced by Streptomyces sp. K04-0144. I. Taxonomy, fermentation, isolation and structural elucidation. J. Antibiot. 61(1), 1–6 (2008).

• 414 Fukumoto, Atsushi; Kim, Yong-Pil; Hanaki, Hideaki; Shiomi, Kazuro; Tomoda, Hiroshi; Ōmura, Satoshi. Cyslabdan, a new potentiator of imipenem activity against Methicillin-resistant Staphylococcus aureus, produced by Streptomyces sp. K04-0144. II. Biological activities. J. Antibiot. 61(1), 7–10 (2008).

• 415 Sunazuka, Toshiaki; Shudo, Hiroko; Nagai, Kenichiro; Yoshida, Kiminari; Yamaguchi, Yukie; Hanaki, Hideaki; Ōmura, Satoshi. 4'''- N -demethylspiramycin derivatives: synthesis and evaluation of effectiveness against drug-resistant bacteria. J. Antibiot. 61(3), 175–184 (2008).

• 416 Iwatsuki, Masato; Uchida, Ryuji; Yoshijima, Hitomi; Ui, Hideaki; Shiomi, Kazuro; Matsumoto, Atsuko; Takahashi, Yoko; Abe, Akio; Tomoda, Hiroshi; Ōmura, Satoshi. Guadinomines, type III secretion system inhibitors, produced by Streptomyces sp. K01-0509. I. Taxonomy, fermentation, isolation and biological properties. J. Antibiot. 61(4), 222–229 (2008).

• 417 Iwatsuki, Masato; Uchida, Ryuji; Yoshijima, Hitomi; Ui, Hideaki; Shiomi, Kazuro; Kim, Yong-Pil; Hirose, Tomoyasu; Sunazuka, Toshiaki; Abe, Akio; Tomoda, Hiroshi; Ōmura, Satoshi. Guadinomines, type III secretion system inhibitors, produced by Streptomyces sp. K01-0509. II. Physico-chemical properties and structure elucidation. J. Antibiot. 61(4), 230–236 (2008).

• 418 Ishiyama, Aki; Otoguro, Kazuhiko; Namatame, Miyuki; Nishihara, Aki; Furusawa, Toshiaki; Takahashi, Yoko; Masuma, Rokuro; Shiomi, Kazuro; Ōmura, Satoshi. Simaomicin α: effects on the cell cycle of synchronized, cultured Plasmodium falciparum. J. Antibiot. 61(4), 254–257 (2008).

• 419 Kojima, Yasuhiro; Sunazuka, Toshiaki; Nagai, Kenichiro; Julfakyan, Khachatur; Fukuda, Takashi; Tomoda, Hiroshi; Ōmura, Satoshi: total synthesis of malformin C, an inhibitor of bleomycin-induced G2 arrest. J. Antibiot. 61(5), 297–302 (2008).

• 420 Matsuda, Daisuke; Namatame, Ichiji; Ohshiro, Taichi; Ishibashi, Shun; Ōmura, Satoshi; Tomoda, Hiroshi. Anti-atherosclerotic activity of triacsin C, an acyl-CoA synthetase inhibitor. J. Antibiot. 61(5), 318–321 (2008).

• 421 Otoguro, Kazuhiko; Ishiyama, Aki; Namatame, Miyuki; Nishihara, Aki; Furusawa, Toshiaki; Masuma, Rokuro; Shiomi, Kazuro; Takahashi, Yoko; Yamada, Haruki; Ōmura, Satoshi. Selective and potent in vitro antitrypanosomal activities of ten microbial metabolites. J. Antibiot. 61(6), 372–378 (2008).

• 422 Yamazaki, Hiroyuki; Koyama, Nobuhiro; Ōmura, Satoshi; Tomoda, Hiroshi. Structure-activity relationships of stemphones, potentiators of imipenem activity against methicillin-resistant Staphylococcus aureus. J. Antibiot. 61(7), 426–441 (2008).

• 423 Ohshiro, Taichi; Ohte, Satoshi; Matsuda, Daisuke; Ohtawa, Masaki; Nagamitsu, Tohru; Sunazuka, Toshiaki; Harigaya, Yoshihiro; Rudel, Lawrence L.; Ōmura, Satoshi; Tomoda, Hiroshi. Selectivity of pyripyropene derivatives in inhibition toward acyl-CoA: cholesterol acyltransferase 2 isozyme. J. Antibiot. 61(8), 503–508 (2008).

• 424 Fukuda, Takashi; Hasegawa, Yoko; Sakabe, Yasunari; Tomoda, Hiroshi; Ōmura, Satoshi. Citrinamides, new potentiators of antifungal miconazole activity, produced by Penicillium sp. FKI-1938. J. Antibiot. 61(9), 550–555 (2008).

• 425 Ishiyama, Aki; Otoguro, Kazuhiko; Namatame, Miyuki; Nishihara, Aki; Furusawa, Toshiaki; Masuma, Rokuro; Shiomi, Kazuro; Takahashi, Yoko; Ichimura, Michio; Yamada, Haruki; Ōmura, Satoshi. In vitro and in vivo antitrypanosomal activity of two microbial metabolites, KS-505a and alazopeptin. J. Antibiot. 61(10), 627–632 (2008).

• 426 Nakano, Hirofumi; Ōmura, Satoshi. Chemical biology of natural indolocarbazole products: 30 years since the discovery of staurosporine. J. Antibiot. 62(1), 17–26 (2009).

• 427 Inokoshi, Junji; Kawamoto, Kyosuke; Takagi, Yoichi; Matsuhama, Maki; Ōmura, Satoshi; Tomoda, Hiroshi. Expression of two human acyl-CoA: diacylglycerol acyltransferase isozymes in yeast and selectivity of microbial inhibitors toward the isozymes. J. Antibiot. 62(1), 51–54 (2009).

• 428 Nagamitsu, Tohru; Marumoto, Kaori; Nagayasu, Asami; Fukuda, Takeo; Arima, Shiho; Uchida, Ryuji; Ohshiro, Taichi; Harigaya, Yoshihiro; Tomoda, Hiroshi; Ōmura, Satoshi. Total synthesis of amidepsine B and revision of its absolute configuration. J. Antibiot. 62(2), 69–74 (2009).

• 429 Yamazaki, Hiroyuki; Kobayashi, Kakeru; Matsuda, Daisuke; Nonaka, Kenichi; Masuma, Rokuro; Ōmura, Satoshi; Tomoda, Hiroshi. Pentacecilides, new inhibitors of lipid droplet formation in mouse macrophages, produced by Penicillium cecidicola FKI-3765-1: I. Taxonomy, fermentation, isolation and biological properties. J. Antibiot. 62(4), 195–200 (2009).

• 430 Yamazaki, Hiroyuki; Ōmura, Satoshi; Tomoda, Hiroshi. Pentacecilides, new inhibitors of lipid droplet formation in mouse macrophages produced by Penicillium cecidicola FKI-3765-1: II. Structure elucidation. J. Antibiot. 62(4), 207–211 (2009).

• 431 Hirose, Tomoyasu; Sunazuka, Toshiaki; Sugawara, Akihiro; Endo, Ayako; Iguchi, Kanami; Yamamoto, Tsuyoshi; Ui, Hideaki; Shiomi, Kazuro; Watanabe, Takeshi; Sharpless, K. Barry; Ōmura, Satoshi. Chitinase inhibitors: extraction of the active framework from natural argifin and use of in situ click chemistry. J. Antibiot. 62(5), 277–282 (2009).

• 432 Ohtawa, Masaki; Ogihara, Satoru; Sugiyama, Kouhei; Shiomi, Kazuro; Harigaya, Yoshihiro; Nagamitsu, Tohru; Ōmura, Satoshi. Enantioselective total synthesis of atpenin A5. J. Antibiot. 62(6), 289–294 (2009).

• 433 Ishiyama, Aki; Otoguro, Kazuhiko; Iwatsuki, Masahito; Namatame, Miyuki; Nishihara, Aki; Nonaka, Kenichi; Kinoshita, Yuta; Takahashi, Yoko; Masuma, Rokuro; Shiomi, Kazuro; Yamada, Haruki; Ōmura, Satoshi. In vitro and in vivo antitrypanosomal activities of three peptide antibiotics: leucinostatin A and B, alamethicin I and tsushimycin. J. Antibiot. 62(6), 303–308 (2009).

• 434 Yamazaki, Hiroyuki; Nonaka, Kenichi; Masuma, Rokuro; Ōmura, Satoshi; Tomoda, Hiroshi. Xanthoradones, new potentiators of imipenem activity against methicillin-resistant Staphylococcus aureus, produced by Penicillium radicum FKI-3765-2: I. Taxonomy, fermentation, isolation and biological properties. J. Antibiot. 62(8), 431–434 (2009).

• 435 Yamazaki, Hiroyuki; Ōmura, Satoshi; Tomoda, Hiroshi. Xanthoradones, new potentiators of imipenem activity against methicillin-resistant Staphylococcus aureus, produced by Penicillium radicum FKI-3765-2: II. Structure elucidation. J. Antibiot. 62(8), 435–437 (2009).

• 436 Hirose, Tomoyasu; Sunazuka, Toshiaki; Sugawara, Akihiro; Noguchi, Yoshihiko; Tanaka, Toshiaki; Iguchi, Kanami; Yamamoto, Tsuyoshi; Gouda, Hiroaki; Shiomi, Kazuro; Ōmura, Satoshi. Solid-phase total synthesis of the chitinase inhibitor Argadin using a supported acetal resin. J. Antibiot. 62(9), 495–500 (2009).

• 437 Kojima, Yasuhiro; Sunazuka, Toshiaki; Nagai, Kenichiro; Hirose, Tomoyasu; Namatame, Miyuki; Ishiyama, Aki; Otoguro, Kazuhiko; Ōmura, Satoshi. Solid-phase synthesis and biological activity of malformin C and its derivatives. J. Antibiot. 62(12), 681–686 (2009).

• 438 Inokoshi, Junji; Takagi, Yoichi; Uchida, Ryuji; Masuma, Rokuro; Ōmura, Satoshi; Tomoda, Hiroshi. Production of a new type of amidepsine with a sugar moiety by static fermentation of Humicola sp. FO-2942. J. Antibiot. 63(1), 9–16 (2010).

• 439 Shiomi, Kazuro; Matsui, Ryosuke; Kakei, Atsuo; Yamaguchi, Yuichi; Masuma, Rokuro; Hatano, Hiroko; Arai, Noriko; Isozaki, Miki; Tanaka, Haruo; Kobayashi, Susumu; Turberg, Andreas; Ōmura, Satoshi. Verticilide, a new ryanodine-binding inhibitor, produced by Verticillium sp. FKI-1033. J. Antibiot. 63(2), 77–82 (2010).

• 440 Uchida, Ryuji; Iwatsuki, Masato; Kim, Yong-Pil; Ohte, Satoshi; Ōmura, Satoshi; Tomoda, Hiroshi. Nosokomycins, new antibiotics discovered in an in vivo -mimic infection model using silkworm larvae. I: Fermentation, isolation and biological properties. J. Antibiot. 63(4), 151–155 (2010).

• 441 Uchida, Ryuji; Iwatsuki, Masato; Kim, Yong-Pil; Ōmura, Satoshi; Tomoda, Hiroshi. Nosokomycins, new antibiotics discovered in an in vivo -mimic infection model using silkworm larvae. II. Structure elucidation. J. Antibiot. 63(4), 157–163 (2010).

• 442 Koyama, Nobuhiro; Kojima, Shigenobu; Nonaka, Kenichi; Masuma, Rokuro; Matsumoto, Makoto; Ōmura, Satoshi; Tomoda, Hiroshi. Calpinactam, a new anti-mycobacterial agent, produced by Mortierella alpina FKI-4905. J. Antibiot. 63(4), 183–186 (2010).

• 443 Otoguro, Kazuhiko; Iwatsuki, Masato; Ishiyama, Aki; Namatame, Miyuki; Nishihara-Tsukashima, Aki; Sato, Seigo; Hatsu, Masahiro; Iinuma, Hironobu; Shibahara, Seiji; Nimura, Satoshi; Kondo, Shinichi; Yamada, Haruki; Ōmura, Satoshi. In vitro and in vivo antiprotozoal activities of bispolides and their derivatives. J. Antibiot. 63(5), 275–277 (2010).

• 444 Yamazaki, Hiroyuki; Ōmura, Satoshi; Tomoda, Hiroshi. Xanthoradone C, a new potentiator of imipenem activity against methicillin-resistant Staphylococcusaureus, produced by Penicillium radicum FKI-3765-2. J. Antibiot. 63(6), 329–330 (2010).

• 445 Iwatsuki, Masato; Kinoshita, Yuta; Niitsuma, Megumi; Hashida, Junko; Mori, Mihoko; Ishiyama, Aki; Namatame, Miyuki; Nishihara-Tsukashima, Aki; Nonaka, Kenichi; Masuma, Rokuro; Otoguro, Kazuhiko; Yamada, Haruki; Shiomi, Kazuro; Ōmura, Satoshi. Antitrypanosomal peptaibiotics, trichosporins B-VIIa and B-VIIb, produced by Trichoderma polysporum FKI-4452. J. Antibiot. 63(6), 331–333 (2010).

• 446 Otoguro, Kazuhiko; Iwatsuki, Masato; Ishiyama, Aki; Namatame, Miyuki; Nishihara-Tukashima, Aki; Shibahara, Seiji; Kondo, Shinichi; Yamada, Haruki; Ōmura, Satoshi. Promising lead compounds for novel antiprotozoals. J. Antibiot. 63(7), 381–384 (2010).

• 447 Ikeda, Shinsuke; Hanaki, Hideaki; Yanagisawa, Chie; Ikeda-Dantsuji, Yurika; Matsui, Hidehito; Iwatsuki, Masato; Shiomi, Kazuro; Nakae, Taiji; Sunakawa, Keisuke; Ōmura, Satoshi. Identification of the active component that induces vancomycin resistance in MRSA. J. Antibiot. 63(9), 533–538 (2010).

• 448 Hashida, Junko; Niitsuma, Megumi; Iwatsuki, Masato; Mori, Mihoko; Ishiyama, Aki; Namatame, Miyuki; Nishihara-Tsukashima, Aki; Nonaka, Kenichi; Ui, Hideaki; Masuma, Rokuro; Otoguro, Kazuhiko; Yamada, Haruki; Shiomi, Kazuro; Ōmura, Satoshi. Pyrenocine I, a new pyrenocine analog produced by Paecilomyces sp. FKI-3573. J. Antibiot. 63(9), 559–561 (2010).

• 449 Otoguro, Kazuhiko; Ishiyama, Aki; Iwatsuki, Masato; Namatame, Miyuki; Nishihara-Tukashima, Aki; Nakashima, Takuji; Shibahara, Seiji; Kondo, Shinichi; Yamada, Haruki; Ōmura, Satoshi. In vitro and in vivo anti- Trypanosoma brucei activities of phenazinomycin and related compounds. J. Antibiot. 63(9), 579–581 (2010).

• 450 Iwatsuki, Masato; Otoguro, Kazuhiko; Ishiyama, Aki; Namatame, Miyuki; Nishihara-Tukashima, Aki; Hashida, Junko; Nakashima, Takuji; Masuma, Rokuro; Takahashi, Yoko; Yamada, Haruki; Ōmura, Satoshi. In vitro antitrypanosomal activity of 12 low-molecular-weight antibiotics and observations of structure/activity relationships. J. Antibiot. 63(10), 619–622 (2010).

• 451 Takahashi, Atsushi; Inokoshi, Junji; Tsunoda, Masaru; Suzuki, Kaoru; Takenaka, Akio; Sekiguchi, Takeshi; Ōmura, Satoshi; Tanaka, Haruo. Actinohivin: specific amino acid residues essential for anti-HIV activity. J. Antibiot. 63(11), 661–665 (2010).

• 452 Niitsuma, Megumi; Hashida, Junko; Iwatsuki, Masato; Mori, Mihoko; Ishiyama, Aki; Namatame, Miyuki; Nishihara-Tsukashima, Aki; Matsumoto, Atsuko; Takahashi, Yoko; Yamada, Haruki; Otoguro, Kazuhiko; Shiomi, Kazuro; Ōmura, Satoshi. Sinefungin VA and dehydrosinefungin V, new antitrypanosomal antibiotics produced by Streptomyces sp. K05-0178. J. Antibiot. 63(11), 673–679 (2010).

• 453 Iwatsuki, Masato; Takada, Shohei; Mori, Mihoko; Ishiyama, Aki; Namatame, Miyuki; Nishihara-Tsukashima, Aki; Nonaka, Kenichi; Masuma, Rokuro; Otoguro, Kazuhiko; Shiomi, Kazuro; Ōmura, Satoshi. In vitro and in vivo antimalarial activity of puberulic acid and its new analogs, viticolins A-C, produced by Penicillium sp. FKI-4410. J. Antibiot. 64(2), 183–188 (2011).

• 454 Kimura, Kyota; Iwatsuki, Masato; Nagai, Takeshi; Matsumoto, Atsuko; Takahashi, Yoko; Shiomi, Kazuro; Ōmura, Satoshi; Abe, Akio. A small-molecule inhibitor of the bacterial type III secretion system protects against in vivo infection with Citrobacter rodentium. J. Antibiot. 64(2), 197–203 (2011).

• 455 Inahashi, Yuki; Matsumoto, Atsuko; Ōmura, Satoshi; Takahashi, Yoko. Streptosporangium oxazolinicum sp. nov., a novel endophytic actinomycete producing new antitrypanosomal antibiotics, spoxazomicins. J. Antibiot. 64(4), 297–302 (2011).

• 456 Inahashi, Yuki; Iwatsuki, Masato; Ishiyama, Aki; Namatame, Miyuki; Nishihara-Tsukashima, Aki; Matsumoto, Atsuko; Hirose, Tomoyasu; Sunazuka, Toshiaki; Yamada, Haruki; Otoguro, Kazuhiko; Takahashi, Yoko; Ōmura, Satoshi; Shiomi, Kazuro. Spoxazomicins A-C, novel antitrypanosomal alkaloids produced by an endophytic actinomycete, Streptosporangium oxazolinicum K07-0460^T. J. Antibiot. 64(4), 303–307 (2011).

• 457 Ishiyama, Aki; Iwatsuki, Masato; Namatame, Miyuki; Nishihara-Tsukashima, Aki; Sunazuka, Toshiaki; Takahashi, Yoko; Ōmura, Satoshi; Otoguro, Kazuhiko. Borrelidin, a potent antimalarial: stage-specific inhibition profile of synchronized cultures of Plasmodium falciparum. J. Antibiot. 64(5), 381–384 (2011).

• 458 Ohte, Satoshi; Matsuda, Daisuke; Uchida, Ryuji; Nonaka, Kenichi; Masuma, Rokuro; Ōmura, Satoshi; Tomoda, Hiroshi. Dinapinones, novel inhibitors of triacylglycerol synthesis in mammalian cells, produced by Penicillium pinophilum FKI-3864. J. Antibiot. 64(7), 489–494 (2011).

• 459 Takahashi, Atsushi; Inokoshi, Junji; Hachiya, Atsuko; Oka, Shinichi; Ōmura, Satoshi; Tanaka, Haruo. The high mannose-type glycan binding lectin actinohivin: dimerization greatly improves anti-HIV activity. J. Antibiot. 64(8), 551–557 (2011).

• 460 Nonaka, Kenichi; Abe, Tadahide; Iwatsuki, Masato; Mori, Mihoko; Yamamoto, Tsuyoshi; Shiomi, Kazuro; Ōmura, Satoshi; Masuma, Rokuro. Enhancement of metabolites productivity of Penicillium pinophilum FKI-5653, by co-culture with Trichoderma harzianum FKI-5655. J. Antibiot. 64(12), 769–774 (2011).

• 461 Ugaki, Narihiro; Matsuda, Daisuke; Yamazaki, Hiroyuki; Nonaka, Kenichi; Masuma, Rokuro; Ōmura, Satoshi; Tomoda, Hiroshi. New isochaetochromin, an inhibitor of triacylglycerol synthesis in mammalian cells, produced by Penicillium sp. FKI-4942: I. Taxonomy, fermentation, isolation and biological properties. J. Antibiot. 65(1), 15–19 (2012).

• 462 Ishiyama, Aki; Otoguro, Kazuhiko; Iwatsuki, Masato; Namatame, Miyuki; Nishihara-Tsukashima, Aki; Takahashi, Yoko; Onodera, Hideyuki; Yamada, Haruki; Ōmura, Satoshi. In vitro antitrypanosomal activity of five low-MW antibiotics. J. Antibiot. 65(2), 113–114 (2012).

• 463 Ishii, Takahiro; Nonaka, Kenichi; Iwatsuki, Masato; Masuma, Rokuro; Ōmura, Satoshi; Shiomi, Kazuro. Virgaricin produced by Virgaria sp. FKI-4860. J. Antibiot. 65(3), 139–141 (2012).

• 464 Iwatsuki, Masato; Nishihara-Tsukashima, Aki; Ishiyama, Aki; Namatame, Miyuki; Watanabe, Yoshio; Handasah, Siti; Pranamuda, Hardaning; Marwoto, Bambang; Matsumoto, Atsuko; Takahashi, Yoko; Otoguro, Kazuhiko; Ōmura, Satoshi. Jogyamycin, a new antiprotozoal aminocyclopentitol antibiotic, produced by Streptomyces sp. a-WM-JG-16.2. J. Antibiot. 65(3), 169–171 (2012).

• 465 Hashida, Junko; Niitsuma, Megumi; Iwatsuki, Masato; Mori, Mihoko; Ishiyama, Aki; Namatame, Miyuki; Nishihara-Tsukashima, Aki; Matsumoto, Atsuko; Ara, Ismet; Takahashi, Yoko; Yamada, Haruki; Otoguro, Kazuhiko; Shiomi, Kazuro; Ōmura, Satoshi. Panowamycins A and B, new antitrypanosomal isochromans produced by Streptomyces sp. K07-0010. J. Antibiot. 65(4), 197–202 (2012).

• 466 Koyama, Ryo; Matsumoto, Atsuko; Inahashi, Yuki; Ōmura, Satoshi; Takahashi, Yoko. Isolation of actinomycetes from the root of the plant, Ophiopogon japonicus, and proposal of two new species, Actinoallomurus liliacearum sp. nov. and Actinoallomurus vinaceus sp. nov. J. Antibiot. 65(7), 335–340 (2012).

• 467 Sugawara, Akihiro; Sueki, Akito; Hirose, Tomoyasu; Shima, Hideaki; Akagawa, Kiyoko S.; Ōmura, Satoshi; Sunazuka, Toshiaki. Novel 12-membered non-antibiotic macrolides, EM900 series with anti-inflammatory and/or immunomodulatory activity; synthesis, structure-activity relationships and in vivo study. J. Antibiot. 65(9), 487–490 (2012).

• 468 Suga, Takuya; Ishii, Takahiro; Iwatsuki, Masato; Yamamoto, Tsuyoshi; Nonaka, Kenichi; Masuma, Rokuro; Matsui, Hidehito; Hanaki, Hideaki; Ōmura, Satoshi; Shiomi, Kazuro. Aranorosin circumvents arbekacin-resistance in MRSA by inhibiting the bifunctional enzyme AAC (6')/APH (2''). J. Antibiot. 65(10), 527–529 (2012).

• 469 Tsutsui, Ayumi; Hirose, Tomoyasu; Ishiyama, Aki; Iwatsuki, Masato; Yokota, Arisa; Maruyama, Hitomi; Matsui, Hidehito; Otoguro, Kazuhiko; Hanaki, Hideaki; Ōmura, Satoshi; Sunazuka, Toshiaki. Antimalarial C-9 oxime derivatives from desmycosin, produced by click chemistry. J. Antibiot. 66(3), 191–194 (2013).

• 470 Nakashima, Takuji; Okuyama, Ryuki; Kamiya, Yoshiyuki; Matsumoto, Atsuko; Iwatsuki, Masato; Inahashi, Yuki; Yamaji, Kenzaburo; Takahashi, Yoko; Ōmura, Satoshi. Trehangelins A, B and C, novel photo-oxidative hemolysis inhibitors produced by an endophytic actinomycete, Polymorphospora rubra K07-0510. J. Antibiot. 66(6), 311–317 (2013).

• 471 Umeyama, Akemi; Takahashi, Koichi; Grudniewska, Aleksandra; Shimizu, Mina; Hayashi, Sayaka; Kato, Masayuki; Okamoto, Yasuko; Suenaga, Midori; Ban, Sayaka; Kumada, Toshio; Ishiyama, Aki; Iwatsuki, Masato; Otoguro, Kazuhiko; Ōmura, Satoshi; Hashimoto, Toshihiro. In vitro antitrypanosomal activity of the cyclodepsipeptides, cardinalisamides A-C, from the insect pathogenic fungus Cordyceps cardinalis NBRC 103832. J. Antibiot. 67(2), 163–166 (2014).

• 472 Sugamata, Ryuichi; Sugawara, Akihiro; Nagao, Tomokazu; Suzuki, Koya; Hirose, Tomoyasu; Yamamoto, Ki-ichi; Oshima, Masamichi; Kobayashi, Kazuo; Sunazuka, Toshiaki; Akagawa, Kiyoko S.; Ōmura, Satoshi; Nakayama, Toshinori; Suzuki, Kazuo. Leucomycin A₃, a 16-membered macrolide antibiotic, inhibits influenza A virus infection and disease progression. J. Antibiot. 67(3), 213–222 (2014).

• 473 Nakashima, Takuji; Iwatsuki, Masato; Ochiai, Junya; Kamiya, Yoshiyuki; Nagai, Kenichiro; Matsumoto, Atsuko; Ishiyama, Aki; Otoguro, Kazuhiko; Shiomi, Kazuro; Takahashi, Yoko; Ōmura, Satoshi. Mangromicins A and B. structure and antitrypanosomal activity of two new cyclopentadecane compounds from Lechevalieria aerocolonigenes K10-0216. J. Antibiot. 67(3), 253–260 (2014).

• 474 Nakashima, Takuji; Kamiya, Yoshiyuki; Iwatsuki, Masato; Takahashi, Yoko; Ōmura, Satoshi. Mangromicins, six new antioxidative agents isolated from a culture broth of the actinomycete, Lechevalieria aerocolonigenes K10-0216. J. Antibiot. 67(7), 533–539 (2014).

• 475 Ishiyama, Aki; Iwatsuki, Masato; Yamamoto, Tsuyoshi; Miura, Hiromi; Ōmura, Satoshi; Otoguro, Kazuhiko. Antimalarial tropones and their Plasmodium falciparum glyoxalase I (pfGLOI) inhibitory activity. J. Antibiot. 67(7), 545–547 (2014).

• 476 Nonaka, Kenichi; Todaka, Nemuri; Ōmura, Satoshi; Masuma, Rokuro. Combination cellulose plate (non-agar solid support) and agar plate method improves isolation of fungi from soil. J. Antibiot. 67(11), 755–761 (2014).

• 477 Nakashima, Takuji; Kamiya, Yoshiyuki; Iwatsuki, Masato; Sato, Noriko; Takahashi, Yoko; Ōmura, Satoshi. Mangromicin C, a new analog of mangromicin. J. Antibiot. 68(3), 220–222 (2015).

• 478 Take, Akira; Matsumoto, Atsuko; Ōmura, Satoshi; Takahashi, Yoko. Streptomyces lactacystinicus sp. nov. and Streptomyces cyslabdanicus sp. nov., producing lactacystin and cyslabdan, respectively. J. Antibiot. 68(5), 322–327 (2015).

• 479 Nakashima, Takuji; Kamiya, Yoshiyuki; Yamaji, Kenzaburo; Iwatsuki, Masato; Sato, Noriko; Takahashi, Yoko; Ōmura, Satoshi. New steroidal compounds from an actinomycete strain, Lechevalieria aerocolonigenes K10-0216. J. Antibiot. 68(5), 348–350 (2015).

• 480 Kaifuchi, Satoru; Mori, Mihoko; Nonaka, Kenichi; Masuma, Rokuro; Ōmura, Satoshi; Shiomi, Kazuro. Sartorypyrone D: a new NADH-fumarate reductase inhibitor produced by Neosartorya fischeri FO-5897. J. Antibiot. 68(6), 403–405 (2015).

• 481 Ishiyama, Aki; Iwatsuki, Masato; Hokari, Rei; Sawa, Masaaki; Ōmura, Satoshi; Otoguro, Kazuhiko. Antimalarial activity of kinase inhibitor, nilotinib, in vitro and in vivo. J. Antibiot. 68(7), 469–472 (2015).

• 482 Nonaka, Kenichi; Chiba, Takuya; Suga, Takuya; Asami, Yukihiro; Iwatsuki, Masato; Masuma, Rokuro; Ōmura, Satoshi; Shiomi, Kazuro. Coculnol, a new penicillic acid produced by a coculture of Fusarium solani FKI–6853 and Talaromyces sp. FKA-65. J. Antibiot. 68(8), 530–532 (2015).

• 483 Nonaka, Kenichi; Iwatsuki, Masato; Horiuchi, Syunsuke; Shiomi, Kazuro; Ōmura, Satoshi; Masuma, Rokuro. Induced production of BE-31405 by co-culturing of Talaromyces siamensis FKA-61 with a variety of fungal strains. J. Antibiot. 68(9), 573–578 (2015).

• 484 Ishii, Takahiro; Nonaka, Kenichi; Sugawara, Akihiro; Iwatsuki, Masato; Masuma, Rokuro; Hirose, Tomoyasu; Sunazuka, Toshiaki; Ōmura, Satoshi; Shiomi, Kazuro. Cinatrins D and E, and virgaricin B, three novel compounds produced by a fungus, Virgaria boninensis FKI-4958. J. Antibiot. 68(10), 633–637 (2015).

• 485 Suga, Takuya; Asami, Yukihiro; Hashimoto, Shohei; Nonaka, Kenichi; Iwatsuki, Masato; Nakashima, Takuji; Sugahara, Ryohei; Shiotsuki, Takahiro; Yamamoto, Takenori; Shinohara, Yasuo; Ichimaru, Naoya; Murai, Masatoshi; Miyoshi, Hideto; Ōmura, Satoshi; Shiomi, Kazuro. Ascosteroside C, a new mitochondrial respiration inhibitor discovered by pesticidal screening using recombinant Saccharomyces cerevisiae. J. Antibiot. 68(10), 649–652 (2015).

• 486 Seki, Tamae; Matsumoto, Atsuko; Ōmura, Satoshi; Takahashi, Yoko. Distribution and isolation of strains belonging to the order Solirubrobacterales. J. Antibiot. 68(12), 763–766 (2015).

• 487 Sugawara, Akihiro; Shima, Hideaki; Sueki, Akito; Hirose, Tomoyasu; Matsui, Hidehito; Nakano, Hayato; Hanaki, Hideaki; Akagawa, Kiyoko S.; Ōmura, Satoshi; Sunazuka, Toshiaki. Non-antibiotic 12-membered macrolides: design, synthesis and biological evaluation in a cigarette-smoking model. J. Antibiot. 69(4), 319–326 (2016).

• 488 Suga, Takuya; Shiina, Mayu; Asami, Yukihiro; Iwatsuki, Masato; Yamamoto, Tsuyoshi; Nonaka, Kenichi; Masuma, Rokuro; Matsui, Hidehito; Hanaki, Hideaki; Iwamoto, Susumu; Onodera, Hideyuki; Kazuro, hiomi; Ōmura, Satoshi. Paraphaeosphaeride D and berkleasmin F, new circumventors of arbekacin resistance in MRSA, produced by Paraphaeosphaeria sp. TR-022. J. Antibiot. 69(8), 605–610 (2016).

• 489 Nakashima, Takuji; Miyano, Rei; Iwatsuki, Masato; Shirahata, Tatsuya; Kimura, Toru; Asami, Yukihiro; Kobayashi, Yoshinori; Shiomi, Kazuro; Petersson, George A.; Takahashi, Yoko; Ōmura, Satoshi. Iminimycin A, the new iminium metabolite produced by Streptomyces griseus OS-3601. J. Antibiot. 69(8), 611–615 (2016).

• 490 Shiina, Mayu; Suga, Takuya; Asami, Yukihiro; Nonaka, Kenichi; Iwatsuki, Masato; Ōmura, Satoshi; Shiomi, Kazuro. Euvesperins A and B, new circumventors of arbekacin resistance in MRSA, produced by Metarhizium sp. FKI-7236. J. Antibiot. 69(9), 719–722 (2016).

• 491 Kimura, Toru; Iwatsuki, Masato; Asami, Yukihiro; Ishiyama, Aki; Hokari, Rei; Otoguro, Kazuhiko; Matsumoto, Atsuko; Sato, Noriko; Shiomi, Kazuro; Takahashi, Yoko; Ōmura, Satoshi; Nakashima, Takuji. Anti-trypanosomal compound, sagamilactam, a new polyene macrocyclic lactam from Actinomadura sp. K13-0306. J. Antibiot. 69(11), 818–824 (2016).

• 492 Horikoshi, Ryo; Goto, Kimihiko; Mitomi, Masaaki; Oyama, Kazuhiko; Sunazuka, Toshiaki; Ōmura, Satoshi. Identification of pyripyropene A as a promising insecticidal compound in a microbial metabolite screening. J. Antibiot. 70(3), 272–276 (2017).

• 493 Watanabe, Yoshihiro; Suga, Takuya; Narusawa, Satomi; Iwatsuki, Masato; Nonaka, Kenichi; Nakashima, Takuji; Shinohara, Yasuo; Shiotsuki, Takahiro; Ichimaru, Naoya; Miyoshi, Hideto; Asami, Yukihiro; Ōmura, Satoshi; Shiomi, Kazuro. Decatamariic acid, a new mitochondrial respiration inhibitor discovered by pesticidal screening using drug-sensitive Saccharomyces cerevisiae. J. Antibiot. 70(4), 395–399 (2017).

• 494 Fukumoto, Atsushi; Kim, Yong-Pil; Matsumoto, Atsuko; Takahashi, Yoko; Suzuki, Makoto; Onodera, Hideyuki; Tomoda, Hiroshi; Matsui, Hidehito; Hanaki, Hideaki; Iwatsuki, Masato; Ōmura, Satoshi; Shiomi, Kazuro. Naphthacemycins, novel circumventors of β-lactam resistance in MRSA, produced by Streptomyces sp. KB-3346-5. I. The taxonomy of the producing strain, and the fermentation, isolation and antibacterial activities. J. Antibiot. (in press).

• 495 Fukumoto, Atsushi; Kim, Yong-Pil; Iwatsuki, Masato; Hirose, Tomoyasu; Sunazuka, Toshiaki; Hanaki, Hideaki; Ōmura, Satoshi; Shiomi, Kazuro. Naphthacemycins, novel circumventors of β-lactam resistance in MRSA, produced by Streptomyces sp. KB-3346-5. II. Structure elucidation. J. Antibiot. (in press).

• 496 Hirose, Tomoyasu; Kojima, Yasuhiro; Matsui, Hidehito; Hanaki, Hideaki; Iwatsuki, Masato; Shiomi, Kazuro; Ōmura, Satoshi; Sunazuka, Toshiaki. Total synthesis of (±)-naphthacemycin A₉, possessing both antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and circumventing effect of β-lactam resistance. J. Antibiot. (in press).

• 497 Ohtawa, Masaki; Arima, Shiho; Shimizu, Risa; Hanatani, Naomi; Shimizu, Eri; Shiomi, Kazuro; Kita, Kiyoshi; Ōmura, Satoshi; Nagamitsu, Tohru. Development of a new air-stable structure-simplified nafuredin-γ analog as a potent and selective nematode complex I inhibitor. J. Antibiot. (in press).

• 498 Katz, Naftale; Araújo, Neusa; Coelho, Paulo Marcos Zech; Morel, Carlos Medicis; Linde-Arias, Ana Rosa; Yamada, Takeshi; Horimatsu, Yuki; Suzuki, Koh; Sunazuka, Toshiaki; Ōmura Satoshi. Ivermectin efficacy against Biomphalaria, intermediate host snail vectors of Schistosomiasis. J. Antibiot. (in press).

• 499 Shirahata, Tatsuya; Ino, Chieko; Mizuno, Fumi; Asada, Yoshihisa; Hirotani, Masao; Petersson, George A.; Ōmura, Satoshi; Yoshikawa, Takafumi; Kobayashi, Yoshinori. γ -Ionylidene-type sesquiterpenoids possessing antimicrobial activity against Porphyromonas gingivalis, from Phellinus linteus and their absolute structure determination. J. Antibiot. (in press).