Original Article

The Journal of Antibiotics (2016) 69, 331–336; doi:10.1038/ja.2016.25; published online 9 March 2016

Synthetic studies toward citrinadin A: construction of the pentacyclic core

Monica E McCallum1, Genessa M Smith1, Takanori Matsumaru1, Ke Kong1, John A Enquist Jr1 and John L Wood1

1Department of Chemistry and Biochemistry, Baylor University, Waco, TX, USA

Correspondence: Professor John L Wood, Department of Chemsitry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798, USA. E-mail: John_L_Wood@baylor.edu

Received 20 December 2015; Revised 13 January 2016; Accepted 16 January 2016
Advance online publication 9 March 2016

This manuscript is dedicated to Professor Amos B. Smith, III, an inspirational mentor and good friend.



This manuscript describes the preparation of an advanced intermediate toward the total synthesis of citrinadin A, featuring a [3+2] cycloaddition employing in situ generation of the dipole.

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