Original Article

The Journal of Antibiotics (2016) 69, 331–336; doi:10.1038/ja.2016.25; published online 9 March 2016

Synthetic studies toward citrinadin A: construction of the pentacyclic core

Monica E McCallum1, Genessa M Smith1, Takanori Matsumaru1, Ke Kong1, John A Enquist Jr1 and John L Wood1

1Department of Chemistry and Biochemistry, Baylor University, Waco, TX, USA

Correspondence: Professor John L Wood, Department of Chemsitry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798, USA. E-mail: John_L_Wood@baylor.edu

Received 20 December 2015; Revised 13 January 2016; Accepted 16 January 2016
Advance online publication 9 March 2016

This manuscript is dedicated to Professor Amos B. Smith, III, an inspirational mentor and good friend.

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Abstract

This manuscript describes the preparation of an advanced intermediate toward the total synthesis of citrinadin A, featuring a [3+2] cycloaddition employing in situ generation of the dipole.

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