In vitro evaluation of the antimicrobial activity of HM-242, a novel antiseptic compound

doi:doi:10.1038/ja.2009.56

The Journal of Antibiotics (2009) 62, 489–493; doi:10.1038/ja.2009.56; published online 3 July 2009

In vitro evaluation of the antimicrobial activity of HM-242, a novel antiseptic compound

Junji Okunishi¹, Yutaka Nishihara¹, Shirou Maeda² and Masahiro Ikeda¹

¹Department of Preclinical Development, Central Research Laboratories, Maruishi Pharmaceutical Co. Ltd, Osaka, Japan
²CT Laboratory, Hamari Chemicals Ltd, Osaka, Japan

Correspondence: J Okunishi, Central Research Laboratories, Maruishi Pharmaceutical Co. Ltd, 2-2-18, Imazu-Naka, Tsurumi-Ku, Osaka 538-0042, Japan. E-mail: junji_okunishi@maruishi-pharm.co.jp

Received 8 May 2009; Revised 29 May 2009; Accepted 5 June 2009; Published online 3 July 2009.

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Abstract

The antimicrobial activities of N⁴-octyl-6,6-dimethyl-N²-(4-methylbenzyl)-1,6-dihydro-1,3,5-triazine-2,4-diamine (HM-242), a novel synthetic compound, were compared with those of chlorhexidine gluconate (CHG). HM-242 was a more potent microbicide than CHG in vitro; however, its minimal inhibitory concentrations were similar. In particular, HM-242 killed various Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis, both efficiently and rapidly. HM-242 also showed potent virucidal activity against enveloped viruses such as influenza virus and herpes simplex virus. These characteristics suggest that HM-242 may well be useful as an antiseptic.