Original Article

The Journal of Antibiotics (2008) 61, 7–10; doi:10.1038/ja.2008.102

Cyslabdan, a New Potentiator of Imipenem Activity against Methicillin-resistant Staphylococcus aureus, Produced by Streptomyces sp. K04-0144

II. Biological Activities

Atsushi Fukumoto1, Yong-Pil Kim2, Hideaki Hanaki2, Kazuro Shiomi1, Hiroshi Tomoda2,3 and Satoshi Ōmura1,2

  1. 1Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan
  2. 2The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8642, Japan
  3. 3School of Pharmacy, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan

Correspondence: S. Ōmura, Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan. E-mail: omura-s@kitasato.or.jp; H. Tomoda, School of Pharmacy, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan. E-mail: tomodah@pharm.kitasato-u.ac.jp

Received 5 October 2007; Accepted 4 December 2007.

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Abstract

Cyslabdan produced by Streptomyces sp. K04-0144 was found to potentiate imipenem activity against methicillin-resistant Staphylococcus aureus (MRSA). The MIC value of imipenem against MRSA was reduced from 16 to 0.015 mug/ml in combination with cyslabdan. Study on anti-MRSA activity of other typical antibiotics in combination with cyslabdan showed that the potentiating activity was limited to beta-lactam antibiotics. Furthermore, among beta-lactam antibiotics, the activity of carbapenems was most remarkably poteintiated by cyslabdan.

Keywords:

cyslabdan, imipenem potentiator, methicillin-resistant Staphylococcus aureus, MRSA, Streptomyces sp. K04-0144, beta-lactam

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References

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