Original Article

The Journal of Antibiotics (2007) 60, 301–308; doi:10.1038/ja.2007.38

New Aromatic Nitro Compounds from Salegentibacter sp. T436, an Arctic Sea Ice Bacterium: Taxonomy, Fermentation, Isolation and Biological Activities

Wael Al-Zereini1, Imelda Schuhmann2, Hartmut Laatsch2, Elisabeth Helmke3 and Heidrun Anke1

  1. 1Institute for Biotechnology and Drug Research (IBWF), Erwin-Schrödinger-Strasse 56, D-67663 Kaiserslautern, Germany
  2. 2Institute of Organic and Biomolecular Chemistry, University of Göttingen, Tammannstrasse 2, D-37077 Göttingen, Germany
  3. 3Alfred-Wegener-Institute for Polar and Marine Research, Am Handelshafen 12, 27570 Bremerhaven, Germany

Correspondence: H. Anke, Institute for Biotechnology and Drug Research (IBWF), Erwin-Schrödinger-Strasse 56, D-67663 Kaiserslautern, Germany. E-mail: anke@ibwf.de

Received 2 February 2007; Accepted 9 April 2007.

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Abstract

Nineteen aromatic nitro compounds were isolated from the culture broth of an Artic sea ice bacterium. Four of these compounds are new and six compounds are reported from a natural source for the first time. The new natural products showed weak antimicrobial and cytotoxic activities. 2-Nitro-4-(2'-nitroethenyl)-phenol was the most potent antimicrobial and cytotoxic substance. Some of the compounds exhibit plant growth modulating activities. Based on its biochemical properties and the 16S rRNA gene sequence, the producing strain can be described as a distinct species within the genus Salegentibacter.

Keywords:

marine bacteria, aromatic nitro compounds, antibacterial activity, cytotoxic activity, Salegentibacter

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