Original Article

The Journal of Antibiotics (2006) 59, 53–56; doi:10.1038/ja.2006.8

The Dasyscyphins A~C and Niveulone, New Biologically Active Compounds from the Ascomycete Dasyscyphus niveus

Viktor Mierau1, Veronica Rojas de La Parra2, Olov Sterner2 and Timm Anke1

  1. 1Institute of Biotechnology and Drug Research (IBWF), Erwin-Schrödinger-Str. 56, D-67663 Kaiserslautern, Germany
  2. 2Department of Organic and Bioorganic Chemistry, University of Lund P.O.Box 124, S-22100 Lund, Sweden

Correspondence: T. Anke, Institute of Biotechnology and Drug Research (IBWF), Erwin-Schrödinger-Str. 56, D-67663 Kaiserslautern, Germany. E-mail: anke@rhrk.uni-kl.de

Received 21 September 2005; Accepted 27 December 2005.



In the course of a screening for cytotoxic compounds from fungi four new terpenoid metabolites, named dasyscyphins A, B, C, and niveulone were isolated from fermentations of Dasyscyphus niveus strain A0101. While dasyscyphin A (1) exhibited no significant biological activities in our test systems dasyscyphin B (2) and dasyscyphin C (3) showed cytotoxic activities against human (HepG2, Hela S3, U937, Colo-320, Jurkat) cell lines with IC50-values of 0.5~3 microg/ml while the activity of niveulone (4) was less pronounced. Only modest or weak antibiotic properties were observed for (2) and (3).


dasyscyphins A~C, niveulone, Dasyscyphus niveus, cytotoxic activities



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