Abstract
A phenalenone compound, atrovenetinone methyl acetal, was isolated from a culture broth of Penicillium sp. FKI-1463 as an HIV-1 integrase inhibitor, and it showed anti-HIV activity in vitro. HIV-1 integrase inhibition and anti-HIV activity of two other natural phenalenones were also studied. Among the tested compounds, funalenone inhibited HIV-1 integrase with an IC50 value of 10 µM and showed the best selectivity (anti-HIV, IC50=1.7 µM; cytotoxicity, IC50=87 µM).
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Shiomi, K., Matsui, R., Isozaki, M. et al. Fungal Phenalenones Inhibit HIV-1 Integrase. J Antibiot 58, 65–68 (2005). https://doi.org/10.1038/ja.2005.8
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DOI: https://doi.org/10.1038/ja.2005.8
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