The ISME Journal

FIGURE 6

FROM:

A metabolomic view of how the human gut microbiota impacts the host metabolome using humanized and gnotobiotic mice

A Marcobal, P C Kashyap, T A Nelson, P A Aronov, M S Donia, A Spormann, M A Fischbach and J L Sonnenburg

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Figure 6.

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Gut microbial diversity and human fecal metabolome are reconstituted in HUM mice. (a) Principal co-ordinate analysis (PCOA) plot of 16S rRNA-based gut microbial profiling from HUM mice from three different donors (n=4–8 mice per group) and the respective donor samples (open enlarged symbols). (b) Percent of features found in human feces, HUM mouse feces or both, for the three respective donor/recipient groups using RPLC-ESI+. (c) Venn diagram with metabolites common to the human and HUM mice samples for each donor/recipient group. (d) PCA plot of fecal metabolite profiling from HUM mice colonized with three different fecal samples.

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