The ISME Journal

FIGURE 1

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A metabolomic view of how the human gut microbiota impacts the host metabolome using humanized and gnotobiotic mice

A Marcobal, P C Kashyap, T A Nelson, P A Aronov, M S Donia, A Spormann, M A Fischbach and J L Sonnenburg

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Figure 1.

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Ultra performance liquid chromatography (UPLC)-MS analysis reveals microbial-related metabolites in fecal and urine samples of HUM mice. (a) Experimental workflow for metabolomic data generation and analysis. (b) Number of features detected in feces and urine of at least one of three HUM mice by different UPLC-MS methods. (c) Number of significantly different features (P<0.01, >10-fold difference) between HUM (n=3) and GF (n=3) mice found in urine or fecal metabolome. (d) Percentage of predicted isotopes and adducts in the set of features characteristic of feces from HUM mice (RPLC-ESI+).

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