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Nature Reviews Molecular Cell Biology 4, 497–502 (1 June 2003) | doi:10.1038/nrm1126
The present view of the mechanism of protein folding
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Abstract
We can track the positions and movements of all the atoms in small proteins as they fold and unfold by combining experimental studies with atomic-resolution molecular dynamics simulations. General principles as to how such complex architectures form so rapidly are now emerging from in-depth studies of a few proteins.
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