Advance online publication
The latest research papers, published online ahead of print. These online versions are definitive and may be cited using the digital object identifier (DOI).
About advance online publicationArticles
Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin
Shu-ichi Okamoto, Mahmoud A Pouladi, Maria Talantova, Dongdong Yao, Peng Xia, Dagmar E Ehrnhoefer, Rameez Zaidi, Arjay Clemente, Marcus Kaul, Rona K Graham, Dongxian Zhang, H-S Vincent Chen, Gary Tong, Michael R Hayden & Stuart A Lipton
Published online: 15 November 2009 | doi:10.1038/nm.2056
In a mouse model of Huntington's disease, synaptic activation of NMDA receptors induces the formation of huntingtin-containing inclusions, rendering neurons more resistant to death in vivo and in vitro. In contrast, stimulation of extrasynaptic NMDA receptors increases neuronal vulnerability by preventing inclusion formation.
Abstract - | Full Text - Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin | PDF (941 KB) - Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin | Supplementary information
Synovial fibroblasts spread rheumatoid arthritis to unaffected joints
Stephanie Lefèvre, Anette Knedla, Christoph Tennie, Andreas Kampmann, Christina Wunrau, Robert Dinser, Adelheid Korb, Eva-Maria Schnäker, Ingo H Tarner, Paul D Robbins, Christopher H Evans, Henning Stürz, Jürgen Steinmeyer, Steffen Gay, Jürgen Schölmerich, Thomas Pap, Ulf Müller-Ladner & Elena Neumann
Published online: 08 November 2009 | doi:10.1038/nm.2050
Rheumatoid arthritis usually begins in one joint but spreads to other joints as the disease progresses. Elena Neumann and her colleagues show that rheumatoid arthritis synovial fibroblasts (RASFs) may be key mediators of this process. They show, using a SCID mouse model, that human RASFs can migrate long distances through the bloodstream from diseased cartilage to unaffected cartilage, where they can mount a new attack.
Abstract - | Full Text - Synovial fibroblasts spread rheumatoid arthritis to unaffected joints | PDF (1,001 KB) - Synovial fibroblasts spread rheumatoid arthritis to unaffected joints | Supplementary information
Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotype
Daniel T Starczynowski, Florian Kuchenbauer, Bob Argiropoulos, Sandy Sung, Ryan Morin, Andrew Muranyi, Martin Hirst, Donna Hogge, Marco Marra, Richard A Wells, Rena Buckstein, Wan Lam, R Keith Humphries & Aly Karsan
Published online: 08 November 2009 | doi:10.1038/nm.2054
For myelodysplastic syndromes caused by deletion of chromosome 5q, Daniel Starczynowski et al. provide evidence that decreased expression of two miRNAs in this region—miR-145 and miR-146a—contributes to abnormal megakaryocyte differentiation and platelet production and progression of the disease to either bone marrow failure or leukemia. The authors also provide a mechanistic explanation for these effects by which loss of these two miRNAs leads to derepression of innate immune signaling.
Abstract - | Full Text - Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotype | PDF (1,288 KB) - Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotype | Supplementary information
Letter
Modulating hedgehog signaling can attenuate the severity of osteoarthritis
Alvin C Lin, Brian L Seeto, Justyna M Bartoszko, Michael A Khoury, Heather Whetstone, Louisa Ho, Claire Hsu, Amanda S Ali & Benjamin A Alman
Published online: 15 November 2009 | doi:10.1038/nm.2055
In a new report, Benjamin Alman and his colleagues find that the morphogenic pathway activated by Hedgehog signaling is a key mediator of osteoarthritis, a condition that is marked by irreversible degeneration of the joints and with no current treatment. They also found that blockade of Hedgehog signaling prevented osteoarthritis in a mouse model, suggesting this pathway as a possible target to treat this devastating disease.
Abstract - | Full Text - Modulating hedgehog signaling can attenuate the severity of osteoarthritis | PDF (1,028 KB) - Modulating hedgehog signaling can attenuate the severity of osteoarthritis | Supplementary information
Until print versions of AOP papers are published, they should be cited in the style "Author(s) Nature Medicine advance online publication, day month year (doi:10.1038/nmXXXXX)". Once the print version (identical to the AOP) is published, it should be cited as follows: "Author(s) Nature Medicine volume, page (year); advance online publication, (doi:10.1038/nmXXXXX)".
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